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Correlation between serum interleukin-31 level and the severity of disease in children with atopic dermatitis
Update time:2014-02-11 18:06:34   【 Font: Large  Medium Small

 

Abstract

Introduction

Atopic dermatitis (AD) is a chronic inflammatory skin disease, characterized by intense itch, typical localization and a specific image of skin lesions. Pathogenesis of pruritus in AD is not fully understood, but recent studies emphasize the role of interleukin-31 (IL-31). This relatively recently described cytokine is considered to be a potential mediator inducing pruritus in AD.

Aim

To assess the correlation of serum IL-31 level and the disease severity in children with AD.

Material and methods

Twenty-five children (16 girls and 9 boys) with AD aged from 4 months to 17 years (mean age: 4.2 years) were enrolled in the study. Disease severity in children with AD was assessed using the SCORAD (Severity SCORing of Atopic Dermatitis) index. Serum IL-31 levels were measured using ELISA with standard kits from EIAab R&D Systems.

Results

Serum IL-31 level was significantly higher in AD children than in healthy children. There was no statistic correlation between serum IL-31 level and the disease severity or itch intensity.

Conclusions

The disease severity and itch intensity do not correlate with serum IL-31 level in children with atopic dermatitis.

Keywords: atopic dermatitis, interleukin 31, SCORAD, pruritus, children
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Source:http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3858655/      by K Siniewicz-Luzeńczyk, A Stańczyk-Przy?uska, K Zeman.
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