WAS ELISA Kit for Human(Homo sapiens) | EIAab.comWAS ELISA Kit for Human(Homo sapiens)

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Index > Protein center > WAS(Gene name) > Human

WAS (Gene name),

Wiskott-Aldrich syndrome protein (Protein name ), WASP_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

WAS(IMD2);

Protein name:

Wiskott-Aldrich syndrome protein(WASp);

Alternative:

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Binds to CDC42, RAC, NCK, FYN, SRC kinase FGR, BTK, ABL, PSTPIP1, WIP, and to the p85 subunit of PLC-gamma. Binds the Arp2/3 complex. Interacts (via C-terminus) with ALDOA. Interacts with E.coli EspF(U).

Function:

Effector protein for Rho-type GTPases. Regulates actin filament reorganization via its interaction with the Arp2/3 complex. Important for efficient actin polymerization. Possible regulator of lymphocyte and platelet function. Mediates actin filament reorganization and the formation of actin pedestals upon infection by pathogenic bacteria.

Subcellular Location:

Cytoplasm cytoskeleton

Protein Attributes:

Sequence length:

502

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

502:

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Hs.2157

String:

P42768

KEGG:

hsa:7454

STRING:

9606.ENSP00000365891

Pfam:

PF00786

MIM:

300299

SMR:

P42768

Uniprot:

P42768

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ELISA Kit for Human WASp

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E1917h

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96T

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ELISA Kit for Human WASp

Cat.:

E1917m

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96T

CLIA Kit for Human WASp

Cat.:

U1917m

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96T

CLIA Kit for Human WASp

Cat.:

U1917h

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96T

Polyclonal Antibody for Human WASp

Cat.:

P1917Rb-m

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40ug/0.2ml

Polyclonal Antibody for Human WASp

Cat.:

P1917Rb-h

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human WASp

Protein for Human WASp

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Isolation of a novel gene mutated in Wiskott-Aldrich syndrome."
Derry J.M.J. , Ochs H.D. , Francke U.
Cell78:635-644(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA];TISSUE SPECIFICITY
tissue: T-cell.
2.

Derry J.M.J. , Ochs H.D. , Francke U.
Cell79:923-923(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
3.

"Identification of mutations in the Wiskott-Aldrich syndrome gene and characterization of a polymorphic dinucleotide repeat at DXS6940, adjacent to the disease gene."
Kwan S.-P. , Hagemann T.L. , Radtke B.E. , Blaese R.M. , Rosen F.S.
Proc. Natl. Acad. Sci. U.S.A.92:4706-4710(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANTS WAS TRP-43; MET-45; LEU-58; LYS-133 AND THR-134
4.

"The identification and characterization of two promoters and the complete genomic sequence for the Wiskott-Aldrich syndrome gene."
Hagemann T.L. , Kwan S.-P.
Biochem. Biophys. Res. Commun.256:104-109(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
5.

"The DNA sequence of the human X chromosome."
Ross M.T. , Grafham D.V. , Coffey A.J. , Scherer S. , McLay K. , Muzny D. , Platzer M. , Howell G.R. , Burrows C. , Bird C.P. , Frankish A. , Lovell F.L. , Howe K.L. , Ashurst J.L. , Fulton R.S. , Sudbrak R. , Wen G. , Jones M.C. , more...
Nature434:325-337(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Lymph.
7.

"Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."
Gevaert K. , Goethals M. , Martens L. , Van Damme J. , Staes A. , Thomas G.R. , Vandekerckhove J.
Nat. Biotechnol.21:566-569(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 2-13
tissue: Platelet.
8.

"Direct interaction of the Wiskott-Aldrich syndrome protein with the GTPase Cdc42."
Kolluri R. , Tolias K.F. , Carpenter C.L. , Rosen F.S. , Kirchhausen T.
Proc. Natl. Acad. Sci. U.S.A.93:5615-5618(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CDC42
9.

"WIP, a protein associated with Wiskott-Aldrich syndrome protein, induces actin polymerization and redistribution in lymphoid cells."
Ramesh N. , Anton I.M. , Hartwig J.H. , Geha R.S.
Proc. Natl. Acad. Sci. U.S.A.94:14671-14676(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH WIP
10.

"Phosphorylation of tyrosine 291 enhances the ability of WASp to stimulate actin polymerization and filopodium formation. Wiskott-Aldrich Syndrome protein."
Cory G.O. , Garg R. , Cramer R. , Ridley A.J.
J. Biol. Chem.277:45115-45121(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;PHOSPHORYLATION AT TYR-291 BY HCK;IDENTIFICATION BY MASS SPECTROMETRY;INTERACTION WITH HCK
11.

"Phosphorylation of the WASP-VCA domain increases its affinity for the Arp2/3 complex and enhances actin polymerization by WASP."
Cory G.O.C. , Cramer R. , Blanchoin L. , Ridley A.J.
Mol. Cell11:1229-1239(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-483 AND SER-484;INTERACTION WITH THE ARP2/3 COMPLEX
12.

"Fyn and PTP-PEST-mediated regulation of Wiskott-Aldrich syndrome protein (WASp) tyrosine phosphorylation is required for coupling T cell antigen receptor engagement to WASp effector function and T cell activation."
Badour K. , Zhang J. , Shi F. , Leng Y. , Collins M. , Siminovitch K.A.
J. Exp. Med.199:99-112(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT TYR-291 BY FYN
13.

"Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
Rush J. , Moritz A. , Lee K.A. , Guo A. , Goss V.L. , Spek E.J. , Zhang H. , Zha X.-M. , Polakiewicz R.D. , Comb M.J.
Nat. Biotechnol.23:94-101(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-291;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
14.

"Phosphoproteome of resting human platelets."
Zahedi R.P. , Lewandrowski U. , Wiesner J. , Wortelkamp S. , Moebius J. , Schuetz C. , Walter U. , Gambaryan S. , Sickmann A.
J. Proteome Res.7:526-534(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-291; SER-483 AND SER-484;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Platelet.
15.

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-291; SER-483 AND SER-484;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Leukemic T-cell.
16.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
17.

"Structure of Cdc42 in complex with the GTPase-binding domain of the 'Wiskott-Aldrich syndrome' protein."
Abdul-Manan N. , Aghazadeh B. , Liu G.A. , Majumdar A. , Ouerfelli O. , Siminovitch K.A. , Rosen M.K.
Nature399:379-383(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 230-288 IN COMPLEX WITH CDC42
18.

"Autoinhibition and activation mechanisms of the Wiskott-Aldrich syndrome protein."
Kim A.S. , Kakalis L.T. , Abdul-Manan N. , Liu G.A. , Rosen M.K.
Nature404:151-158(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 242-492;CONFORMATION CHANGE
19.

"Chemical inhibition of N-WASP by stabilization of a native autoinhibited conformation."
Peterson J.R. , Bickford L.C. , Morgan D. , Kim A.S. , Ouerfelli O. , Kirschner M.W. , Rosen M.K.
Nat. Struct. Mol. Biol.11:747-755(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 242-310 IN COMPLEX WITH WISKOSTATIN
20.

"Actin-bound structures of Wiskott-Aldrich syndrome protein (WASP)-homology domain 2 and the implications for filament assembly."
Chereau D. , Kerff F. , Graceffa P. , Grabarek Z. , Langsetmo K. , Dominguez R.
Proc. Natl. Acad. Sci. U.S.A.102:16644-16649(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.08 ANGSTROMS) OF 430-458 IN COMPLEX WITH ACTIN;FUNCTION;SUBUNIT
21.

"A hydrophobic pocket in the active site of glycolytic aldolase mediates interactions with Wiskott-Aldrich syndrome protein."
St-Jean M. , Izard T. , Sygusch J.
J. Biol. Chem.282:14309-14315(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.05 ANGSTROMS) OF 488-502 IN COMPLEX WITH ALDOA
22.

"Structural mechanism of WASP activation by the enterohaemorrhagic E. coli effector EspF(U)."
Cheng H.C. , Skehan B.M. , Campellone K.G. , Leong J.M. , Rosen M.K.
Nature454:1009-1013(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 242-310;FUNCTION;INTERACTION WITH E.COLI ESPF(U)
23.

"Identification of WASP mutations in patients with Wiskott-Aldrich syndrome and isolated thrombocytopenia reveals allelic heterogeneity at the WAS locus."
Kolluri R. , Shehabeldin A. , Peacocke M. , Lamhonwah A.-M. , Teichert-Kuliszewska K. , Weissman S.M. , Siminovitch K.A.
Hum. Mol. Genet.4:1119-1126(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS WAS HIS-30 DEL; LYS-31; MET-75; PRO-82; CYS-86; HIS-86; CYS-97; LYS-133 AND GLU-476
24.

"WASP gene mutations in Wiskott-Aldrich syndrome and X-linked thrombocytopenia."
Derry J.M.J. , Kerns J.A. , Weinberg K.I. , Ochs H.D. , Volpini V. , Estivill X. , Walker A.P. , Francke U.
Hum. Mol. Genet.4:1127-1135(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS THC1 PHE-27; ILE-48 AND LYS-477;VARIANTS WAS MET-75; LEU-86; HIS-86; LYS-131 AND CYS-187
25.

"X-linked thrombocytopenia and Wiskott-Aldrich syndrome are allelic diseases with mutations in the WASP gene."
Villa A. , Notarangelo L. , Macchi P. , Mantuano E. , Cavagni G. , Brugnoni D. , Strina D. , Patrosso M.C. , Ramenghi U. , Sacco M.G. , Ugazio A. , Vezzoni P.
Nat. Genet.9:414-417(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS THC1 VAL-56 AND GLU-236
26.

"Wiskott-Aldrich syndrome: no strict genotype-phenotype correlations but clustering of missense mutations in the amino-terminal part of the WASP gene product."
Schindelhauer D. , Weiss M. , Hellebrand H. , Golla A. , Hergersberg M. , Seger R. , Belohradsky B.H. , Meindl A.
Hum. Genet.98:68-76(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT WAS HIS-86
27.

"Variable expression of WASP in B cell lines of Wiskott-Aldrich syndrome patients."
Remold-O'Donnell E. , Cooley J. , Shcherbina A. , Hagemann T.L. , Kwan S.-P. , Kenney D.M. , Rosen F.S.
J. Immunol.158:4021-4025(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS WAS TRP-43; MET-45; MET-75 AND CYS-86
28.

"Mutation analysis of five Japanese families with Wiskott-Aldrich syndrome and determination of the family members' carrier status using three different methods."
Ariga T. , Yamada M. , Sakiyama Y.
Pediatr. Res.41:535-540(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS WAS LYS-31 AND MET-45
29.

"Absence of expression of the Wiskott-Aldrich syndrome protein in peripheral blood cells of Wiskott-Aldrich syndrome patients."
MacCarthy-Morrogh L. , Gaspar H.B. , Wang Y.-C. , Katz F. , Thompson L. , Layton M. , Jones A.M. , Kinnon C.
Clin. Immunol. Immunopathol.88:22-27(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS WAS MET-75; LEU-84; ASP-89 AND LYS-133
30.

"Defective actin polymerization in EBV-transformed B-cell lines from patients with the Wiskott-Aldrich syndrome."
Facchetti F. , Blanzuoli L. , Vermi W. , Notarangelo L.D. , Giliani S. , Fiorini M. , Fasth A. , Stewart D.M. , Nelson D.L.
J. Pathol.185:99-107(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT WAS VAL-56
31.

"X-linked Wiskott-Aldrich syndrome in a girl."
Parolini O. , Ressmann G. , Haas O.A. , Pawlowsky J. , Gadner H. , Knapp W. , Holter W.
N. Engl. J. Med.338:291-295(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT WAS LYS-133
32.

"Missense C168T in the Wiskott-Aldrich Syndrome protein gene is a common mutation in X-linked thrombocytopenia."
Ho L.L. , Ayling J. , Prosser I. , Kronenberg H. , Iland H. , Joshua D.
Br. J. Haematol.112:76-80(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT THC1 MET-45
33.

"Constitutively activating mutation in WASP causes X-linked severe congenital neutropenia."
Devriendt K. , Kim A.S. , Mathijs G. , Frints S.G.M. , Schwartz M. , Van Den Oord J.J. , Verhoef G.E.G. , Boogaerts M.A. , Fryns J.-P. , You D. , Rosen M.K. , Vandenberghe P.
Nat. Genet.27:313-317(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT XLN PRO-270;CHARACTERIZATION OF VARIANT XLN PRO-270
34.

"Novel mutations in the Wiskott-Aldrich syndrome protein gene and their effects on transcriptional, translational, and clinical phenotypes."
Lemahieu V. , Gastier J.M. , Francke U.
Hum. Mutat.14:54-66(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS WAS ARG-73; CYS-86 AND LYS-133;VARIANTS THC1 MET-75 AND CYS-83
35.

"Missense mutations of the WASP gene cause intermittent X-linked thrombocytopenia."
Notarangelo L.D. , Mazza C. , Giliani S. , D'Aria C. , Gandellini F. , Ravelli C. , Locatelli M.G. , Nelson D.L. , Ochs H.D. , Notarangelo L.D.
Blood99:2268-2269(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS THC1 ARG-58 AND ASN-481
36.

"Wiskott-Aldrich syndrome in Argentina: 17 unique, including nine novel, mutations."
El-Hakeh J. , Rosenzweig S. , Oleastro M. , Basack N. , Berozdnik L. , Molina F. , Rivas E.M. , Zelazko M. , Danielian S.
Hum. Mutat.19:186-187(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS WAS HIS-52 AND TRP-70

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