Gene name:
C5ar2 (C5l2;Gpr77) ;
Protein name:
C5a anaphylatoxin chemotactic receptor 2 ;
Alternative:
G-protein coupled receptor 77 ;Complement component 5a receptor 2 ;
Organism:
Rat (Rattus norvegicus).
General Annotation
Sub Unit:
Interacts with C3 (the anaphylatoxin peptide C3a and the adipogenic hormone ASP); the interaction occurs with higher affinity for ASP, enhancing the phosphorylation and activation of GPR77, recruitment of ARRB2 to the cell surface and endocytosis of GRP77.
Function:
Receptor for the chemotactic and inflammatory C3a, C4a and C5a anaphylatoxin peptides and also for their dearginated forms ASP/C3adesArg, C4adesArg and C5adesArg respectively. Couples weakly to G(i)-mediated signaling pathways.
Subcellular Location:
Cell membrane
Multi-pass membrane protein
Protein Attributes:
50:
MLNDTTSKDY | EYEYDQEQYS | DLLNVPVDCP | AGNCFSNDAY | LIVLLGLYSV |
100:
IFLVGVPGNT | LLAWVTWKES | RHRLGASWFL | HLTMADLLCC | VSLPFLAVPI |
150:
AQKGHWPYGT | AGCWLLSSIT | VLSMYASVLL | LTGLSGDLFL | LAFRPSWKNA |
200:
DQRTCGVRVV | QVSSWMLALL | LTVPGAVYRK | LLQEHYPPRL | VCGTNYGGSV |
250:
TAEVTITTVR | FLFGFLVPLV | FMASCHGILQ | RQMARRHWPL | GTAVVVGFFI |
300:
CWTPFHLLRV | IIAVASSHSP | LLAWALEAEP | LVTGLALAHS | ALNPIMFLYF |
343:
GRKQLCKSLQ | AACHWALRDL | QDEEESAVTK | VSTSQEMVSE | MPV
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Human
Rat
ELISA Kit for Rat C5a anaphylatoxin chemotactic receptor 2
ELISA Kit for Rat C5a anaphylatoxin chemotactic receptor 2
ELISA Kit for Rat C5a anaphylatoxin chemotactic receptor 2
CLIA Kit for Rat C5a anaphylatoxin chemotactic receptor 2
CLIA Kit for Rat C5a anaphylatoxin chemotactic receptor 2
CLIA Kit for Rat C5a anaphylatoxin chemotactic receptor 2
Polyclonal Antibody for Rat C5a anaphylatoxin chemotactic receptor 2
Polyclonal Antibody for Rat C5a anaphylatoxin chemotactic receptor 2
Polyclonal Antibody for Rat C5a anaphylatoxin chemotactic receptor 2
Monoclonal Antibody for Rat C5a anaphylatoxin chemotactic receptor 2
Monoclonal Antibody for Rat C5a anaphylatoxin chemotactic receptor 2
Monoclonal Antibody for Rat C5a anaphylatoxin chemotactic receptor 2
Protein for Rat C5a anaphylatoxin chemotactic receptor 2
Protein for Rat C5a anaphylatoxin chemotactic receptor 2
Protein for Rat C5a anaphylatoxin chemotactic receptor 2
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
"Molecular cloning and expression of C5L2, a new C5a orphan receptor in sepsis."
Gao H.
,
Neff T.
,
Younkin E.
,
Hoesel M.
,
Man Y.
,
Sarma V.
,
Guo R.-F.
,
Tomlins S.
,
Riedemann N.
,
Speyer C.
,
Zetoune F.
,
Ward P.
Submitted (2004-04) to the EMBL/GenBank/DDBJ databases
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Cited for : NUCLEOTIDE SEQUENCE [MRNA]
strain :
Long Evans .