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Index > Protein center > SFRP1(Gene name) > Bovine
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  • SFRP1 (Gene name),
  • Secreted frizzled-related protein 1 (Protein name ),  SFRP1_BOVIN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    SFRP1(FRZA);
    Protein name:
    Secreted frizzled-related protein 1(sFRP-1);
    Alternative:
    Frizzled in aorta protein(FrzA protein);
    Organism:
    Bovine (Bos taurus). 
    General Annotation
    Sub Unit:
    Interacts with WNT1, WNT2, WNT4 and WNT8 and FRZD6.
    Function:
    Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP1 decreases intracellular beta-catenin levels (By similarity). Has antiproliferative effects on vascular cells, in vitro and in vivo, and can induce, in vivo, an angiogenic response. In vascular cell cycle, delays the G1 phase and entry into the S phase (By similarity). In kidney development, inhibits tubule formation and bud growth in metanephroi (By similarity). Inhibits WNT1/WNT4-mediated TCF-dependent transcription.
    Subcellular Location:
    Secreted Cell membrane or extracellular matrix-associated. Released by heparin-binding.
    Protein Attributes:
    Sequence length:
    308
    Sequence:
    50:
    MGGGRWAAAG | ALLALAAGLL | AAGSASEYDY | VSFQSDIGAY | QSGRFYTKPP | 
    100:
    QCVDIPADLR | LCHNVGYKRM | VLPNLLEHET | MAEVKQQASS | WVPLLNKNCH | 
    150:
    IGTQVFLCSL | FAPVCLDRPI | YPCRWLCEAV | RDSCEPVMQF | FGFYWPEMLK | 
    200:
    CDKFPEGDVC | IAMTPPNATE | ASKPQGTTVC | PPCDNELKSE | AIIEHLCASE | 
    250:
    FALRMKIKEV | KKENGDKKIV | PKKKKPLKLG | PIKKKELKKL | VLYLKNGADC | 
    300:
    PCHQLDNLSH | HFLIMGRKVK | SQYLLTAIHK | WDKKNKEFKT | FMKKMKNHEC | 
    308:
    PTFQSVFK
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    String:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Bovine sFRP-1
    Cat.:
    E1165m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Bovine sFRP-1
    Cat.:
    E1165h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Bovine sFRP-1
    Cat.:
    E1165b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Bovine sFRP-1
    Cat.:
    E1165r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Bovine sFRP-1
    Cat.:
    E1165c
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Bovine sFRP-1
    Cat.:
    U1165m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Bovine sFRP-1
    Cat.:
    U1165h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Bovine sFRP-1
    Cat.:
    U1165c
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Bovine sFRP-1
    Cat.:
    U1165r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Bovine sFRP-1
    Cat.:
    U1165b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Bovine sFRP-1
    Polyclonal Antibody for Bovine sFRP-1
    Cat.:
    P1165Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Bovine sFRP-1
    Polyclonal Antibody for Bovine sFRP-1
    Cat.:
    P1165Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Bovine sFRP-1
    Cat.:
    P1165Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Bovine sFRP-1
    Monoclonal Antibody for Bovine sFRP-1
    Monoclonal Antibody for Bovine sFRP-1
    Monoclonal Antibody for Bovine sFRP-1
    Monoclonal Antibody for Bovine sFRP-1
    Protein for Bovine sFRP-1
    Protein for Bovine sFRP-1
    Protein for Bovine sFRP-1
    Protein for Bovine sFRP-1
    Protein for Bovine sFRP-1

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    References
    1. 1.
      "Identification and cloning of a secreted protein related to the cysteine-rich domain of frizzled: evidence for a role in endothelial cell growth control."
      Duplaa C. , Jaspard B. , Moreau C. , D'Amore P.A.
      Circ. Res.84:1433-1445(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];SUBCELLULAR LOCATION;TISSUE SPECIFICITY
      tissue: Aortic endothelium.
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