Enpp2 Polyclonal Antibody for Rat(Rattus norvegicus) | EIAab.comEnpp2 Polyclonal Antibody for Rat(Rattus norvegicus)

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Enpp2 (Gene name),

Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 (Protein name ), ENPP2_RAT from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Enpp2(Atx;Npps2);

Protein name:

Ectonucleotide pyrophosphatase/phosphodiesterase family member 2(E-NPP 2);

Alternative:

Extracellular lysophospholipase D(LysoPLD);Autotaxin;

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

N/A

Function:

Hydrolyzes lysophospholipids to produce lysophosphatidic acid (LPA) in extracellular fluids. Major substrate is lysophosphatidylcholine. Also can act on sphingosylphosphphorylcholine producing sphingosine-1-phosphate, a modulator of cell motility. Can hydrolyze, in vitro, bis-pNPP, to some extent pNP-TMP, and barely ATP. Involved in several motility-related processes such as angiogenesis and neurite outgrowth. Acts as an angiogenic factor by stimulating migration of smooth muscle cells and microtubule formation. Stimulates migration of melanoma cells, probably via a pertussis toxin-sensitive G protein. May have a role in induction of parturition. Possible involvement in cell proliferation and adipose tissue development. Tumor cell motility-stimulating factor.

Subcellular Location:

Secreted Secreted by most body fluids including serum and CSF. Also by adipocytes and numerous cancer cells.

Protein Attributes:

Sequence length:

887

Sequence:

50:

100:

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650:

700:

750:

800:

850:

887:

VRDIEHLTGL | DFYRKTSRSY | SEILTLKTYL | HTYESEI

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

STRING:

10116.ENSRNOP00000047118

Pfam:

PF01223

UniGene:

Rn.20403

KEGG:

rno:84050

String:

Q64610

Uniprot:

Q64610

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ELISA Kit for Rat E-NPP 2

Cat.:

E1228m

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96T

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ELISA Kit for Rat E-NPP 2

Cat.:

E1228h

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96T

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ELISA Kit for Rat E-NPP 2

Cat.:

E1228b

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96T

ELISA Kit for Rat E-NPP 2

Cat.:

E1228r

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Packing:

96T

CLIA Kit for Rat E-NPP 2

Cat.:

U1228b

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Packing:

96T

CLIA Kit for Rat E-NPP 2

Cat.:

U1228r

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Packing:

96T

CLIA Kit for Rat E-NPP 2

Cat.:

U1228h

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Manual:

Looking for manual.

MSDS:

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Packing:

96T

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CLIA Kit for Rat E-NPP 2

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U1228m

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Polyclonal Antibody for Rat E-NPP 2

Cat.:

P1228Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Rat E-NPP 2

Cat.:

P1228Rb-m

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40ug/0.2ml

Polyclonal Antibody for Rat E-NPP 2

Cat.:

P1228Rb-r

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Packing:

40ug/0.2ml

Polyclonal Antibody for Rat E-NPP 2

Monoclonal Antibody for Rat E-NPP 2

Protein for Rat E-NPP 2

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

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References

1.

"Molecular cloning, expression, and localization of a brain-specific phosphodiesterase I/nucleotide pyrophosphatase (PD-Ialpha) from rat brain."
Narita M. , Goji J. , Nakamura H. , Sano K.
J. Biol. Chem.269:28235-28242(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);TISSUE SPECIFICITY
strain: Sprague-Dawley.
tissue: Brain.
2.

"The N-terminal hydrophobic sequence of autotaxin (ENPP2) functions as a signal peptide."
Koike S. , Keino-Masu K. , Ohto T. , Masu M.
Genes Cells11:133-142(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);PROTEIN SEQUENCE OF 28-32 AND 36-41;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
strain: Sprague-Dawley.
3.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
4.

"Autotaxin has lysophospholipase D activity leading to tumor cell growth and motility by lysophosphatidic acid production."
Umezu-Goto M. , Kishi Y. , Taira A. , Hama K. , Dohmae N. , Takio K. , Yamori T. , Mills G.B. , Inoue K. , Aoki J. , Arai H.
J. Cell Biol.158:227-233(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
5.

"The hydrolysis of lysophospholipids and nucleotides by autotaxin (NPP2) involves a single catalytic site."
Gijsbers R. , Aoki J. , Arai H. , Bollen M.
FEBS Lett.538:60-64(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION;SUBCELLULAR LOCATION;MUTAGENESIS OF ASP-171; THR-209; ASP-311 AND HIS-315
6.

"Proteolytic maturation and activation of autotaxin (NPP2), a secreted metastasis-enhancing lysophospholipase D."
Jansen S. , Stefan C. , Creemers J.W. , Waelkens E. , Van Eynde A. , Stalmans W. , Bollen M.
J. Cell Sci.118:3081-3089(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEOLYTIC PROCESSING;PROTEIN SEQUENCE OF N-TERMINUS;FUNCTION CHARACTERIZATION;SUBCELLULAR LOCATION;MUTAGENESIS OF ILE-13; 16-PHE--PHE-18; 18-PHE--SER-21; 21-SER--ILE-24; 24-ILE--CYS-25 AND 28-PHE--ALA-30
7.

"Structural basis of substrate discrimination and integrin binding by autotaxin."
Hausmann J. , Kamtekar S. , Christodoulou E. , Day J.E. , Wu T. , Fulkerson Z. , Albers H.M. , van Meeteren L.A. , Houben A.J. , van Zeijl L. , Jansen S. , Andries M. , Hall T. , Pegg L.E. , Benson T.E. , Kasiem M. , Harlos K. , Kooi C.W. , more...
Nat. Struct. Mol. Biol.18:198-204(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.05 ANGSTROMS) OF 36-862 IN COMPLEX WITH INHIBITOR AND ZINC IONS;CATALYTIC ACTIVITY;COFACTOR;CALCIUM BINDING;DISULFIDE BONDS;GLYCOSYLATION AT ASN-524;ACTIVE SITE;MUTAGENESIS OF LYS-430 AND 764-ASP--ASP-768;SUBCELLULAR LOCATION

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