Scientists at the University of Cambridge have discovered MC4R variants that prevent 4 million people from getting fat in the UK. The team analyzed the genetic maps of more than 500,000 volunteers in the UK biomedical library.On April 18,2019, the study“Human Gain-of-Function MC4R Variants Show Signaling Bias and Protect against Obesity” was published in cell.
They found that about 6% of British people of European descent had a genetic variant that caused the receptor to remain "on". People with these specific genetic variants weigh an average of 2.5 kilograms less than those without these genetic variants, and their risk of developing type 2 diabetes and heart disease is 50% lower. This means that no matter what lifestyle they have,they are more likely to not gain weight. This MC4R controls the melanocortin receptor 4 in the brain and thus regulates appetite.
The study found the genetic factors that prevent people from overeating, so it is now possible to develop drugs that keep the body slim.
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