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Urinary procollagen III aminoterminal propeptide and β-catenin – New diagnostic biomarkers in solitary functioning kidney?
Update time:2019-02-28 17:58:10   【 Font: Large  Medium Small


Purpose: We aimed at evaluating urinary levels of procollagen III aminoterminal propeptide (PIIINP) and beta-catenin and the relationship between these markers and clinical and laboratory variables in children with a solitary functioning kidney (SFK).

Patients and methods: The study group consisted of 98 (M/F: 62/36) children with an SFK with a median age of 8 years. An age-matched control group contained 54 healthy peers. Urinary levels of procollagen III aminoterminal propeptide and beta-catenin were measured using a commercially available immunoassay kit.

Results: The urinary values of PIIINP (UPIIINP) were significantly increased in patients with SFK versus controls (p < 0.01). Our analysis revealed no significant differences in urinary beta-catenin levels between the SFK patients and control subjects (p > 0.05). Only urinary PIIINP levels were correlated to renal function tests, such as serum creatinine, urea, uric acid, and estimated glomerular filtration rate (p<0.05).

Conclusions: An increased urinary level of PIIINP may indicate early kidney impairment in children with SFK. Urinary beta-catenin does not seem to play any important role as a marker of renal function in children with SFK. Further long-term studies are required in order to evaluate the clinical usefulness of these markers and their predictive value of chronic kidney disease (CKD) progression.

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Source:Advances in Medical Sciences      by K Taranta-Janusz, A Moczulska, H Nosek, et al.
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