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Index > Protein center > GC(Gene name) > Human
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  • GC (Gene name),
  • Vitamin D-binding protein (Protein name ),  VTDB_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    GC;
    Protein name:
    Vitamin D-binding protein(DBP;VDB);
    Alternative:
    Group-specific component;Gc-globulin;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Function:
    Multifunctional protein found in plasma, ascitic fluid, cerebrospinal fluid, and urine and on the surface of many cell types. In plasma, it carries the vitamin D sterols and prevents polymerization of actin by binding its monomers. DBP associates with membrane-bound immunoglobulin on the surface of B-lymphocytes and with IgG Fc receptor on the membranes of T-lymphocytes.
    Subcellular Location:
    Secreted
    Protein Attributes:
    Sequence length:
    474
    Sequence:
    50:
    MKRVLVLLLA | VAFGHALERG | RDYEKNKVCK | EFSHLGKEDF | TSLSLVLYSR | 
    100:
    KFPSGTFEQV | SQLVKEVVSL | TEACCAEGAD | PDCYDTRTSA | LSAKSCESNS | 
    150:
    PFPVHPGTAE | CCTKEGLERK | LCMAALKHQP | QEFPTYVEPT | NDEICEAFRK | 
    200:
    DPKEYANQFM | WEYSTNYGQA | PLSLLVSYTK | SYLSMVGSCC | TSASPTVCFL | 
    250:
    KERLQLKHLS | LLTTLSNRVC | SQYAAYGEKK | SRLSNLIKLA | QKVPTADLED | 
    300:
    VLPLAEDITN | ILSKCCESAS | EDCMAKELPE | HTVKLCDNLS | TKNSKFEDCC | 
    350:
    QEKTAMDVFV | CTYFMPAAQL | PELPDVELPT | NKDVCDPGNT | KVMDKYTFEL | 
    400:
    SRRTHLPEVF | LSKVLEPTLK | SLGECCDVED | STTCFNAKGP | LLKKELSSFI | 
    450:
    DKGQELCADY | SENTFTEYKK | KLAERLKAKL | PDATPKELAK | LVNKRSDFAS | 
    474:
    NCCSINSPPL | YCDSEIDAEL | KNIL
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    MIM:
    String:
    KEGG:
    SMR:
    UniGene:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human DBP
    Cat.:
    E1810h
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    96T
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    ELISA Kit for Human DBP
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    E1810m
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    MSDS:
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    96T
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    ELISA Kit for Human DBP
    Cat.:
    E1810r
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    MSDS:
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    96T
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    ELISA Kit for Human DBP
    Cat.:
    E1810b
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    MSDS:
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    96T
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    ELISA Kit for Human DBP
    MSDS:
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    CLIA Kit for Human DBP
    Cat.:
    U1810b
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human DBP
    Cat.:
    U1810h
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human DBP
    Cat.:
    U1810m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human DBP
    Cat.:
    U1810r
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    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
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    CLIA Kit for Human DBP
    MSDS:
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    Polyclonal Antibody for Human DBP
    Polyclonal Antibody for Human DBP
    Polyclonal Antibody for Human DBP
    Cat.:
    P1810Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human DBP
    Cat.:
    P1810Rb-m
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human DBP
    Cat.:
    P1810Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human DBP
    Monoclonal Antibody for Human DBP
    Monoclonal Antibody for Human DBP
    Monoclonal Antibody for Human DBP
    Monoclonal Antibody for Human DBP
    Protein for Human DBP
    Protein for Human DBP
    Protein for Human DBP
    Protein for Human DBP
    Protein for Human DBP

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    References
    1. 1.
      "Serum vitamin D-binding protein is a third member of the albumin and alpha fetoprotein gene family."
      Cooke N.E. , David E.V.
      J. Clin. Invest.76:2420-2424(1985) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANTS GLU-432 AND THR-436
    2. 2.
      "Human group-specific component (Gc) is a member of the albumin family."
      Yang F. , Brune J.L. , Naylor S.L. , Cupples R.L. , Naberhaus K.H. , Bowman B.H.
      Proc. Natl. Acad. Sci. U.S.A.82:7994-7998(1985) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    3. 3.
      "Sequence and organization of the human vitamin D-binding protein gene."
      Braun A. , Kofler A. , Morawietz S. , Cleve H.
      Biochim. Biophys. Acta1216:385-394(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS GLU-432 AND THR-436
    4. 4.
      "Complete structure of the human Gc gene: differences and similarities between members of the albumin gene family."
      Witke W.F. , Gibbs P.E. , Zielinski R. , Yang F. , Bowman B.H. , Dugaiczyk A.
      Genomics16:751-754(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS GLU-432 AND THR-436
    5. 5.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-47 (ISOFORM 2);VARIANTS GLU-432; THR-436 AND HIS-445
      tissue: Liver.
    6. 6.
      Totoki Y. , Toyoda A. , Takeda T. , Sakaki Y. , Tanaka A. , Yokoyama S.
      Submitted (2005-04) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANTS GLU-432 AND THR-436
      tissue: Kidney.
    7. 7.
      "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W. , Graves T.A. , Fulton R.S. , Fulton L.A. , Pepin K.H. , Minx P. , Wagner-McPherson C. , Layman D. , Wylie K. , Sekhon M. , Becker M.C. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , Nash W.E. , Kremitzki C. , Oddy L. , Du H. , more...
      Nature434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA];VARIANTS THR-436 AND HIS-445
    8. 8.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA];VARIANTS GLU-432 AND THR-436
    9. 9.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT THR-436
      tissue: Liver.
    10. 10.
      "The vitamin D-binding protein gene contains conserved nucleotide sequences that respond to heavy metal, adipocyte and mitotic signals."
      Yang F. , Naberhaus K.H. , Adrian G.S. , Gardella J.M. , Brissenden J.E. , Bowman B.H.
      Gene54:285-290(1987) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-19
    11. 11.
      "Complete amino acid sequence of human vitamin D-binding protein (group-specific component): evidence of a three-fold internal homology as in serum albumin and alpha-fetoprotein."
      Schoentgen F. , Metz-Boutigue M.-H. , Jolles J. , Constans J. , Jolles P.
      Biochim. Biophys. Acta871:189-198(1986) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 17-474
    12. 12.
      "Molecular basis for the three major forms of human serum vitamin D binding protein (group-specific component)."
      Svasti J. , Kurosky A. , Bennett A. , Bowman B.H.
      Biochemistry18:1611-1617(1979) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 17-31 AND 431-441
    13. 13.
      "Characterization of mutants of the vitamin-D-binding protein/group specific component: GC aborigine (1A1) from Australian aborigines and South African blacks, and 2A9 from south Germany."
      Kofler A. , Braun A. , Jenkins T. , Serjeantson S.W. , Cleve H.
      Vox Sang.68:50-54(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 430-446;VARIANTS GC*1A1 THR-436 AND HIS-445;VARIANT GC*2A9 CYS-445
    14. 14.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    15. 15.
      "Molecular analysis of the gene for the human vitamin-D-binding protein (group-specific component): allelic differences of the common genetic GC types."
      Braun A. , Bichlmaier R. , Cleve H.
      Hum. Genet.89:401-406(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS GC*2; GC*1F AND GC*1S
    16. 16.
      "A structural basis for the unique binding features of the human vitamin D-binding protein."
      Verboven C. , Rabijns A. , De Maeyer M. , Van Baelen H. , Bouillon R. , De Ranter C.
      Nat. Struct. Biol.9:131-136(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.31 ANGSTROMS) OF 29-473
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