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Scientists Discover Non-coding RNA Regulatory Mechanism of Liver Cancer Cell Proliferation
Update time:2017-12-24 17:16:13   【 Font: Large  Medium Small

         Chinese scientists through quantitative proteomics technology found two kinds of non-coding RNA regulation of liver cancer cell proliferation molecule mechanism.

According to reports, non-coding RNA refers to the RNA molecules can not encode the protein. Regulatory non-coding RNA mainly includes microRNA, long-chain non-coding RNA and circular RNA.

         Ge Feng Research Group, Institute of Hydrobiology, Chinese Academy of Sciences for many years committed to the use of quantitative proteomics technology reveals the non-coding RNA molecular regulation network and its mechanism of action. CDR1as is a circular RNA molecule that is involved in the development of a variety of cancer and neurological diseases. Ge Feng research group constructed a CDR1as protein in liver cancer cell regulatory network. It was found that CDR1as can regulate the expression of epidermal growth factor receptor by targeting miR-7 molecules and further affect the proliferation of hepatoma cells, revealing the new molecular mechanism of CDR1as in hepatoma cells.


         HOTAIR is a kind of long-chain non-coding RNA closely related to tumorigenesis. Ge's team built the network of HOTAIR molecules in liver cancer cells. The study found that the promotion of HOTAIR on the proliferation of liver cancer cells through the regulation of opioid growth factor receptor expression to achieve this regulatory mechanism may be ubiquitous in all types of cancer cells.

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        Wu Y, Xiong Q, Li S, et al. Integrated proteomic and transcriptomic analysis revealslong noncoding RNA HOTAIR promotes hepatocellular carcinoma cell proliferation by regulating opioid growth factor receptor (OGFr)[J]. Molecular & Cellular Proteomics, 2017:mcp.RA117.000277.


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