ABSTRACT

Objective: To compare between the effect of curcuminoids and ginger extract on hypercoagulability, endothelial dysfunction and some ischemic markers in dyslipidemic rabbits.

Methods: 24 male rabbits were randomly allocated into normal control (NC) group, dyslipidemic group fed atherogenic diet for 6 weeks, curcuminoids and ginger groups received their extracts as well as atherogenic diet for 6 weeks.

Results: curcuminoids and ginger extract significantly decreased serum plasminogen activator inhibitor-1 (PAI-1), prothrombin fragment (1+2) (PF1+2), endothelin-1 (ET-1), ischemia modified albumin (IMA), plasma fibrinogen (FIB) while nitric oxide (NO) showed a significant increase as compared to dyslipidemic group. Ginger extract exerted more pronounced effect than curcumionoids regarding serum PAI-1 and PF1+2. Curcuminoids, however demonstrated better effect regarding NO, ET-1 and IMA as compared to ginger extract which may refer to their antioxidant potential. Both extracts demonstrated a similar effect on plasma FIB level.

Conclusion: Ginger seems to improve haemostatic abnormalities in dyslipidemic rabbits better than curcuminoids. The latter exerted similar but weaker effects than ginger, except for their remarkable antioxidant potential and improving endothelial functions. Therefore, co-supplementation of both extracts may synergize their effects in dyslipidemia-induced haemostatic and vascular complications.