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Index > Protein center > GPC3(Gene name) > Human
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  • GPC3 (Gene name),
  • Glypican-3 (Protein name ),  GPC3_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Related Databases
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  • Gene name:
    GPC3(OCI5);
    Protein name:
    Glypican-3;
    Alternative:
    Intestinal protein OCI-5;GTR2-2;MXR7;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with DPP4.
    Function:
    Cell surface proteoglycan that bears heparan sulfate. Inhibits the dipeptidyl peptidase activity of DPP4. May be involved in the suppression/modulation of growth in the predominantly mesodermal tissues and organs. May play a role in the modulation of IGF2 interactions with its receptor and thereby modulate its function. May regulate growth and tumor predisposition.
    Subcellular Location:
    Secreted glypican-3 Secreted extracellular space
    Protein Attributes:
    Sequence length:
    580
    Sequence:
    50:
    MAGTVRTACL | VVAMLLSLDF | PGQAQPPPPP | PDATCHQVRS | FFQRLQPGLK | 
    100:
    WVPETPVPGS | DLQVCLPKGP | TCCSRKMEEK | YQLTARLNME | QLLQSASMEL | 
    150:
    KFLIIQNAAV | FQEAFEIVVR | HAKNYTNAMF | KNNYPSLTPQ | AFEFVGEFFT | 
    200:
    DVSLYILGSD | INVDDMVNEL | FDSLFPVIYT | QLMNPGLPDS | ALDINECLRG | 
    250:
    ARRDLKVFGN | FPKLIMTQVS | KSLQVTRIFL | QALNLGIEVI | NTTDHLKFSK | 
    300:
    DCGRMLTRMW | YCSYCQGLMM | VKPCGGYCNV | VMQGCMAGVV | EIDKYWREYI | 
    350:
    LSLEELVNGM | YRIYDMENVL | LGLFSTIHDS | IQYVQKNAGK | LTTTIGKLCA | 
    400:
    HSQQRQYRSA | YYPEDLFIDK | KVLKVAHVEH | EETLSSRRRE | LIQKLKSFIS | 
    450:
    FYSALPGYIC | SHSPVAENDT | LCWNGQELVE | RYSQKAARNG | MKNQFNLHEL | 
    500:
    KMKGPEPVVS | QIIDKLKHIN | QLLRTMSMPK | GRVLDKNLDE | EGFESGDCGD | 
    550:
    DEDECIGGSG | DGMIKVKNQL | RFLAELAYDL | DVDDAPGNSQ | QATPKDNEIS | 
    580:
    TFHNLGNVHS | PLKLLTSMAI | SVVCFFFLVH | 
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    KEGG:
    MIM:
    SMR:
    UniGene:
    Pfam:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human Glypican-3
    Cat.:
    E0971h
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Human Glypican-3
    Cat.:
    E0971m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Human Glypican-3
    Cat.:
    E0971r
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Glypican-3
    Cat.:
    U0971h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Glypican-3
    Cat.:
    U0971m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Glypican-3
    Cat.:
    U0971r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Glypican-3
    Cat.:
    P0971Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Glypican-3
    Cat.:
    P0971Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Glypican-3
    Cat.:
    P0971Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Glypican-3
    Monoclonal Antibody for Human Glypican-3
    Monoclonal Antibody for Human Glypican-3
    Protein for Human Glypican-3
    Protein for Human Glypican-3
    Protein for Human Glypican-3
    Cat.:
    R0971h
    Price:
    Please sign in first.
    Packing:
    1mg
    Purity:
    >90%

    R&D Technical Data

    12% SDS-PAGE analysis

              12% SDS-PAGE analysis

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    Precision
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    Recovery
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    Linearity
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    Citations
    [1].
    Hasan O¨ zkan, Harun Erdal, Erdem Koc-ak, Hu¨ seyin Tutkak, Zihni Karaeren,Mustafa Yakut, and Seyfettin Ko¨ klu¨
    References
    1. 1.
      "Mapping of the Simpson-Golabi-Behmel overgrowth syndrome gene (GPC3) to chromosome X in human and rat by fluorescence in situ hybridization."
      Shen T. , Sonoda G. , Hamid J. , Li M. , Filmus J. , Buick R.N. , Testa J.R.
      Mamm. Genome8:72-72(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    2. 2.
      "Mutations in GPC3, a glypican gene, cause the Simpson-Golabi-Behmel overgrowth syndrome."
      Pilia G. , Hughes-Benzie R.M. , Mackenzie A. , Baybayan P. , Chen E.Y. , Huber R. , Neri G. , Cao A. , Forabosco A. , Schlessinger D.
      Nat. Genet.12:241-247(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1);DISEASE
      tissue: Embryo.
    3. 3.
      "Cloning and characterization of human cDNAs encoding a protein with high homology to rat intestinal development protein OCI-5."
      Lage H. , Dietel M.
      Gene188:151-156(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    4. 4.
      "Expression of the Glypican-3 protein in hepatoma cells."
      Grozdanov P.N. , Yovchev M.I. , Dabeva M.D.
      Submitted (2006-01) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 3);VARIANT MET-429
    5. 5.
      "The DNA sequence of the human X chromosome."
      Ross M.T. , Grafham D.V. , Coffey A.J. , Scherer S. , McLay K. , Muzny D. , Platzer M. , Howell G.R. , Burrows C. , Bird C.P. , Frankish A. , Lovell F.L. , Howe K.L. , Ashurst J.L. , Fulton R.S. , Sudbrak R. , Wen G. , Jones M.C. , more...
      Nature434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      "Analysis of exon/intron structure and 400 kb of genomic sequence surrounding the 5'-promoter and 3'-terminal ends of the human glypican 3 (GPC3) gene."
      Huber R. , Crisponi L. , Mazzarella R. , Chen C.N. , Su Y. , Shizuya H. , Chen E.Y. , Cao A. , Pilia G.
      Genomics45:48-58(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-58
    8. 8.
      "The Simpson-Golabi-Behmel syndrome causative glypican-3, binds to and inhibits the dipeptidyl peptidase activity of CD26."
      Davoodi J. , Kelly J. , Gendron N.H. , MacKenzie A.E.
      Proteomics7:2300-2310(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH DPP4
    9. 9.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    10. 10.
      "Mutational analysis of the GPC3/GPC4 glypican gene cluster on Xq26 in patients with Simpson-Golabi-Behmel syndrome: identification of loss-of-function mutations in the GPC3 gene."
      Veugelers M. , Cat B.D. , Muyldermans S.Y. , Reekmans G. , Delande N. , Frints S. , Legius E. , Fryns J.-P. , Schrander-Stumpel C. , Weidle B. , Magdalena N. , David G.
      Hum. Mol. Genet.9:1321-1328(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT SGBS1 ARG-296
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