Protein name:
Kinase suppressor of Ras 2 (hKSR2) ;
Alternative:
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts with MAP2K1, MAP3K8, MAPK, RAS and RAF.
Function:
Location-regulated scaffold connecting MEK to RAF. Blocks MAP3K8 kinase activity and MAP3K8-mediated signaling. Acts as a negative regulator of MAP3K3-mediated activation of ERK, JNK and NF-kappa-B pathways, inhibiting MAP3K3-mediated interleukin-8 production.
Subcellular Location:
Cytoplasm
Membrane
Peripheral membrane protein
Protein Attributes:
50:
MDEENMTKSE | EQQPLSLQKA | LQQCELVQNM | IDLSISNLEG | LRTKCATSND |
100:
LTQKEIRTLE | SKLVKYFSRQ | LSCKKKVALQ | ERNAELDGFP | QLRHWFRIVD |
150:
VRKEVLEEIS | PGQLSLEDLL | EMTDEQVCET | VEKYGANREE | CARLNASLSC |
200:
LRNVHMSGGN | LSKQDWTIQW | PTTETGKENN | PVCPPEPTPW | IRTHLSQSPR |
250:
VPSKCVQHYC | HTSPTPGAPV | YTHVDRLTVD | AYPGLCPPPP | LESGHRSLPP |
300:
SPRQRHAVRT | PPRTPNIVTT | VTPPGTPPMR | KKNKLKPPGT | PPPSSRKLIH |
350:
LIPGFTALHR | SKSHEFQLGH | RVDEAHTPKA | KKKSKPLNLK | IHSSVGSCEN |
400:
IPSQQRSPLL | SERSLRSFFV | GHAPFLPSTP | PVHTEANFSA | NTLSVPRWSP |
450:
QIPRRDLGNS | IKHRFSTKYW | MSQTCTVCGK | GMLFGLKCKN | CKLKCHNKCT |
500:
KEAPPCHLLI | IHRGDPARLV | RTESVPCDIN | NPLRKPPRYS | DLHISQTLPK |
550:
TNKINKDHIP | VPYQPDSSSN | PSSTTSSTPS | SPAPPLPPSA | TPPSPLHPSP |
600:
QCTRQQKNFN | LPASHYYKYK | QQFIFPDVVP | VPETPTRAPQ | VILHPVTSNP |
650:
ILEGNPLLQI | EVEPTSENEE | VHDEAEESED | DFEEMNLSLL | SARSFPRKAS |
700:
QTSIFLQEWD | IPFEQLEIGE | LIGKGRFGQV | YHGRWHGEVA | IRLIDIERDN |
750:
EDQLKAFKRE | VMAYRQTRHE | NVVLFMGACM | SPPHLAIITS | LCKGRTLYSV |
800:
VRDAKIVLDV | NKTRQIAQEI | VKGMGYLHAK | GILHKDLKSK | NVFYDNGKVV |
850:
ITDFGLFSIS | GVLQAGRRED | KLRIQNGWLC | HLAPEIIRQL | SPDTEEDKLP |
900:
FSKHSDVFAL | GTIWYELHAR | EWPFKTQPAE | AIIWQMGTGM | KPNLSQIGMG |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Human
ELISA Kit for Human hKSR2
ELISA Kit for Human hKSR2
Polyclonal Antibody for Human hKSR2
Polyclonal Antibody for Human hKSR2
Monoclonal Antibody for Human hKSR2
Monoclonal Antibody for Human hKSR2
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T.
,
Suzuki Y.
,
Nishikawa T.
,
Otsuki T.
,
Sugiyama T.
,
Irie R.
,
Wakamatsu A.
,
Hayashi K.
,
Sato H.
,
Nagai K.
,
Kimura K.
,
Makita H.
,
Sekine M.
,
Obayashi M.
,
Nishi T.
,
Shibahara T.
,
Tanaka T.
,
Ishii S.
,
Yamamoto J.
,
Saito K.
,
Kawai Y.
,
Isono Y.
,
Nakamura Y.
,
Nagahari K.
,
Murakami K.
,
Yasuda T.
,
Iwayanagi T.
,
Wagatsuma M.
,
Shiratori A.
,
Sudo H.
,
Hosoiri T.
,
Kaku Y.
,
Kodaira H.
,
Kondo H.
,
Sugawara M.
,
Takahashi M.
,
Kanda K.
,
Yokoi T.
,
Furuya T.
,
Kikkawa E.
,
Omura Y.
,
Abe K.
,
Kamihara K.
,
Katsuta N.
,
Sato K.
,
Tanikawa M.
,
Yamazaki M.
,
Ninomiya K.
,
Ishibashi T.
,
Yamashita H.
,
Murakawa K.
,
Fujimori K.
,
Tanai H.
,
Kimata M.
,
Watanabe M.
,
Hiraoka S.
,
Chiba Y.
,
Ishida S.
,
Ono Y.
,
Takiguchi S.
,
Watanabe S.
,
Yosida M.
,
Hotuta T.
,
Kusano J.
,
Kanehori K.
,
Takahashi-Fujii A.
,
Hara H.
,
Tanase T.-O.
,
Nomura Y.
,
Togiya S.
,
Komai F.
,
Hara R.
,
Takeuchi K.
,
Arita M.
,
Imose N.
,
Musashino K.
,
Yuuki H.
,
Oshima A.
,
Sasaki N.
,
Aotsuka S.
,
Yoshikawa Y.
,
Matsunawa H.
,
Ichihara T.
,
Shiohata N.
,
Sano S.
,
Moriya S.
,
Momiyama H.
,
Satoh N.
,
Takami S.
,
Terashima Y.
,
Suzuki O.
,
Nakagawa S.
,
Senoh A.
,
Mizoguchi H.
,
Goto Y.
,
Shimizu F.
,
Wakebe H.
,
Hishigaki H.
,
Watanabe T.
,
Sugiyama A.
,
Takemoto M.
,
Kawakami B.
,
Yamazaki M.
,
Watanabe K.
,
Kumagai A.
,
Itakura S.
,
Fukuzumi Y.
,
Fujimori Y.
,
Komiyama M.
,
Tashiro H.
,
Tanigami A.
,
Fujiwara T.
,
Ono T.
,
Yamada K.
,
Fujii Y.
,
Ozaki K.
,
Hirao M.
,
Ohmori Y.
,
Kawabata A.
,
Hikiji T.
,
Kobatake N.
,
Inagaki H.
,
Ikema Y.
,
Okamoto S.
,
Okitani R.
,
Kawakami T.
,
Noguchi S.
,
Itoh T.
,
Shigeta K.
,
Senba T.
,
Matsumura K.
,
Nakajima Y.
,
Mizuno T.
,
Morinaga M.
,
Sasaki M.
,
Togashi T.
,
Oyama M.
,
Hata H.
,
Watanabe M.
,
Komatsu T.
,
Mizushima-Sugano J.
,
Satoh T.
,
Shirai Y.
,
Takahashi Y.
,
Nakagawa K.
,
Okumura K.
,
Nagase T.
,
Nomura N.
,
Kikuchi H.
,
Masuho Y.
,
Yamashita R.
,
Nakai K.
,
Yada T.
,
Nakamura Y.
,
Ohara O.
,
Isogai T.
,
Sugano S.
more...
Nat. Genet.36:40-45(2004)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
tissue :
Testis .
2.
"The finished DNA sequence of human chromosome 12."
Scherer S.E.
,
Muzny D.M.
,
Buhay C.J.
,
Chen R.
,
Cree A.
,
Ding Y.
,
Dugan-Rocha S.
,
Gill R.
,
Gunaratne P.
,
Harris R.A.
,
Hawes A.C.
,
Hernandez J.
,
Hodgson A.V.
,
Hume J.
,
Jackson A.
,
Khan Z.M.
,
Kovar-Smith C.
,
Lewis L.R.
,
Lozado R.J.
,
Metzker M.L.
,
Milosavljevic A.
,
Miner G.R.
,
Montgomery K.T.
,
Morgan M.B.
,
Nazareth L.V.
,
Scott G.
,
Sodergren E.
,
Song X.-Z.
,
Steffen D.
,
Lovering R.C.
,
Wheeler D.A.
,
Worley K.C.
,
Yuan Y.
,
Zhang Z.
,
Adams C.Q.
,
Ansari-Lari M.A.
,
Ayele M.
,
Brown M.J.
,
Chen G.
,
Chen Z.
,
Clerc-Blankenburg K.P.
,
Davis C.
,
Delgado O.
,
Dinh H.H.
,
Draper H.
,
Gonzalez-Garay M.L.
,
Havlak P.
,
Jackson L.R.
,
Jacob L.S.
,
Kelly S.H.
,
Li L.
,
Li Z.
,
Liu J.
,
Liu W.
,
Lu J.
,
Maheshwari M.
,
Nguyen B.-V.
,
Okwuonu G.O.
,
Pasternak S.
,
Perez L.M.
,
Plopper F.J.H.
,
Santibanez J.
,
Shen H.
,
Tabor P.E.
,
Verduzco D.
,
Waldron L.
,
Wang Q.
,
Williams G.A.
,
Zhang J.
,
Zhou J.
,
Allen C.C.
,
Amin A.G.
,
Anyalebechi V.
,
Bailey M.
,
Barbaria J.A.
,
Bimage K.E.
,
Bryant N.P.
,
Burch P.E.
,
Burkett C.E.
,
Burrell K.L.
,
Calderon E.
,
Cardenas V.
,
Carter K.
,
Casias K.
,
Cavazos I.
,
Cavazos S.R.
,
Ceasar H.
,
Chacko J.
,
Chan S.N.
,
Chavez D.
,
Christopoulos C.
,
Chu J.
,
Cockrell R.
,
Cox C.D.
,
Dang M.
,
Dathorne S.R.
,
David R.
,
Davis C.M.
,
Davy-Carroll L.
,
Deshazo D.R.
,
Donlin J.E.
,
D'Souza L.
,
Eaves K.A.
,
Egan A.
,
Emery-Cohen A.J.
,
Escotto M.
,
Flagg N.
,
Forbes L.D.
,
Gabisi A.M.
,
Garza M.
,
Hamilton C.
,
Henderson N.
,
Hernandez O.
,
Hines S.
,
Hogues M.E.
,
Huang M.
,
Idlebird D.G.
,
Johnson R.
,
Jolivet A.
,
Jones S.
,
Kagan R.
,
King L.M.
,
Leal B.
,
Lebow H.
,
Lee S.
,
LeVan J.M.
,
Lewis L.C.
,
London P.
,
Lorensuhewa L.M.
,
Loulseged H.
,
Lovett D.A.
,
Lucier A.
,
Lucier R.L.
,
Ma J.
,
Madu R.C.
,
Mapua P.
,
Martindale A.D.
,
Martinez E.
,
Massey E.
,
Mawhiney S.
,
Meador M.G.
,
Mendez S.
,
Mercado C.
,
Mercado I.C.
,
Merritt C.E.
,
Miner Z.L.
,
Minja E.
,
Mitchell T.
,
Mohabbat F.
,
Mohabbat K.
,
Montgomery B.
,
Moore N.
,
Morris S.
,
Munidasa M.
,
Ngo R.N.
,
Nguyen N.B.
,
Nickerson E.
,
Nwaokelemeh O.O.
,
Nwokenkwo S.
,
Obregon M.
,
Oguh M.
,
Oragunye N.
,
Oviedo R.J.
,
Parish B.J.
,
Parker D.N.
,
Parrish J.
,
Parks K.L.
,
Paul H.A.
,
Payton B.A.
,
Perez A.
,
Perrin W.
,
Pickens A.
,
Primus E.L.
,
Pu L.-L.
,
Puazo M.
,
Quiles M.M.
,
Quiroz J.B.
,
Rabata D.
,
Reeves K.
,
Ruiz S.J.
,
Shao H.
,
Sisson I.
,
Sonaike T.
,
Sorelle R.P.
,
Sutton A.E.
,
Svatek A.F.
,
Svetz L.A.
,
Tamerisa K.S.
,
Taylor T.R.
,
Teague B.
,
Thomas N.
,
Thorn R.D.
,
Trejos Z.Y.
,
Trevino B.K.
,
Ukegbu O.N.
,
Urban J.B.
,
Vasquez L.I.
,
Vera V.A.
,
Villasana D.M.
,
Wang L.
,
Ward-Moore S.
,
Warren J.T.
,
Wei X.
,
White F.
,
Williamson A.L.
,
Wleczyk R.
,
Wooden H.S.
,
Wooden S.H.
,
Yen J.
,
Yoon L.
,
Yoon V.
,
Zorrilla S.E.
,
Nelson D.
,
Kucherlapati R.
,
Weinstock G.
,
Gibbs R.A.
more...
Nature440:346-351(2006)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 122-950 (ISOFORM 1);FUNCTION;INTERACTION WITH MAP2K; RAS; RAF; MAPK AND MAP3K8;TISSUE SPECIFICITY
tissue :
Testis .
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 122-950 (ISOFORM 1)
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (3.46 ANGSTROMS) OF 634-950 OF MUTANT ALA-786 IN COMPLEX WITH ATP AND MAP2K1;FUNCTION;CATALYTIC ACTIVITY;ENZYME REGULATION;SUBUNIT;INTERACTION WITH BRAF AND MAP2K1;ACTIVE SITE;MUTAGENESIS OF ARG-718; ASP-786 AND ALA-879
7.
"Patterns of somatic mutation in human cancer genomes."
Greenman C.
,
Stephens P.
,
Smith R.
,
Dalgliesh G.L.
,
Hunter C.
,
Bignell G.
,
Davies H.
,
Teague J.
,
Butler A.
,
Stevens C.
,
Edkins S.
,
O'Meara S.
,
Vastrik I.
,
Schmidt E.E.
,
Avis T.
,
Barthorpe S.
,
Bhamra G.
,
Buck G.
,
Choudhury B.
,
Clements J.
,
Cole J.
,
Dicks E.
,
Forbes S.
,
Gray K.
,
Halliday K.
,
Harrison R.
,
Hills K.
,
Hinton J.
,
Jenkinson A.
,
Jones D.
,
Menzies A.
,
Mironenko T.
,
Perry J.
,
Raine K.
,
Richardson D.
,
Shepherd R.
,
Small A.
,
Tofts C.
,
Varian J.
,
Webb T.
,
West S.
,
Widaa S.
,
Yates A.
,
Cahill D.P.
,
Louis D.N.
,
Goldstraw P.
,
Nicholson A.G.
,
Brasseur F.
,
Looijenga L.
,
Weber B.L.
,
Chiew Y.-E.
,
DeFazio A.
,
Greaves M.F.
,
Green A.R.
,
Campbell P.
,
Birney E.
,
Easton D.F.
,
Chenevix-Trench G.
,
Tan M.-H.
,
Khoo S.K.
,
Teh B.T.
,
Yuen S.T.
,
Leung S.Y.
,
Wooster R.
,
Futreal P.A.
,
Stratton M.R.
more...
Nature446:153-158(2007)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT [LARGE SCALE ANALYSIS] SER-676