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Alstonia scholaris R. Br. Sig nificantly In hibits Ret inoid-Induced Skin Irritation In Vitro and In Vivo
Update time:2015-07-08 23:31:30   【 Font: Large  Medium Small

Topical re tinoids inhibit mat r ix metallopro teinases and acce ler ate co llagen synthesis, thereby triggering antiaging effects in theskin. Howe ver, topical re tinoids can cause se vere skin reactions, including scaling , erythema, papules, and inflammation. The present study demonst rates that the ethanolic bark extract of Al stonia scholar is R. Br. can sig nificantly inhibit all-t rans retinoic acid-induced inflammation in human HaCat ker atinocy te ce lls. Further more, two representative retinoid-induced proinflammatory cytokines, monocy techemoatt ractant protein-1 and interleukin-8, were sig nificantly suppressed by A. scholar is extract(by 82.1% and 26.3% at 100 ppm, and dose-dep endently across the tested concent rations) invitro .In a cumulative irritation patch test , A. scholar is extract decreased re tinol-induced skin ir r i tation, w hile s t rengthening the ability of retinoids to inhibit matrix metalloproteinase-1 expression, which is strongly associated with aging effects. T hese results suggest that A. scholaris is a promising compound that may increase the antiaging function of retinoids while reducing their abilit y to cause skin irritation

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Source:Evidence-Based Complementary and Alternative Medicine      by SJ Lee,SA Cho ,SS An, et al.
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