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Index > Protein center > Vwf(Gene name) > Mouse
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  • Vwf (Gene name),
  • von Willebrand factor (Protein name ),  VWF_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    Vwf;
    Protein name:
    von Willebrand factor(vWF);
    Alternative:

    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Multimeric. Interacts with F8.
    Function:
    Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma.
    Subcellular Location:
    Secreted Secreted extracellular space extracellular matrix Localized to storage granules.
    Protein Attributes:
    Sequence length:
    2813
    Sequence:
    50:
    MNPFRYEICL | LVLALTWPGT | LCTEKPRDRP | STARCSLFGD | DFINTFDETM | 
    100:
    YSFAGGCSYL | LAGDCQKRSF | SILGNFQDGK | RMSLSVYLGE | FFDIHLFANG | 
    150:
    TVMQGDQSIS | MPYASQGLYL | ELEAGYYKLS | SETFGFAARI | DGNGNFQVLM | 
    200:
    SDRHFNKTCG | LCGDFNIFAE | DDFRTQEGTL | TSDPYDFANS | WALSSEEQRC | 
    250:
    KRASPPSRNC | ESSSGDMHQA | MWEQCQLLKT | ASVFARCHPL | VDPESFVALC | 
    300:
    EKILCTCATG | PECACPVLLE | YARTCAQEGM | VLYGWTDHSA | CRPACPAGME | 
    350:
    YKECVSPCPR | TCQSLSINEV | CQQQCVDGCS | CPEGELLDED | RCVQSSDCPC | 
    400:
    VHAGKRYPPG | TSLSQDCNTC | ICRNSLWICS | NEECPGECLV | TGQSHFKSFD | 
    450:
    NRYFTFSGIC | QYLLARDCED | HTFSIVIETM | QCADDPDAVC | TRSVSVRLSA | 
    500:
    LHNSLVKLKH | GGAVGIDGQD | VQLPFLQGDL | RIQHTVMASV | RLSYAEDLQM | 
    550:
    DWDGRGRLLV | KLSPVYSGKT | CGLCGNYNGN | KGDDFLTPAG | LVEPLVVDFG | 
    600:
    NAWKLQGDCS | DLRRQHSDPC | SLNPRLTRFA | EEACALLTSS | KFEACHHAVS | 
    650:
    PLPYLQNCRY | DVCSCSDSRD | CLCNAVANYA | AECARKGVHI | GWREPGFCAL | 
    700:
    GCPQGQVYLQ | CGNSCNLTCR | SLSLPDEECS | EVCLEGCYCP | PGLYQDERGD | 
    750:
    CVPKAQCPCY | YDGELFQPAD | IFSDHHTMCY | CEDGFMHCTT | SGTLGSLLPD | 
    800:
    TVLSSPLSHR | SKRSLSCRPP | MVKLVCPADN | PRAQGLECAK | TCQNYDLERM | 
    850:
    SLGCVSGCLC | PPGMVRHENK | CVALERCPCF | HQGAEYAPGD | TVKIGCNTCV | 
    900:
    CRERKWNCTN | HVCDATRSAI | GMAHYLTFDG | LKYLFPGECQ | YVLVYDYCGS | 
    950:
    NPGTFQILVG | NEGCSYPSVK | CRKRVTILVD | GGELELFDGE | VNVKRPLRDE | 
    1000:
    SHFEVVESGR | YVILLLGQAL | SVVWDHHLSI | SVVLKHTYQE | QVCGLCGNFD | 
    1050:
    GIQNNDSTTS | SLQVEEDPVN | FGNSWKVSSQ | CADTRKLSLD | VSPATCHNNI | 
    1100:
    MKQTMVDSAC | RILTSDVFQG | CNRLVDPEPY | LDICIYDTCS | CESIGDCACF | 
    1150:
    CDTIAAYAHV | CAQHGQVVAW | RTPTLCPQSC | EEKNVRENGY | ECEWRYNSCA | 
    1200:
    PACPVTCQHP | EPLACPVQCV | EGCHAHCPPG | RILDELLQTC | VDPQDCPVCE | 
    1250:
    VAGRRLAPGK | KITLSPDDPA | HCQNCHCDGV | NLTCEACQEP | GGLVAPPTDA | 
    1300:
    PVSSTTPYVE | DTPEPPLHNF | YCSKLLDLVF | LLDGSSMLSE | AEFEVLKAFV | 
    1350:
    VGMMERLHIS | QKRIRVAVVE | YHDGSRAYLE | LKARKRPSEL | RRITSQIKYT | 
    1400:
    GSQVASTSEV | LKYTLFQIFG | KIDRPEASHI | TLLLTASQEP | PRMARNLVRY | 
    1450:
    VQGLKKKKVI | VIPVGIGPHA | SLKQIRLIEK | QAPENKAFLL | SGVDELEQRR | 
    1500:
    DEIVSYLCDL | APEAPAPTQP | PQVAHVTVSP | GIAGISSPGP | KRKSMVLDVV | 
    1550:
    FVLEGSDEVG | EANFNKSKEF | VEEVIQRMDV | SPDATRISVL | QYSYTVTMEY | 
    1600:
    AFNGAQSKEE | VLRHVREIRY | QGGNRTNTGQ | ALQYLSEHSF | SPSQGDRVEA | 
    1650:
    PNLVYMVTGN | PASDEIKRLP | GDIQVVPIGV | GPHANMQELE | RISRPIAPIF | 
    1700:
    IRDFETLPRE | APDLVLQTCC | SKEGLQLPTL | PPLPDCSQPL | DVVLLLDGSS | 
    1750:
    SLPESSFDKM | KSFAKAFISK | ANIGPHLTQV | SVIQYGSINT | IDVPWNVVQE | 
    1800:
    KAHLQSLVDL | MQQEGGPSQI | GDALAFAVRY | VTSQIHGARP | GASKAVVIII | 
    1850:
    MDTSLDPVDT | AADAARSNRV | AVFPVGVGDR | YDEAQLRILA | GPGASSNVVK | 
    1900:
    LQQVEDLSTM | ATLGNSFFHK | LCSGFSGVCV | DEDGNEKRPG | DVWTLPDQCH | 
    1950:
    TVTCLANGQT | LLQSHRVNCD | HGPRPSCANS | QSPVRVEETC | GCRWTCPCVC | 
    2000:
    TGSSTRHIVT | FDGQNFKLTG | SCSYVIFQNK | EQDLEVLLHN | GACSPGAKQA | 
    2050:
    CMKSIEIKHA | GVSAELHSNM | EMAVDGRLVL | APYVGENMEV | SIYGAIMYEV | 
    2100:
    RFTHLGHILT | YTPQNNEFQL | QLSPKTFASK | MHGLCGICDE | NGANDFTLRD | 
    2150:
    GTVTTDWKRL | VQEWTVQQPG | YTCQAVPEEQ | CPVSDSSHCQ | VLLSASFAEC | 
    2200:
    HKVIAPATFH | TICQQDSCHQ | ERVCEVIASY | AHLCRTSGVC | VDWRTTDFCA | 
    2250:
    MSCPPSLVYN | HCERGCPRHC | DGNTSFCGDH | PSEGCFCPQH | QVFLEGSCVP | 
    2300:
    EEACTQCVGE | DGVRHQFLET | WVPDHQPCQI | CMCLSGRKIN | CTAQPCPTAR | 
    2350:
    APTCGPCEVA | RLKQSTNLCC | PEYECVCDLF | NCNLPPVPPC | EGGLQPTLTN | 
    2400:
    PGECRPTFTC | DCRKEECKRV | SPPSCPPHRT | PTLRKTQCCD | EYECACSCVN | 
    2450:
    STLSCPLGYL | ASATTNDCGC | TTTTCLPDKV | CVHRGTVYPV | GQFWEEGCDT | 
    2500:
    CTCTDMEDTV | VGLRVVQCSQ | RPCEDSCQPG | FSYVLHEGEC | CGRCLPSACK | 
    2550:
    VVAGSLRGDS | HSSWKSVGSR | WAVPENPCLV | NECVRVEDAV | FVQQRNISCP | 
    2600:
    QLAVPTCPTG | FQLNCETSEC | CPSCHCEPVE | ACLLNGTIIG | PGKSVMVDLC | 
    2650:
    TTCRCIVQTD | AISRFKLECR | KTTCEACPMG | YREEKSQGEC | CGRCLPTACT | 
    2700:
    IQLRGGRIMT | LKQDETFQDG | CDSHLCRVNE | RGEYIWEKRV | TGCPPFDEHK | 
    2750:
    CLAEGGKIVK | IPGTCCDTCE | EPDCKDITAK | VQYIKVGDCK | SQEEVDIHYC | 
    2800:
    QGKCASKAVY | SIDIEDVQEQ | CSCCLPSRTE | PMRVPLHCTN | GSVVYHEVIN | 
    2813:
    AMQCRCSPRN | CSK
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    Pfam:
    SMR:
    KEGG:
    String:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse vWF
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    E0833h
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    ELISA Kit for Mouse vWF
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    E0833r
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    ELISA Kit for Mouse vWF
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    E0833m
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    ELISA Kit for Mouse vWF
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    E0833p
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    ELISA Kit for Mouse vWF
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    E0833d
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    ELISA Kit for Mouse vWF
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    E0833b
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    96T
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    CLIA Kit for Mouse vWF
    MSDS:
    Please sign in first.
    CLIA Kit for Mouse vWF
    Cat.:
    U0833r
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Mouse vWF
    Cat.:
    U0833d
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Mouse vWF
    Cat.:
    U0833p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Mouse vWF
    Cat.:
    U0833m
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    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
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    CLIA Kit for Mouse vWF
    Cat.:
    U0833h
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    Packing:
    96T
    Polyclonal Antibody for Mouse vWF
    Cat.:
    P0833Rb-m
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse vWF
    Polyclonal Antibody for Mouse vWF
    Polyclonal Antibody for Mouse vWF
    Cat.:
    P0833Rb-r
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse vWF
    Cat.:
    P0833Rb-h
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse vWF
    Monoclonal Antibody for Mouse vWF
    Monoclonal Antibody for Mouse vWF
    Monoclonal Antibody for Mouse vWF
    Monoclonal Antibody for Mouse vWF
    Monoclonal Antibody for Mouse vWF
    Monoclonal Antibody for Mouse vWF
    Protein for Mouse vWF
    Protein for Mouse vWF
    Protein for Mouse vWF
    Protein for Mouse vWF
    Protein for Mouse vWF
    Protein for Mouse vWF

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Cloning of full-length murine von Willebrand factor cDNA."
      Chitta M.S. , Duhe R.J. , Kermode J.C.
      Submitted (2002-12) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      strain: C57BL/6.
      tissue: Lung.
    2. 2.
      "Murine von Willebrand factor."
      Lenting P.J. , Westein E. , de Groot P.G. , Denis C.V.
      Submitted (2003-07) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      strain: BALB/c.
    3. 3.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      strain: C57BL/6J.
      tissue: Hippocampus.
    4. 4.
      "Variance of molecular datings, evolution of rodents and the phylogenetic affinities between Ctenodactylidae and Hystricognathi."
      Huchon D. , Catzeflis F.M. , Douzery E.J.P.
      Proc. R. Soc. B267:393-402(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1238-1658 (ISOFORM 1)
    5. 5.
      "von Willebrand disease in the RIIIS/J mouse is caused by a defect outside of the von Willebrand factor gene."
      Nichols W.C. , Cooney K.A. , Mohlke K.L. , Ballew J.D. , Yang A. , Bruck M.E. , Reddington M. , Novak E.K. , Swank R.T. , Ginsburg D.
      Blood83:3225-3231(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1298-1684 (ISOFORM 1)
      strain: BALB/c.
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
    7. 7.
      "Persistence of platelet thrombus formation in arterioles of mice lacking both von Willebrand factor and fibrinogen."
      Ni H. , Denis C.V. , Subbarao S. , Degen J.L. , Sato T.N. , Hynes R.O. , Wagner D.D.
      J. Clin. Invest.106:385-392(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE
    8. 8.
      "An experimental model to study the in vivo survival of von Willebrand factor. Basic aspects and application to the R1205H mutation."
      Lenting P.J. , Westein E. , Terraube V. , Ribba A.-S. , Huizinga E.G. , Meyer D. , de Groot P.G. , Denis C.V.
      J. Biol. Chem.279:12102-12109(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF ARG-1205;TISSUE SPECIFICITY
      strain: C57BL/6J.
    9. 9.
      "von Willebrand factor, platelets and endothelial cell interactions."
      Ruggeri Z.M.
      J. Thromb. Haemost.1:1335-1342(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
    10. 10.
      "The snake venom protein botrocetin acts as a biological brace to promote dysfunctional platelet aggregation."
      Fukuda K. , Doggett T. , Laurenzi I.J. , Liddington R.C. , Diacovo T.G.
      Nat. Struct. Mol. Biol.12:152-159(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 1261-1468 IN COMPLEX WITH SNAKE VENOM BOTROCETIN;DISULFIDE BOND
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