Betatrophin, specifically expressed in liver and adipose tissue, is a 198-AA protein that considered as the active component for the treatment of diabetes presently.
The gene was found and submitted to the GeneBank database in 2004. It’s also called hepatocellular carcinoma-associated TD 26, for it is related to the occurrence and progress of hepatocellular carcinoma.
It is also as known as lipasin, angiopoietin-like protein 8, C19orf80 (human), refeeding-induced fat and liver protein, Gm6484 (mouse), which is a novel nutritionally regulated liver-enriched factor, plays a vital role in adipocyte function and/or regulating lipid metabolism. However, it’s not a direct inhibition of lipoprotein lipase activity, but activated ANGPTL3 by promoting hepatocyte ANGPTL3 cracking to regulate blood lipid.
Betatrophin can obviously promote pancreatic β cell proliferation and did not induce insulin resistance. In type 2 diabetic patients, betatrophin levels are increased when compared to age, gender, and BMI (Body mass index) matched controls with similar degree of insulin resistance, and show positively correlated glucose and insulin levels.
Wuhan EIAab Science Co.,Ltd is strong in technology, product, dedicated to provide quality and reliable for all users of products. The Betatrophin ELISA Kit for human (Cat No.E11644h) and mouse (Cat No.E11644m) can be used to detect the target protein level in samples with high sensitivity and specificity. A lot of these kits have been sold, and been the vast number of customer recognition and praise, the citations may be the best proof (http://www.eiaab.com/entries/detail/BETAT_HUMAN). Moreover, the human Betatrophin ELISA Kit has also been validated by the third party (http://www.eiaab.com/info/detail/496).
There are many other products sold in our company related to the diabetes, such as insulin (Cat No. E0448), leptin (Cat No.E0084), Adiponectin (Cat No.E0605), gastrin (Cat No. E1224), meteorin (Cat No.E13481), meteorin-like protein (Cat No.E7391), Thioredoxin-interacting protein (Cat No.E1162), et al. For more details, please visit our official website (http://www.eiaab.com).
References
[1] Dong XY, Pang XW, Yu ST, et al. Identification of genes differentially expressed in human hepatocellular carcinoma by a modified suppression subtractive hybridization method[J]. Int J Cancer, 2004, 112:239−248.
[2] Ren G, Kim JY, Smas CM. Identification of RIFL, a novel adipocyte-enriched insulin target gene with a role in lipid metabolism[J]. Am J Physiol Endocrinol Metab, 2012, 303:334−351.
[3] Zhang R. Lipasin, a novel nutritionally-regulated liver-enriched factor that regulates serum triglyceride levels[J]. Biochem Biophys Res Commun, 2012, 424:786−792.
[4] Quagliarini F, Wang Y, Kozlitina J, et al. Atypical angiopoietin-like protein that regulates ANGPTL3[J]. Proc Natl Acad Sci USA, 2012, 109:19751−19756.
[5] Yi P, Park JS, Melton DA. Betatrophin: a hormone that controls pancreatic beta cell proliferation[J]. Cell, 2013, 153:747−758.
[6] Musunuru K, Pirruccello JP, Do R, et al. Exome sequencing, ANGPTL3 mutations, and familial combined hypolipidemia[J]. N Engl J Med, 2010, 363:2220−2227.
[7] Fu Z, Berhane F, Fite A, et al. Elevated circulating lipasin/betatrophin in human type 2 diabetes and obesity[J]. Scientific Reports, 2014. 4:1-4.
