Extreme daytime sleepiness (EDS) is common in the elderly. However, a recent study found that extreme daytime sleepiness may be associated with an increased risk of Alzheimer's disease. The report says people who are sleepy during the day are nearly three times more likely to have beta-amyloid deposits in their brains than those who are not sleepy, and beta-amyloid is the hallmark of Alzheimer's disease.

    This study was published in the journal SLEEP under the title "Excessive daytime sleepiness and napping in cognitively normal adults: associations with subsequent amyloid deposition measured by PiB PET".

    The researcher analyzed data from 124 volunteers aged 60 years to see which reports of daytime sleepiness or nap and were associated with beta-amyloid deposition in the brain.

    The results of the study showed that those who reported daytime sleepiness were three times more likely to develop amyloid deposits. After adjusting for factors such as age, gender, education, and body mass index that may affect daytime sleepiness, the risk of daytime sleepiness is still 2.75 times higher.

    Animal model studies of Alzheimer's disease have shown that limiting nighttime sleep results in more beta-amyloid in the brain and spinal fluid. Some human studies have shown that lack of sleep is associated with increased beta-amyloid content in nerve tissue.

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