ZEB1 ELISA Kit for Human(Homo sapiens) | EIAab.comZEB1 ELISA Kit for Human(Homo sapiens)

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Index > Protein center > ZEB1(Gene name) > Human

ZEB1 (Gene name),

Zinc finger E-box-binding homeobox 1 (Protein name ), ZEB1_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

ZEB1(AREB6;TCF8);

Protein name:

Zinc finger E-box-binding homeobox 1;

Alternative:

Negative regulator of IL2;NIL-2-A zinc finger protein;Transcription factor 8(TCF-8);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts (via N-terminus) with SMARCA4/BRG1.

Function:

Acts as a transcriptional repressor. Inhibits interleukin-2 (IL-2) gene expression. Enhances or represses the promoter activity of the ATP1A1 gene depending on the quantity of cDNA and on the cell type. Represses E-cadherin promoter and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. Represses BCL6 transcription in the presence of the corepressor CTBP1. Positively regulates neuronal differentiation. Represses RCOR1 transcription activation during neurogenesis. Represses transcription by binding to the E box (5'-CANNTG-3'). Promotes tumorigenicity by repressing stemness-inhibiting microRNAs.

Subcellular Location:

Nucleus

Protein Attributes:

Sequence length:

1124

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

750:

800:

850:

900:

950:

1000:

1050:

1100:

1124:

QASSLGQKVG | ESSEQVSEEK | TNEA

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Hs.124503

STRING:

9606.ENSP00000319248

SMR:

P37275

String:

P37275

Pfam:

PF00046

KEGG:

hsa:6935

MIM:

189909

Uniprot:

P37275

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ELISA Kit for Human Zinc finger E-box-binding homeobox 1

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ELISA Kit for Human Zinc finger E-box-binding homeobox 1

Cat.:

E14970h

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Manual:

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96T

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ELISA Kit for Human Zinc finger E-box-binding homeobox 1

MSDS:

Please sign in first.

ELISA Kit for Human Zinc finger E-box-binding homeobox 1

Cat.:

E14970m

Price:

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Manual:

Looking for manual.

MSDS:

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Packing:

96T

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CLIA Kit for Human Zinc finger E-box-binding homeobox 1

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CLIA Kit for Human Zinc finger E-box-binding homeobox 1

MSDS:

Please sign in first.

CLIA Kit for Human Zinc finger E-box-binding homeobox 1

Cat.:

U14970m

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Human Zinc finger E-box-binding homeobox 1

Cat.:

U14970h

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

Polyclonal Antibody for Human Zinc finger E-box-binding homeobox 1

Monoclonal Antibody for Human Zinc finger E-box-binding homeobox 1

Protein for Human Zinc finger E-box-binding homeobox 1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Transcription factors positively and negatively regulating the Na,K-ATPase alpha 1 subunit gene."
Watanabe Y. , Kawakami K. , Hirayama Y. , Nagano K.
J. Biochem.114:849-855(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
2.

"A human zinc finger homeodomain protein homologous to the chicken delta-crystallin enhancer binding protein, delta EF1."
Bachman N.J. , Scarpulla R.C.
Submitted (1994-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
3.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-798 (ISOFORM 5)
tissue: Brain.
tissue: Thalamus.
4.

"The DNA sequence and comparative analysis of human chromosome 10."
Deloukas P. , Earthrowl M.E. , Grafham D.V. , Rubenfield M. , French L. , Steward C.A. , Sims S.K. , Jones M.C. , Searle S. , Scott C. , Howe K. , Hunt S.E. , Andrews T.D. , Gilbert J.G.R. , Swarbreck D. , Ashurst J.L. , Taylor A. , Battles J. , more...
Nature429:375-381(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
7.

"Identification of a zinc finger protein that inhibits IL-2 gene expression."
Williams T.M. , Moolten D. , Burlein J. , Romano J. , Bhaerman R. , Godillot A. , Mellon M. , Rauscher F.J. III , Kant J.A.
Science254:1791-1794(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 390-1124
8.

"Mutations in TCF8 cause posterior polymorphous corneal dystrophy and ectopic expression of COL4A3 by corneal endothelial cells."
Krafchak C.M. , Pawar H. , Moroi S.E. , Sugar A. , Lichter P.R. , Mackey D.A. , Mian S. , Nairus T. , Elner V. , Schteingart M.T. , Downs C.A. , Kijek T.G. , Johnson J.M. , Trager E.H. , Rozsa F.W. , Mandal M.N.A. , Epstein M.P. , Vollrath D. , more...
Am. J. Hum. Genet.77:694-708(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN PPCD3
9.

"Pc2-mediated sumoylation of Smad-interacting protein 1 attenuates transcriptional repression of E-cadherin."
Long J. , Zuo D. , Park M.
J. Biol. Chem.280:35477-35489(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUMOYLATION AT LYS-347 AND LYS-774
10.

"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Olsen J.V. , Blagoev B. , Gnad F. , Macek B. , Kumar C. , Mortensen P. , Mann M.
Cell127:635-648(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
11.

"A quantitative atlas of mitotic phosphorylation."
Dephoure N. , Zhou C. , Villen J. , Beausoleil S.A. , Bakalarski C.E. , Elledge S.J. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-322;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
12.

"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
13.

"The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs."
Wellner U. , Schubert J. , Burk U.C. , Schmalhofer O. , Zhu F. , Sonntag A. , Waldvogel B. , Vannier C. , Darling D. , zur Hausen A. , Brunton V.G. , Morton J. , Sansom O. , Schuler J. , Stemmler M.P. , Herzberger C. , Hopt U. , Keck T. , more...
Nat. Cell Biol.11:1487-1495(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
14.

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-642; SER-679 AND THR-702;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Leukemic T-cell.
15.

"ZEB1 and CtBP form a repressive complex at a distal promoter element of the BCL6 locus."
Papadopoulou V. , Postigo A. , Sanchez-Tillo E. , Porter A.C. , Wagner S.D.
Biochem. J.427:541-550(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
16.

"ZEB1 represses E-cadherin and induces an EMT by recruiting the SWI/SNF chromatin-remodeling protein BRG1."
Sanchez-Tillo E. , Lazaro A. , Torrent R. , Cuatrecasas M. , Vaquero E.C. , Castells A. , Engel P. , Postigo A.
Oncogene29:3490-3500(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH SMARCA4;TISSUE SPECIFICITY
17.

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-679;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
18.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
19.

"Solution structure of the homeobox domain from human NIL-2-A zinc finger protein, transcription factor 8."
RIKEN structural genomics initiative (RSGI)
Submitted (2007-04) to the PDB data bank

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 583-642
20.

"Missense mutations in TCF8 cause late-onset Fuchs corneal dystrophy and interact with FCD4 on chromosome 9p."
Riazuddin S.A. , Zaghloul N.A. , Al-Saif A. , Davey L. , Diplas B.H. , Meadows D.N. , Eghrari A.O. , Minear M.A. , Li Y.J. , Klintworth G.K. , Afshari N. , Gregory S.G. , Gottsch J.D. , Katsanis N.
Am. J. Hum. Genet.86:45-53(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS FECD6 THR-78; ALA-649; PRO-810; PRO-840 AND THR-905

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