[Sign in] [Register]   

EIAab logo

EIAab news detail, please contact if you have any questions about online orders and payment.
Alstonia scholaris R. Br. Sig nificantly In hibits Ret inoid-Induced Skin Irritation In Vitro and In Vivo
Update time:2015-07-08 23:31:30   【 Font: Large  Medium Small

Topical re tinoids inhibit mat r ix metallopro teinases and acce ler ate co llagen synthesis, thereby triggering antiaging effects in theskin. Howe ver, topical re tinoids can cause se vere skin reactions, including scaling , erythema, papules, and inflammation. The present study demonst rates that the ethanolic bark extract of Al stonia scholar is R. Br. can sig nificantly inhibit all-t rans retinoic acid-induced inflammation in human HaCat ker atinocy te ce lls. Further more, two representative retinoid-induced proinflammatory cytokines, monocy techemoatt ractant protein-1 and interleukin-8, were sig nificantly suppressed by A. scholar is extract(by 82.1% and 26.3% at 100 ppm, and dose-dep endently across the tested concent rations) invitro .In a cumulative irritation patch test , A. scholar is extract decreased re tinol-induced skin ir r i tation, w hile s t rengthening the ability of retinoids to inhibit matrix metalloproteinase-1 expression, which is strongly associated with aging effects. T hese results suggest that A. scholaris is a promising compound that may increase the antiaging function of retinoids while reducing their abilit y to cause skin irritation

Cited products
Source:Evidence-Based Complementary and Alternative Medicine      by SJ Lee,SA Cho ,SS An, et al.
Hot Genes
ALCAM ACE KSR2 ASPRO C19orf80 Gdf5 Trap1a Atf2
Top Searches
Ubiquitin ELISA Ubiquitin-protein ligase metalloproteinase Asprosin Tumor necrosis TRAP1A vitamin d
Why choose EIAAB
Our products have been quoted by many publications in famous journals such as Cell; Cell Metabolism; Hepatology; Biomaterials.more
Further Information
About us Protein center Bank account Distributors Terms & Conditions Career

Copyright & copy www.eiaab.com2006-2016 All Rights Reserved    EIAab