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Index > Protein center > FAM20B(Gene name) > Human
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  • FAM20B (Gene name),
  • Glycosaminoglycan xylosylkinase (Protein name ),  XYLK_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Gene name:
    FAM20B(KIAA0475);
    Protein name:
    Glycosaminoglycan xylosylkinase;
    Alternative:
    Xylose kinase;Protein FAM20B;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Responsible for the 2-O-phosphorylation of xylose in the glycosaminoglycan-protein linkage region of proteoglycans thereby regulating the amount of mature GAG chains. Sulfated glycosaminoglycans (GAGs), including heparan sulfate and chondroitin sulfate, are synthesized on the so-called common GAG-protein linkage region (GlcUAbeta1-3Galbeta1-3Galbeta1-4Xylbeta1-O-Ser) of core proteins, which is formed by the stepwise addition of monosaccharide residues by the respective specific glycosyltransferases. Xylose 2-o-phosphorylation may influence the catalytic activity of B3GAT3 (GlcAT-I) which completes the precursor tetrasaccharide of GAG-protein linkage regions on which the repeating disaccharide region is synthesized.
    Subcellular Location:
    Golgi apparatus membrane Single-pass type II membrane protein
    Protein Attributes:
    Sequence length:
    409
    Sequence:
    50:
    MKLKQRVVLL | AILLVIFIFT | KVFLIDNLDT | SAANREDQRA | FHRMMTGLRV | 
    100:
    ELAPKLDHTL | QSPWEIAAQW | VVPREVYPEE | TPELGAVMHA | MATKKIIKAD | 
    150:
    VGYKGTQLKA | LLILEGGQKV | VFKPKRYSRD | HVVEGEPYAG | YDRHNAEVAA | 
    200:
    FHLDRILGFH | RAPLVVGRFV | NLRTEIKPVA | TEQLLSTFLT | VGNNTCFYGK | 
    250:
    CYYCRETEPA | CADGDIMEGS | VTLWLPDVWP | LQKHRHPWGR | TYREGKLARW | 
    300:
    EYDESYCDAV | KKTSPYDSGP | RLLDIIDTAV | FDYLIGNADR | HHYESFQDDE | 
    350:
    GASMLILLDN | AKSFGNPSLD | ERSILAPLYQ | CCIIRVSTWN | RLNYLKNGVL | 
    400:
    KSALKSAMAH | DPISPVLSDP | HLDAVDQRLL | SVLATVKQCT | DQFGMDTVLV | 
    409:
    EDRMPLSHL
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    String:
    UniGene:
    KEGG:
    MIM:
    Pfam:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Human Glycosaminoglycan xylosylkinase
    Cat.:
    E14748h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human Glycosaminoglycan xylosylkinase
    Cat.:
    E14748m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Glycosaminoglycan xylosylkinase
    Cat.:
    U14748h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Glycosaminoglycan xylosylkinase
    Cat.:
    U14748m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Glycosaminoglycan xylosylkinase
    Polyclonal Antibody for Human Glycosaminoglycan xylosylkinase
    Monoclonal Antibody for Human Glycosaminoglycan xylosylkinase
    Monoclonal Antibody for Human Glycosaminoglycan xylosylkinase
    Protein for Human Glycosaminoglycan xylosylkinase
    Protein for Human Glycosaminoglycan xylosylkinase

    R&D Technical Data
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    Precision
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    Recovery
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      "FAM20B is a kinase that phosphorylates xylose in the glycosaminoglycan-protein linkage region."
      Koike T. , Izumikawa T. , Tamura J. , Kitagawa H.
      Biochem. J.421:157-162(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];SUBCELLULAR LOCATION;CATALYTIC ACTIVITY;FUNCTION
    2. 2.
      "Characterization of cDNA clones in size-fractionated cDNA libraries from human brain."
      Seki N. , Ohira M. , Nagase T. , Ishikawa K. , Miyajima N. , Nakajima D. , Nomura N. , Ohara O.
      DNA Res.4:345-349(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Brain.
    3. 3.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Hippocampus.
    4. 4.
      "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
      Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Brain.
      tissue: Eye.
    7. 7.
      "FAM20: an evolutionarily conserved family of secreted proteins expressed in hematopoietic cells."
      Nalbant D. , Youn H. , Nalbant S.I. , Sharma S. , Cobos E. , Beale E.G. , Du Y. , Williams S.C.
      BMC Genomics6:11-11(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
    8. 8.
      "2-o-phosphorylation of xylose and 6-O-sulfation of galactose in the protein linkage region of glycosaminoglycans influence the glucuronyltransferase-I activity involved in the linkage region synthesis."
      Tone Y. , Pedersen L.C. , Yamamoto T. , Izumikawa T. , Kitagawa H. , Nishihara J. , Tamura J. , Negishi M. , Sugahara K.
      J. Biol. Chem.283:16801-16807(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ROLE OF XYLOSE 2-O-PHOSPHORYLATION IN GAG BIOSYNTHESIS
    9. 9.
      "Identification of phosphatase that dephosphorylates xylose in the glycosaminoglycan-protein linkage region of proteoglycans."
      Koike T. , Izumikawa T. , Sato B. , Kitagawa H.
      J. Biol. Chem.289:6695-6708(2014) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY
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