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Index > Protein center > WNT4(Gene name) > Human
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  • WNT4 (Gene name),
  • Protein Wnt-4 (Protein name ),  WNT4_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    WNT4(UNQ426/PRO864);
    Protein name:
    Protein Wnt-4;
    Alternative:

    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with PORCN.
    Function:
    Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity). Overexpression may be associated with abnormal proliferation in human breast tissue.
    Subcellular Location:
    Secreted extracellular space extracellular matrix
    Protein Attributes:
    Sequence length:
    351
    Sequence:
    50:
    MSPRSCLRSL | RLLVFAVFSA | AASNWLYLAK | LSSVGSISEE | ETCEKLKGLI | 
    100:
    QRQVQMCKRN | LEVMDSVRRG | AQLAIEECQY | QFRNRRWNCS | TLDSLPVFGK | 
    150:
    VVTQGTREAA | FVYAISSAGV | AFAVTRACSS | GELEKCGCDR | TVHGVSPQGF | 
    200:
    QWSGCSDNIA | YGVAFSQSFV | DVRERSKGAS | SSRALMNLHN | NEAGRKAILT | 
    250:
    HMRVECKCHG | VSGSCEVKTC | WRAVPPFRQV | GHALKEKFDG | ATEVEPRRVG | 
    300:
    SSRALVPRNA | QFKPHTDEDL | VYLEPSPDFC | EQDMRSGVLG | TRGRTCNKTS | 
    350:
    KAIDGCELLC | CGRGFHTAQV | ELAERCSCKF | HWCCFVKCRQ | CQRLVELHTC | 
    351:
    R
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    String:
    KEGG:
    Pfam:
    MIM:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Human Protein Wnt-4
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    E2978h
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    ELISA Kit for Human Protein Wnt-4
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    E2978m
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    ELISA Kit for Human Protein Wnt-4
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    E2978c
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    96T
    ELISA Kit for Human Protein Wnt-4
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    E2978r
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    96T
    CLIA Kit for Human Protein Wnt-4
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    U2978r
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    96T
    CLIA Kit for Human Protein Wnt-4
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    U2978h
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    MSDS:
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    Packing:
    96T
    Range:
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    CLIA Kit for Human Protein Wnt-4
    Cat.:
    U2978m
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    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Protein Wnt-4
    Cat.:
    U2978c
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    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Human Protein Wnt-4
    Polyclonal Antibody for Human Protein Wnt-4
    Cat.:
    P2978Rb-m
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Protein Wnt-4
    Cat.:
    P2978Rb-r
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Protein Wnt-4
    Cat.:
    P2978Rb-h
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    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Protein Wnt-4
    Monoclonal Antibody for Human Protein Wnt-4
    Monoclonal Antibody for Human Protein Wnt-4
    Monoclonal Antibody for Human Protein Wnt-4
    Protein for Human Protein Wnt-4
    Protein for Human Protein Wnt-4
    Protein for Human Protein Wnt-4
    Protein for Human Protein Wnt-4

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Molecular cloning and characterization of six novel human WNT genes."
      Testa T.T. , Mossakowska D.E. , Carter P.S. , Hu E. , Zhu Y. , Kelsell D.P. , Murdock P.R. , Herrity N.C. , Lewis C.J. , Cross D.A. , Culbert A.A. , Reith A.D. , Barnes M.R.
      Submitted (2000-08) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    2. 2.
      "Up-regulation of wnt-4 signaling and dosage-sensitive sex reversal in humans."
      Jordan B.K. , Mohammed M. , Ching S.T. , Delot E. , Chen X.N. , Dewing P. , Swain A. , Rao P.N. , Elejalde B.R. , Vilain E.
      Am. J. Hum. Genet.68:1102-1109(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    3. 3.
      "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
      Clark H.F. , Gurney A.L. , Abaya E. , Baker K. , Baldwin D.T. , Brush J. , Chen J. , Chow B. , Chui C. , Crowley C. , Currell B. , Deuel B. , Dowd P. , Eaton D. , Foster J.S. , Grimaldi C. , Gu Q. , Hass P.E. , more...
      Genome Res.13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
    4. 4.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      tissue: Subthalamic nucleus.
    5. 5.
      "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
      Submitted (2004-10) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
    6. 6.
      "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
      Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Placenta.
    8. 8.
      "Differential expression of human Wnt genes 2, 3, 4, and 7B in human breast cell lines and normal and disease states of human breast tissue."
      Huguet E.L. , McMahon J.A. , McMahon A.P. , Bicknell R. , Harris A.L.
      Cancer Res.54:2615-2621(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 210-329 (ISOFORM 1/2)
      tissue: Mammary gland.
    9. 9.
      Peltoketo H. , Heikkila M. , Vainio S.
      Submitted (2001-01) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-26
    10. 10.
      "Expression of Wnt-4 can be regulated by the Wilms' tumor suppressor gene, WT1."
      Sim U.E. , Smith A. , Szilagi E. , Ioannou P. , Lindsay M.H. , Little M.H.
      Submitted (2001-04) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-26
    11. 11.
      "A WNT4 mutation associated with Muellerian-duct regression and virilization in a 46,XX woman."
      Biason-Lauber A. , Konrad D. , Navratil F. , Schoenle E.J.
      N. Engl. J. Med.351:792-798(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT MULLAPL GLY-216;CHARACTERIZATION OF VARIANT MULLAPL GLY-216
    12. 12.
      "WNT4 deficiency-a clinical phenotype distinct from the classic Mayer-Rokitansky-Kuster-Hauser syndrome: a case report."
      Biason-Lauber A. , De Filippo G. , Konrad D. , Scarano G. , Nazzaro A. , Schoenle E.J.
      Hum. Reprod.22:224-229(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT MULLAPL CYS-83;CHARACTERIZATION OF VARIANT MULLAPL CYS-83
    13. 13.
      "SERKAL syndrome: an autosomal-recessive disorder caused by a loss-of-function mutation in WNT4."
      Mandel H. , Shemer R. , Borochowitz Z.U. , Okopnik M. , Knopf C. , Indelman M. , Drugan A. , Tiosano D. , Gershoni-Baruch R. , Choder M. , Sprecher E.
      Am. J. Hum. Genet.82:39-47(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT SERKAL VAL-114;CHARACTERIZATION OF VARIANT SERKAL VAL-114
    14. 14.
      "Identification and functional analysis of a new WNT4 gene mutation among 28 adolescent girls with primary amenorrhea and Muellerian duct abnormalities: a French collaborative study."
      Philibert P. , Biason-Lauber A. , Rouzier R. , Pienkowski C. , Paris F. , Konrad D. , Schoenle E. , Sultan C.
      J. Clin. Endocrinol. Metab.93:895-900(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT MULLAPL PRO-12;CHARACTERIZATION OF VARIANT MULLAPL PRO-12
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