Gene name:
FAM20B (KIAA0475) ;
Protein name:
Glycosaminoglycan xylosylkinase ;
Alternative:
Xylose kinase ;Protein FAM20B ;
Organism:
Human (Homo sapiens).
General Annotation
Function:
Responsible for the 2-O-phosphorylation of xylose in the glycosaminoglycan-protein linkage region of proteoglycans thereby regulating the amount of mature GAG chains. Sulfated glycosaminoglycans (GAGs), including heparan sulfate and chondroitin sulfate, are synthesized on the so-called common GAG-protein linkage region (GlcUAbeta1-3Galbeta1-3Galbeta1-4Xylbeta1-O-Ser) of core proteins, which is formed by the stepwise addition of monosaccharide residues by the respective specific glycosyltransferases. Xylose 2-o-phosphorylation may influence the catalytic activity of B3GAT3 (GlcAT-I) which completes the precursor tetrasaccharide of GAG-protein linkage regions on which the repeating disaccharide region is synthesized.
Subcellular Location:
Golgi apparatus membrane
Single-pass type II membrane protein
Protein Attributes:
50:
MKLKQRVVLL | AILLVIFIFT | KVFLIDNLDT | SAANREDQRA | FHRMMTGLRV |
100:
ELAPKLDHTL | QSPWEIAAQW | VVPREVYPEE | TPELGAVMHA | MATKKIIKAD |
150:
VGYKGTQLKA | LLILEGGQKV | VFKPKRYSRD | HVVEGEPYAG | YDRHNAEVAA |
200:
FHLDRILGFH | RAPLVVGRFV | NLRTEIKPVA | TEQLLSTFLT | VGNNTCFYGK |
250:
CYYCRETEPA | CADGDIMEGS | VTLWLPDVWP | LQKHRHPWGR | TYREGKLARW |
300:
EYDESYCDAV | KKTSPYDSGP | RLLDIIDTAV | FDYLIGNADR | HHYESFQDDE |
350:
GASMLILLDN | AKSFGNPSLD | ERSILAPLYQ | CCIIRVSTWN | RLNYLKNGVL |
400:
KSALKSAMAH | DPISPVLSDP | HLDAVDQRLL | SVLATVKQCT | DQFGMDTVLV |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
ELISA Kit for Human Glycosaminoglycan xylosylkinase
ELISA Kit for Human Glycosaminoglycan xylosylkinase
CLIA Kit for Human Glycosaminoglycan xylosylkinase
CLIA Kit for Human Glycosaminoglycan xylosylkinase
Polyclonal Antibody for Human Glycosaminoglycan xylosylkinase
Polyclonal Antibody for Human Glycosaminoglycan xylosylkinase
Monoclonal Antibody for Human Glycosaminoglycan xylosylkinase
Monoclonal Antibody for Human Glycosaminoglycan xylosylkinase
Protein for Human Glycosaminoglycan xylosylkinase
Protein for Human Glycosaminoglycan xylosylkinase
R&D Technical Data
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Precision
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Recovery
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Linearity
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Cited for : NUCLEOTIDE SEQUENCE [MRNA];SUBCELLULAR LOCATION;CATALYTIC ACTIVITY;FUNCTION
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
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Brain .
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Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
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Hippocampus .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
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Submitted (2005-07) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Brain .
tissue :
Eye .
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : TISSUE SPECIFICITY
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ROLE OF XYLOSE 2-O-PHOSPHORYLATION IN GAG BIOSYNTHESIS
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;TISSUE SPECIFICITY