It is expected to become a new accurate tumor diagnosis method when near-infrared fluorescence imaging technology is applied to multiple detection in-vivo. The research which was proposed by Zhang fan, professor of chemistry of Fudan University, was published on August 6 in Nature Nanotechnology.

    At present, tissue biopsy has been the main method of diagnosis in clinical medicine. However, there are many risks and hidden dangers. So, it is urgent to find a new technology in the future that allows accurate diagnosis of tumors without surgical biopsy.

    Fluorescence imaging not only has the features of real-time and high spatial resolution, but also can be used to realize simultaneous multi-channel detection of multiple objects under test through multiple fluorescence signals of different wavelengths.

    However, when this imaging technology is used in the actual application of multiple imaging in vivo, people is often not satisfactory with the result. So Zhang Fan's team proposed the method of multiple imaging based on time dimension and realized multiple imaging in vivo by using the rare earth nanometer probe fluorescence signal with fluorescence emission in the second window area of near infrared.

    Compared with the traditional clinical diagnostic techniques by which only one tumor marker can be detected at a time, the time-dimensional imaging method proposed by Zhang Fan's team can quantify multiple tumor markers simultaneously, which significantly improves the detection efficiency. At the same time, the time dimension imaging method which is expected to become a new method for noninvasive cancer diagnosis can not only avoid the risk of metastatic tumor cell directly but also reduce the artificial misjudgment risk caused by traditional method in the process of tissue section, processing and evaluation.