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Index > Protein center > WNT3A(Gene name) > Human
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  • WNT3A (Gene name),
  • Protein Wnt-3a (Protein name ),  WNT3A_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Related Databases
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  • Gene name:
    WNT3A;
    Protein name:
    Protein Wnt-3a;
    Alternative:

    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with PORCN (By similarity). Interacts with APCDD1 and WLS. Component of the Wnt-Fzd-LRP5-LRP6 signaling complex that contains a WNT protein, a FZD protein and LRP5 or LRP6. Interacts directly in the complex with LRP6.
    Function:
    Ligand for members of the frizzled family of seven transmembrane receptors. Wnt-3 and Wnt-3a play distinct roles in cell-cell signaling during morphogenesis of the developing neural tube.
    Subcellular Location:
    Secreted extracellular space extracellular matrix
    Protein Attributes:
    Sequence length:
    352
    Sequence:
    50:
    MAPLGYFLLL | CSLKQALGSY | PIWWSLAVGP | QYSSLGSQPI | LCASIPGLVP | 
    100:
    KQLRFCRNYV | EIMPSVAEGI | KIGIQECQHQ | FRGRRWNCTT | VHDSLAIFGP | 
    150:
    VLDKATRESA | FVHAIASAGV | AFAVTRSCAE | GTAAICGCSS | RHQGSPGKGW | 
    200:
    KWGGCSEDIE | FGGMVSREFA | DARENRPDAR | SAMNRHNNEA | GRQAIASHMH | 
    250:
    LKCKCHGLSG | SCEVKTCWWS | QPDFRAIGDF | LKDKYDSASE | MVVEKHRESR | 
    300:
    GWVETLRPRY | TYFKVPTERD | LVYYEASPNF | CEPNPETGSF | GTRDRTCNVS | 
    350:
    SHGIDGCDLL | CCGRGHNARA | ERRREKCRCV | FHWCCYVSCQ | ECTRVYDVHT | 
    352:
    CK
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    KEGG:
    Pfam:
    MIM:
    SMR:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Human Protein Wnt-3a
    Cat.:
    E2182h
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human Protein Wnt-3a
    Cat.:
    E2182m
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human Protein Wnt-3a
    Cat.:
    E2182c
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Protein Wnt-3a
    Cat.:
    U2182h
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Protein Wnt-3a
    Cat.:
    U2182c
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Protein Wnt-3a
    Cat.:
    U2182m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Protein Wnt-3a
    Cat.:
    P2182Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Protein Wnt-3a
    Cat.:
    P2182Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Protein Wnt-3a
    Monoclonal Antibody for Human Protein Wnt-3a
    Monoclonal Antibody for Human Protein Wnt-3a
    Monoclonal Antibody for Human Protein Wnt-3a
    Protein for Human Protein Wnt-3a
    Protein for Human Protein Wnt-3a
    Protein for Human Protein Wnt-3a

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    Linearity
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    References
    1. 1.
      "Molecular cloning and characterization of WNT3a and WNT14 clustered in human chromosome 1q42 region."
      Saitoh T. , Hirai M. , Katoh M.
      Biochem. Biophys. Res. Commun.284:1168-1175(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    2. 2.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
    3. 3.
      "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
      Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
    5. 5.
      "Differential expression of human Wnt genes 2, 3, 4, and 7B in human breast cell lines and normal and disease states of human breast tissue."
      Huguet E.L. , McMahon J.A. , McMahon A.P. , Bicknell R. , Harris A.L.
      Cancer Res.54:2615-2621(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 207-330
      tissue: Mammary gland.
    6. 6.
      "Wntless, a conserved membrane protein dedicated to the secretion of Wnt proteins from signaling cells."
      Baenziger C. , Soldini D. , Schuett C. , Zipperlen P. , Hausmann G. , Basler K.
      Cell125:509-522(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH WLS
    7. 7.
      "Reconstitution of a frizzled8.Wnt3a.LRP6 signaling complex reveals multiple Wnt and Dkk1 binding sites on LRP6."
      Bourhis E. , Tam C. , Franke Y. , Bazan J.F. , Ernst J. , Hwang J. , Costa M. , Cochran A.G. , Hannoush R.N.
      J. Biol. Chem.285:9172-9179(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH LRP6 IN THE WNT/FZD/LRP6 COMPLEX
    8. 8.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PALMITOYLATION AT SER-209 BY PORCN;MUTAGENESIS OF SER-209
    9. 9.
      "APCDD1 is a novel Wnt inhibitor mutated in hereditary hypotrichosis simplex."
      Shimomura Y. , Agalliu D. , Vonica A. , Luria V. , Wajid M. , Baumer A. , Belli S. , Petukhova L. , Schinzel A. , Brivanlou A.H. , Barres B.A. , Christiano A.M.
      Nature464:1043-1047(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH APCDD1
    10. 10.
      "Fatty acid modification of Wnt1 and Wnt3a at serine is prerequisite for lipidation at cysteine and is essential for Wnt signalling."
      Doubravska L. , Krausova M. , Gradl D. , Vojtechova M. , Tumova L. , Lukas J. , Valenta T. , Pospichalova V. , Fafilek B. , Plachy J. , Sebesta O. , Korinek V.
      Cell. Signal.23:837-848(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PRELIMINARY CYSTEINE PALMITOYLATION;PALMITOYLATION AT SER-209;GLYCOSYLATION AT ASN-87 AND ASN-298;MUTAGENESIS OF ASN-87; SER-209 AND ASN-298
    11. 11.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISULFIDE BONDS;MUTAGENESIS OF SER-209; CYS-334 AND CYS-335
    12. 12.
      "Single-cell imaging of Wnt palmitoylation by the acyltransferase porcupine."
      Gao X. , Hannoush R.N.
      Nat. Chem. Biol.10:61-68(2014) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: LACK OF PALMITOYLATION AT CYS-77;PALMITOYLATION AT SER-209 BY PORCN
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