"A major human epididymis-specific cDNA encodes a protein with sequence homology to extracellular proteinase inhibitors."
Kirchhoff C. , Habben L. , Ivell R. , Krull N.
Biol. Reprod.45:350-357(1991) [PubMed] [Europe PMC] [Abstract]

"The putative ovarian tumour marker gene HE4 (WFDC2), is expressed in normal tissues and undergoes complex alternative splicing to yield multiple protein isoforms."
Bingle L. , Singleton V. , Bingle C.D.
Oncogene21:2768-2773(2002) [PubMed] [Europe PMC] [Abstract]

"The HE4 (WFDC2) protein is a biomarker for ovarian carcinoma."
Hellstrom I. , Raycraft J. , Hayden-Ledbetter M. , Ledbetter J.A. , Schummer M. , McIntosh M. , Drescher C. , Urban N. , Hellstrom K.E.
Cancer Res.63:3695-3700(2003) [PubMed] [Europe PMC] [Abstract]

"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L. , Schick M. , Neubert P. , Schatten R. , Henze S. , Korn B.
Submitted (2004-06) to the EMBL/GenBank/DDBJ databases

"The DNA sequence and comparative analysis of human chromosome 20."
Deloukas P. , Matthews L.H. , Ashurst J.L. , Burton J. , Gilbert J.G.R. , Jones M. , Stavrides G. , Almeida J.P. , Babbage A.K. , Bagguley C.L. , Bailey J. , Barlow K.F. , Bates K.N. , Beard L.M. , Beare D.M. , Beasley O.P. , Bird C.P. , Blakey S.E. , Bridgeman A.M. , Brown A.J. , Buck D. , Burrill W.D. , Butler A.P. , Carder C. , Carter N.P. , Chapman J.C. , Clamp M. , Clark G. , Clark L.N. , Clark S.Y. , Clee C.M. , Clegg S. , Cobley V.E. , Collier R.E. , Connor R.E. , Corby N.R. , Coulson A. , Coville G.J. , Deadman R. , Dhami P.D. , Dunn M. , Ellington A.G. , Frankland J.A. , Fraser A. , French L. , Garner P. , Grafham D.V. , Griffiths C. , Griffiths M.N.D. , Gwilliam R. , Hall R.E. , Hammond S. , Harley J.L. , Heath P.D. , Ho S. , Holden J.L. , Howden P.J. , Huckle E. , Hunt A.R. , Hunt S.E. , Jekosch K. , Johnson C.M. , Johnson D. , Kay M.P. , Kimberley A.M. , King A. , Knights A. , Laird G.K. , Lawlor S. , Lehvaeslaiho M.H. , Leversha M.A. , Lloyd C. , Lloyd D.M. , Lovell J.D. , Marsh V.L. , Martin S.L. , McConnachie L.J. , McLay K. , McMurray A.A. , Milne S.A. , Mistry D. , Moore M.J.F. , Mullikin J.C. , Nickerson T. , Oliver K. , Parker A. , Patel R. , Pearce T.A.V. , Peck A.I. , Phillimore B.J.C.T. , Prathalingam S.R. , Plumb R.W. , Ramsay H. , Rice C.M. , Ross M.T. , Scott C.E. , Sehra H.K. , Shownkeen R. , Sims S. , Skuce C.D. , Smith M.L. , Soderlund C. , Steward C.A. , Sulston J.E. , Swann R.M. , Sycamore N. , Taylor R. , Tee L. , Thomas D.W. , Thorpe A. , Tracey A. , Tromans A.C. , Vaudin M. , Wall M. , Wallis J.M. , Whitehead S.L. , Whittaker P. , Willey D.L. , Williams L. , Williams S.A. , Wilming L. , Wray P.W. , Hubbard T. , Durbin R.M. , Bentley D.R. , Beck S. , Rogers J. more...
Nature414:865-871(2001) [PubMed] [Europe PMC] [Abstract]

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , Yooseph S. , Lu F. , Nusskern D.R. , Shue B.C. , Zheng X.H. , Zhong F. , Delcher A.L. , Huson D.H. , Kravitz S.A. , Mouchard L. , Reinert K. , Remington K.A. , Clark A.G. , Waterman M.S. , Eichler E.E. , Adams M.D. , Hunkapiller M.W. , Myers E.W. , Venter J.C. more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Human epididymis protein 4 (HE4) is a secreted glycoprotein that is overexpressed by serous and endometrioid ovarian carcinomas."
Drapkin R. , von Horsten H.H. , Lin Y. , Mok S.C. , Crum C.P. , Welch W.R. , Hecht J.L.
Cancer Res.65:2162-2169(2005) [PubMed] [Europe PMC] [Abstract]

"Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry."
Ramachandran P. , Boontheung P. , Xie Y. , Sondej M. , Wong D.T. , Loo J.A.
J. Proteome Res.5:1493-1503(2006) [PubMed] [Europe PMC] [Abstract]

"Human epididymis protein-4 (HE-4): a novel cross-class protease inhibitor."
Chhikara N. , Saraswat M. , Tomar A.K. , Dey S. , Singh S. , Yadav S.
PLoS ONE7:E47672-E47672(2012) [PubMed] [Europe PMC] [Abstract]