Eating eggs with more cholesterol increases the risk of cardiovascular disease

Claudia Staubert, a nutrition expert at the University of Pennsylvania, said that as the number of eggs a person eats increases, so does the risk of cardiovascular disease.
Researchers tracked the diets, health and lifestyle habits of nearly 50,000 adults across the country for 35 years and found a link between high cholesterol intake and poor health.
Current dietary guidelines in the United States don't give advice on how many eggs a person should eat each day. Claudia said the guidelines go no further because some experts believe high cholesterol is due to saturated fat, not eggs. According to the U.S. department of agriculture, one egg contains nearly 180 milligrams of cholesterol, while the maximum daily intake is 300 milligrams. While the new egg study did not make specific recommendations for egg or cholesterol consumption, every additional 300 mg of cholesterol consumed after baseline was positively associated with an increased risk of cardiovascular disease.
"Eggs contain nutrients that are good for vision and bone health, and it makes sense to eat a few eggs a week," Claudia said. But people should avoid eating more than one egg or egg-related food every day. Nutrition is moderation and balance.
The data also showed that the exercise and other health-promoting habits observed in the study did not change the association between cholesterol in a person's diet and the risk of cardiovascular disease.
"This is a very representative study," Claudia said. "Even in people who eat a healthy diet, the harmful effects of high cholesterol intake cannot be eliminated."

CBX4 Alleviates Senescence and Osteoarthritis

As we get old, the chondrocytes in the joints will slowly age, and the cartilage mucus that acts as a lubricant will also decrease, causing joint pain, stiffness, and even osteoarthritis. Studies have shown that an important cause of osteoarthritis is the aging and functional deterioration of mesenchymal stem (precursor) cells, chondrocytes, and synoviocytes in the joints.
Researchers from the Institute of Biophysics of the Chinese Academy of Sciences examined and compared gene expression levels in young and old mesenchymal stem cells. They found that in the cell line of the elderly, one of the components of the PRC1 protein complex, CBX4 protein expression was lower, significantly lower than the young cell line. Later, they detected the primary mesenchymal stem cells isolated from the elderly tissue and found the same phenomenon.
Using the CRISPR/Cas9 technology to knockout of CBX4, the researchers found that mesenchymal stem cells lacking CBX4 did accelerate aging. The researchers cloned the CBX4 gene coding sequence into a lentiviral expression vector. When lentiviral vectors loaded with the CBX4 gene coding sequence were introduced into senescent human mesenchymal stem cells, these stem cells became more "young" and restored the characteristics of rapid growth. The researchers pointed out that this may be because CBX4 prevents the excessive synthesis of intracellular proteins, thereby slowing the rate of cellular aging.
In addition to cell-level experiments, the researchers conducted animal experiments. They cut the anterior cruciate ligament of the mouse to simulate the occurrence of osteoarthritis. The lentiviral vector overexpressing CBX4 was subsequently injected into the joint space of the mouse. It was found that the proportion of senescent cells in the joint was reduced, the cartilage regeneration was obvious, the inflammatory reaction was also suppressed, and the symptoms of osteoarthritis were effectively alleviated.
This study is......

An enzyme helps to diffuse ovarian cancer

Ovarian cancer is one of the common cancers in women. Because it is in the abdominal cavity, so it is difficult to be diagnosed. If it is found early, chemotherapy has a better therapeutic effect on ovarian cancer. However, once it metastasizes (diffusion), it becomes resistant to chemotherapy and is more lethal.
When ovarian cancer spreads, it often moves to the omentum, an apron that covers the small intestine. The omentum is rich in fat cells, and previous studies have found that the free fatty acids produced by these cells can increase the spread of cancer. A team from the University of Oxford found that ovarian cancer cells only proliferate when an enzyme called SIK2 is present. This enzyme plays a role in burning fat to produce energy. This process is for cancer cells to survive in the omentum. Required.
The results showed that the level of SIK2 in the secondary tumor of the omentum was significantly higher than that in the ovarian primary tumor.
A series of experiments have confirmed that SIK2 not only plays a key role in growing ovarian tumors, but also plays a role in their metastatic spread to the greater omentum, where they become more deadly.
"SIK2 is an important target for future treatment because it provides energy to cancer cells and increases their quantity. Our experiments show that inhibition of SIK2 can destroy these pathways, which reduces cancer in humans. And the possibility of cell proliferation and recurrence." the researchers said.
EIAAB SCIENCE INC, WUHAN has developed SIK2 protein, antibody and ELISA kit.
Welcome scientific research workers to choose and purchase.

Stabilizing the ends of chromosomes can treat age-related diseases

A study led by researchers at Harvard medical school has uncovered a possible new strategy for treating age-related diseases. The shortening of telomeres, one of the components necessary for chromosome replication, damages enzymes called sirtuins, which maintain cell health by influencing the body's metabolic processes and repairing damaged chromosomes. The researchers showed that using a small compound to restore the activity of sirtuins stabilized telomeres, reduced DNA damage and improved liver disease in mouse models. These studies suggest that maintaining telomere length may help cells and tissues regenerate and improve disease outcomes.
Telomeres are also linked to aging and disease；As the organism ages, the telomeres get shorter, and the cells stop dividing and dying. Telomere shortening during human aging is thought to be a potential cause of the decline of stem cells, which have the potential to develop into many different types of cells and help the body heal. Keeping telomeres stable can prevent or slow aging and disease. Telomere shortening can also lead to organ failure and tissue fibrosis, usually in the liver and lungs, because telomere damage prevents cells from dividing and affects cell function.
"Our genetic material is arranged linearly in the structure of chromosomes, the ends of which are specific segments called telomeres. Telomeres are like the plastic tips of a rope, ensuring that the rope doesn't wear out all the time. Elgon sahin, a professor at the University of California's center for molecular biology.
Interestingly, the researchers also found that sirtuins, in turn, affected telomeres. When sahin and his colleagues increased the activity of sirtuins by feeding them small molecules called nicotinamide single nucleotides, telomeres stabilized. However, this requires more data support. "We plan to continue to investigate the molecular mechanisms of telomere-sirtuin interactions to better understand the health and disease ......

Diabetes drugs can reduce cardiovascular and kidney problems

A clinical trial of more than 8,800 people in 20 countries found that common complications of type 2 diabetes in older patients, such as cardiovascular events and retinopathy, were reduced by taking dulaglutide.
Over six years of follow-up, there was a 15 percent reduction in cardiovascular events, such as macrovascular disease, among those who had been taking dulaglutide compared with those taking a placebo, the effect was widespread and was seen in both men and women.
In addition, the drug reduced the rate of retinopathy by 15 percent. "Diabetics are twice as likely as others to develop cardiovascular diseases such as heart disease and stroke, and up to 35 percent of diabetics develop kidney disease," said Mikkaichi, the study's lead researcher and a professor of medicine at Duke University. It has been shown to reduce these events while keeping diabetics' blood sugar levels under control and moderately reducing weight and blood pressure in type 2 diabetics.
The FDA is a documented glucagon-like peptide-1 receptor agonist that is approved to lower blood sugar once a week and works by helping the pancreas release adequate insulin when blood sugar levels are high, slowing gastric emptying after meals, and reducing appetite and weight.
Mikkaichi noted that the study participants were followed for an average of 5.2 years, much longer than in previous trials, and that more than 43 percent of the participants were women. About one-third of the participants had previous cardiovascular disease. In the trial, patients taking dulaglutide lost slightly more weight, had lower blood pressure and a modest increase in heart rate. But the subjects were more likely to have gastrointestinal side effects, including constipation or diarrhea.