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Index > Protein center > Eif2s1(Gene name) > Rat
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  • Eif2s1 (Gene name),
  • Eukaryotic translation initiation factor 2 subunit 1 (Protein name ),  IF2A_RAT from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    Eif2s1(Eif2a);
    Protein name:
    Eukaryotic translation initiation factor 2 subunit 1;
    Alternative:
    Eukaryotic translation initiation factor 2 subunit alpha(eIF-2-alpha;eIF-2A;eIF-2alpha);
    Organism:
    Rat (Rattus norvegicus). 
    General Annotation
    Sub Unit:
    Heterotrimer composed of an alpha, a beta and a gamma chain. Component of an EIF2 complex at least composed of CELF1/CUGBP1, CALR, CALR3, EIF2S1, EIF2S2, HSP90B1 and HSPA5.
    Function:
    Functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B.
    Subcellular Location:
    Cytoplasmic granule The cytoplasmic granules are stress granules which are a dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress. Co-localizes with NANOS3 in the stress granules.
    Protein Attributes:
    Sequence length:
    315
    Sequence:
    50:
    MPGLSCRFYQ | HKFPEVEDVV | MVNVRSIAEM | GAYVSLLEYN | NIEGMILLSE | 
    100:
    LSRRRIRSIN | KLIRIGRNEC | VVVIRVDKEK | GYIDLSKRRV | SPEEAIKCED | 
    150:
    KFTKSKTVYS | ILRHVAEVLE | YTKDEQLESL | FQRTAWVFDD | KYKRPGYGAY | 
    200:
    DAFKHAVSDP | SILDSLDLNE | DEREVLINNI | NRRLTPQAVK | IRADIEVACY | 
    250:
    GYEGIDAVKE | ALRAGLNCST | ETMPIKINLI | APPRYVMTTT | TLERTEGLSV | 
    300:
    LNQAMAVIKE | KIEEKRGVFN | VQMEPKVVTD | TDETELARQL | ERLERENAEV | 
    315:
    DGDDDAEEME | AKAED
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    SMR:
    String:
    UniGene:
    KEGG:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Rat Eukaryotic translation initiation factor 2 subunit 1
    Cat.:
    E11451h
    Price:
    Please sign in first.
    MSDS:
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    Packing:
    96T
    ELISA Kit for Rat Eukaryotic translation initiation factor 2 subunit 1
    Cat.:
    E11451b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Rat Eukaryotic translation initiation factor 2 subunit 1
    MSDS:
    Please sign in first.
    ELISA Kit for Rat Eukaryotic translation initiation factor 2 subunit 1
    Cat.:
    E11451m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Rat Eukaryotic translation initiation factor 2 subunit 1
    Cat.:
    E11451p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Rat Eukaryotic translation initiation factor 2 subunit 1
    Cat.:
    E11451c
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Rat Eukaryotic translation initiation factor 2 subunit 1
    Cat.:
    E11451r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Rat Eukaryotic translation initiation factor 2 subunit 1
    Cat.:
    U11451p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Rat Eukaryotic translation initiation factor 2 subunit 1
    MSDS:
    Please sign in first.
    CLIA Kit for Rat Eukaryotic translation initiation factor 2 subunit 1
    Cat.:
    U11451b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Rat Eukaryotic translation initiation factor 2 subunit 1
    Cat.:
    U11451h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Rat Eukaryotic translation initiation factor 2 subunit 1
    Cat.:
    U11451c
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Rat Eukaryotic translation initiation factor 2 subunit 1
    Cat.:
    U11451r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Rat Eukaryotic translation initiation factor 2 subunit 1
    Cat.:
    U11451m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Rat Eukaryotic translation initiation factor 2 subunit 1
    Cat.:
    P11451Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Rat Eukaryotic translation initiation factor 2 subunit 1
    Cat.:
    P11451Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Rat Eukaryotic translation initiation factor 2 subunit 1
    Polyclonal Antibody for Rat Eukaryotic translation initiation factor 2 subunit 1
    Polyclonal Antibody for Rat Eukaryotic translation initiation factor 2 subunit 1
    Polyclonal Antibody for Rat Eukaryotic translation initiation factor 2 subunit 1
    Cat.:
    P11451Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Rat Eukaryotic translation initiation factor 2 subunit 1
    Monoclonal Antibody for Rat Eukaryotic translation initiation factor 2 subunit 1
    Monoclonal Antibody for Rat Eukaryotic translation initiation factor 2 subunit 1
    Monoclonal Antibody for Rat Eukaryotic translation initiation factor 2 subunit 1
    Monoclonal Antibody for Rat Eukaryotic translation initiation factor 2 subunit 1
    Monoclonal Antibody for Rat Eukaryotic translation initiation factor 2 subunit 1
    Monoclonal Antibody for Rat Eukaryotic translation initiation factor 2 subunit 1
    Monoclonal Antibody for Rat Eukaryotic translation initiation factor 2 subunit 1
    Protein for Rat Eukaryotic translation initiation factor 2 subunit 1
    Protein for Rat Eukaryotic translation initiation factor 2 subunit 1
    Protein for Rat Eukaryotic translation initiation factor 2 subunit 1
    Protein for Rat Eukaryotic translation initiation factor 2 subunit 1
    Protein for Rat Eukaryotic translation initiation factor 2 subunit 1
    Protein for Rat Eukaryotic translation initiation factor 2 subunit 1
    Protein for Rat Eukaryotic translation initiation factor 2 subunit 1

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    References
    1. 1.
      "Cloning and sequencing of complementary DNAs encoding the alpha-subunit of translational initiation factor eIF-2. Characterization of the protein and its messenger RNA."
      Ernst H. , Duncan R.F. , Hershey J.W.B.
      J. Biol. Chem.262:1206-1212(1987) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];PHOSPHORYLATION
      tissue: Brain.
    2. 2.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Heart.
    3. 3.
      "The eukaryotic initiation factor 2-associated 67-kDa polypeptide (p67) plays a critical role in regulation of protein synthesis initiation in animal cells."
      Ray M.K. , Datta B. , Chakraborty A. , Chattopadhyay A. , Meza-Keuthen S. , Gupta N.K.
      Proc. Natl. Acad. Sci. U.S.A.89:539-543(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH METAP2
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