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白细胞相关免疫球蛋白样受体-1 在免疫性血小板减少症患儿中的表达
Update time:2014-04-28 18:54:34   【 Font: Large  Medium Small

Abstract: Objective To study the expression of leukocyte-associated Ig-like receptor-1(LAIR-1) in children with immune thrombocytopenia (ITP), in order to explore the possible role of LAIR-1 in the pathogenesis of childhood ITP. MethodsExpression levels of LAIR-1 on CD4+ T cells, CD8+ T cells and CD19+CD20+ B cells of peripheral blood were measured in 40 children with ITP by flow cytometry. Serum level of solubility LAIR-1 (sLAIR-1) was measured using ELISA. Real-time PCR was used to measure LAIR-1 mRNA expression. Thirty-two healthy children served as the control group. Results The percentages of CD19+CD20+ B cells in the ITP group were significantly higher than in the control group (P<0.05). In contrast, the percentage of CD4+ T cells in the ITP group was significantly lower than in the control group (P<0.05). The expression levels of LAIR-1 on CD4+ T cells and CD8+ T cells were significantly lower in the ITP group than in the control group (P<0.05). Serum sLAIR-1 level and LAIR-1 mRNA expression in the ITP group significantly increased compared with the control group (P<0.05). ConclusionsLAIR-1 expression on CD4+ and CD8+ T cells decreases and serum sLAIR-1 level increases in children with ITP, suggesting that LAIR-1 may play an important role in immune imbalance in these children.

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Source:中国当代儿科杂志      by 黄美玲, 李长钢, 王国兵, et al.
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