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New progress in hepatitis e vaccine development
Update time:2018-01-31 00:08:48   【 Font: Large  Medium Small

        The viral hepatitis caused by hepatitis virus is divided into a, b, c, d and e. Hepatitis e, also known as amyl hepatitis, is an acute viral hepatitis caused by RNA viruses, which is the main cause of severe liver problems.

         Hepatitis e is spread mainly through contaminated water and person-to-person contact, and is easily popular in areas with poor sanitation. According to the world health organization, about 20 million people are infected with the hepatitis e virus each year, of which more than 3 million people develop acute hepatitis e, and almost 57, 000 die. Among them, for pregnant women, the death rate of hepatitis e is higher. The average person is infected with the disease, with a death rate of about 1 to 3 percent, and a fifth for pregnant women.

        on December 9, 2011, Xiamen university professor NingShao  team developed hepatitis e vaccine for a class of new drug certificate issued by the state food and drug administration approval documents and production, is the first complete international hepatitis e vaccine clinical trials. The principle of the hepatitis a vaccine is the use of giant coli expression system to express hepatitis e virus capsid protein, then after purification of multiple capsid protein composition is a highly complex structure virus-like particles, has a large advantage of immune epitope, so after the immune body, can stimulate the body to produce a lot of blocking antibodies against hepatitis e virus invasion. The virus-like particles are produced by genetic engineering recombinant technology. The products contain no hepatitis e virus and have high safety.

        After a 4.5 year follow-up, the researchers found that they still had antibodies against the hepatitis e virus. It is shown that the hepatitis e vaccine can produce good lasting immunity and significantly reduce the risk of hepatitis e.

         The U.S. centers for disease control and prevention Eyasu Teshale Dr "hepatitis e vaccine could be the spread of the disease prevention and control hepatitis e and new tools", and put forward "is given based on the study of hepatitis e vaccine lasting protection of evidence, now to the realization of hepatitis e vaccine in the field of public health".

         Reference: the world's first hepatitis e vaccine, developed by Jun Zhang Xiamen university, has been proved to be durable and effective


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