Flnc CLIA Kit for Mouse(Mus musculus) | EIAab.comFlnc CLIA Kit for Mouse(Mus musculus)

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Flnc (Gene name),

Filamin-C (Protein name ), FLNC_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Flnc(Abpl;Fln2);

Protein name:

Filamin-C(FLN-C);

Alternative:

ABP-L;ABP-280-like protein;Filamin-2;Actin-binding-like protein;Gamma-filamin;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Homodimer (By similarity). Interacts with FLNB, KCND2, INPPL1, ITGB1A, MYOT, MYOZ1 and MYOZ3. Interacts with sarcoglycans SGCD and SGCG. Interacts (via filament repeats 17-18, 20-21 and 24) with USP25 (isoform USP25m only) (By similarity). Interacts with KY. Interacts with IGFN1.

Function:

Muscle-specific filamin, which plays a central role in muscle cells, probably by functioning as a large actin-cross-linking protein. May be involved in reorganizing the actin cytoskeleton in response to signaling events, and may also display structural functions at the Z lines in muscle cells. Critical for normal myogenesis and for maintaining the structural integrity of the muscle fibers.

Subcellular Location:

Cytoplasm Membrane Peripheral membrane protein Cytoplasm cytoskeleton Cytoplasm myofibril sarcomere Z line A small amount localizes at membranes. In striated muscle cells, it predominantly localizes in myofibrillar Z lines, while a minor fraction localizes with subsarcolemme.

Protein Attributes:

Sequence length:

2726

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EKGDYILIVK | WGDESVPGSP | FKVNVP

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

Q8VHX6

Pfam:

PF00307

SMR:

Q8VHX6

UniGene:

Mm.39046

KEGG:

mmu:68794

STRING:

10090.ENSMUSP00000064163

Uniprot:

Q8VHX6

FOR

ELISA Kit for Mouse FLN-C

Cat.:

E11397h

Price:

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Manual:

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MSDS:

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Packing:

96T

Range:

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ELISA Kit for Mouse FLN-C

Cat.:

E11397m

Price:

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Manual:

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MSDS:

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Packing:

96T

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CLIA Kit for Mouse FLN-C

Cat.:

U11397h

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Mouse FLN-C

Cat.:

U11397m

Price:

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MSDS:

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Packing:

96T

Polyclonal Antibody for Mouse FLN-C

Cat.:

P11397Rb-h

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse FLN-C

Monoclonal Antibody for Mouse FLN-C

Protein for Mouse FLN-C

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M. , Goodstadt L. , Hillier L.W. , Zody M.C. , Goldstein S. , She X. , Bult C.J. , Agarwala R. , Cherry J.L. , DiCuccio M. , Hlavina W. , Kapustin Y. , Meric P. , Maglott D. , Birtle Z. , Marques A.C. , Graves T. , Zhou S. , more...
PLoS Biol.7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain: C57BL/6J.
2.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
strain: C57BL/6.
tissue: Brain.
tissue: Embryo.
3.

"Different splice variants of filamin-B affect myogenesis, subcellular distribution, and determine binding to integrin (beta) subunits."
van Der Flier A. , Kuikman I. , Kramer D. , Geerts D. , Kreft M. , Takafuta T. , Shapiro S.S. , Sonnenberg A.
J. Cell Biol.156:361-376(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1687-1800 (ISOFORMS 1 AND 2);DEVELOPMENTAL STAGE
strain: C3H.
4.

"Filamin isogene expression during mouse myogenesis."
Chiang W. , Greaser M.L. , Lyons G.E.
Dev. Dyn.217:99-108(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2535-2726
strain: C3H.
tissue: Myotube.
5.

"Filamin C interacts with the muscular dystrophy KY protein and is abnormally distributed in mouse KY deficient muscle fibres."
Beatham J. , Romero R. , Townsend S.K.M. , Hacker T. , van der Ven P.F.M. , Blanco G.
Hum. Mol. Genet.13:2863-2874(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH KY
6.

"Loss of FilaminC (FLNc) results in severe defects in myogenesis and myotube structure."
Dalkilic I. , Schienda J. , Thompson T.G. , Kunkel L.M.
Mol. Cell. Biol.26:6522-6534(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
7.

"Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
Sweet S.M. , Bailey C.M. , Cunningham D.L. , Heath J.K. , Cooper H.J.
Mol. Cell. Proteomics8:904-912(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2234;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Embryonic fibroblast.
8.

"Identification of a Z-band associated protein complex involving KY, FLNC and IGFN1."
Baker J. , Riley G. , Romero M.R. , Haynes A.R. , Hilton H. , Simon M. , Hancock J. , Tateossian H. , Ripoll V.M. , Blanco G.
Exp. Cell Res.316:1856-1870(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH IGFN1
9.

"Junctional Rab13-binding protein (JRAB) regulates cell spreading via filamins."
Sakane A. , Alamir Mahmoud Abdallah A. , Nakano K. , Honda K. , Kitamura T. , Imoto I. , Matsushita N. , Sasaki T.
Genes Cells18:810-822(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MICALL2

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