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Index > Protein center > Flnb(Gene name) > Mouse
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  • Flnb (Gene name),
  • Filamin-B (Protein name ),  FLNB_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Flnb;
    Protein name:
    Filamin-B(FLN-B);
    Alternative:
    Actin-binding-like protein;ABP-280-like protein;Beta-filamin;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Homodimer. Interacts with FLNA, FLNC, INPPL1, ITGB1A, ITGB1D, ITGB3, ITGB6, MYOT, MYOZ1, PSEN1 and PSEN2.
    Function:
    Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton.
    Subcellular Location:
    Cytoplasm cell cortex Cytoplasm myofibril sarcomere Z line Cytoplasm cytoskeleton May localize also at actin stress fibers and within the Z-lines.
    Protein Attributes:
    Sequence length:
    2602
    Sequence:
    50:
    MPVTEKDLAE | DAPWKKIQQN | TFTRWCNEHL | KCVNKRIGNL | QTDLSDGLRL | 
    100:
    IALLEVLSQK | RMHHKYHQRP | TFRQMKLENV | SVALEFLDHE | SIKLVSIDSK | 
    150:
    AIVDGNLKLI | LGLVWTLILH | YSISMPVWED | EGDDDAKKQT | PKQRLLGWIQ | 
    200:
    NKIPYLPITN | FNQNWQDGKA | LGALVDSCAP | GLCPDWESWD | PRKPVDNARE | 
    250:
    AMQQADDWLG | VPQVITPEEI | IHPDVDEHSV | MTYLSQFPKA | KLKPGAPLKP | 
    300:
    KLNPKKARAY | GRGIEPTGNM | VKQPAKFTVD | TISAGQGDVM | VFVEDPEGNK | 
    350:
    EEARVTPDSD | KNKTYSVEYL | PKVTGLHKVI | VLFAGQHISK | SPFEVNVDKA | 
    400:
    QGDASKVTAK | GPGLETTGNI | ANKPTYFDIY | TAGAGVGDIG | IEVEDPQGKN | 
    450:
    SVELLVEDRG | NQVYRCVYKP | VQPGPHVVKV | SFAGDAIPKS | PFGVQIGEAC | 
    500:
    NPNACRASGR | GLQPKGVRIR | ETADFKVDTK | AAGSGELGVT | VKGPKGLEEL | 
    550:
    VKQKGFLDGV | YSFEYYPSTP | GKYSVAVTWG | GHHIPKSPFE | VQVGPEAGMQ | 
    600:
    KVRAWGPGLH | GGIVGRSADF | VVESIGSEVG | TLGFAIEGPS | QAKIEYDDQN | 
    650:
    DGSCDVKYWP | KEPGEYAVHI | MCDDEDIKDS | PYMAFIHPAT | GDYNPDLVQA | 
    700:
    YGPGLEKSGC | TINNPAEFIV | DPKDAGSAPL | KILAQDGEGQ | PIDIQMKSRM | 
    750:
    DGTYACSYTP | LKAIKHTIAV | VWGGVNIPHS | PYRVNIGQGS | HPQKVKVFGP | 
    800:
    GVERSGLKAN | EPTHFTVDCT | EAGEGDVSVG | IKCDARVLSD | DEEDVDFDII | 
    850:
    HNANDTFTVK | YVPPAPGRYT | IKVLFASQEI | PASPFRVKVD | PSHDASKVKA | 
    900:
    EGPGLSKAGV | ENGKPTHFTV | HTKGAGKAPL | NVQFSSPLPG | EAVKDLDIID | 
    950:
    NYDYSHTVKY | TPTQQGNMQV | LVTYGGDPIP | KSPFTVGVAA | PLDLSKIKIN | 
    1000:
    GLENRVEVGK | DQEFAIDTNG | AGGQGKLDVT | ILSPSRKVVP | CLVAPVAGRE | 
    1050:
    CSTAKFIPRE | EGLFAVDVTY | DGHPVPGSPY | TVEASLPPDP | TKVKAHGPGL | 
    1100:
    EGGLVGKPAE | FTIDTKGAGT | GGLGLTVEGP | CEAKIECSDN | GDGTCSVSYL | 
    1150:
    PTKPGEYFVN | ILFEEVHIPG | SPFKADIEMP | FDPSKVVASG | PGLEHGKVGE | 
    1200:
    PGILCVDCSE | AGPGTLGLEA | VSDSGAKAEV | SIQNNKDGTY | AVTYVPLTAG | 
    1250:
    MYTLTMKYGG | ELVPHFPAWV | KVEPAIDTSG | IKAFGPGIEG | KDVFREATTD | 
    1300:
    FTVDSRPLTQ | VGGDHIKAQI | TNPSGASTEC | FVKDNADGTY | QVEYTPFEKG | 
    1350:
    FHVVEVTYDD | VPIPNSPFKV | AVTEGCQPSR | VHAQGPGLKE | AFTNKSNVFT | 
    1400:
    VVTRGAGIGG | LGITVEGPSE | SKINCRDNKD | GSCSAEYIPF | APGDYDVNIT | 
    1450:
    YGGVHIPGSP | FRVPSKDVVD | PSKVKIAGPG | LSSCVRACIP | QSFTVDSSKA | 
    1500:
    GLAPLEVRVL | GPRGLVEPVN | VVDNGDGTHT | VTYTPSQEGP | YIVSVKYADE | 
    1550:
    EIPRSPFKVK | VLPTYDASKV | TASGPGLSAY | GVPASLPVEF | AIDARDAGEG | 
    1600:
    LLAVQITDQE | GKPQRATVHD | NKDGTYAVTY | IPDKTGRYMI | GVTYGGDNIP | 
    1650:
    LSPYRIRATQ | TGDASKCLAT | GPGIAPTVKT | GEEVGFVVDA | KTAGKGKVTC | 
    1700:
    VILTPDGTEA | EADVIENEDG | TYDIFYTAAK | PGTYVIYVRF | GGVDIPNSPF | 
    1750:
    TVMATDGEVT | AMEEAPVNAC | PPGFRPWVTE | EAYVPVSDMN | GLGFKPFDLV | 
    1800:
    IPFAVRKGEI | TGTVHMPSGK | KATPEIVDNK | DGTVTVRYAP | TEVGLHEMHI | 
    1850:
    KYRGSHIPES | PLQFYVNYPN | SGSVSAYGPG | LVYGVANKTA | TFTIVTEDAG | 
    1900:
    EGGLDLAIEG | PSKAEISCID | NKDGTCTVTY | LPTLPGDYSI | LVKYNDKHIP | 
    1950:
    GSPFTAKITD | DNRRCSQVKL | GSAADFLLDI | SETDLSTLTA | SIKAPSGRDE | 
    2000:
    PCLLKRLPNN | HIGISFIPRE | VGEHLVSIKK | NGNHVANSPV | SIMVVQSEIG | 
    2050:
    DARRAKVYGQ | GLSEGRTFEM | SDFIVDTRDA | GYGGISLAVE | GPSKVDIQTE | 
    2100:
    DLEDGTCKVS | YFPTVPGVYI | VSTKFADEHV | PGSPFTVKIS | GEGRVRESIT | 
    2150:
    RTSRAPAVAT | VGSICDLNLK | IPEINSSDMS | AHVTSPSGHV | TEAEIVPMGK | 
    2200:
    NSHCVRFVPQ | EMGVHTVSVK | YRGQHVTGSP | FQFTVGPLGE | GGAHKVRAGG | 
    2250:
    PGLERGEAGI | PAEFSIWTRE | AGAGGLSIAV | EGPSKAEITF | DDHKNGSCGV | 
    2300:
    SYIAQEPGNY | EVSIKFNDEH | IPDSPYLVPV | IAPSDDARCL | TVLSLQESGL | 
    2350:
    KVNQPASFAI | RLNGAKGKID | AKVHSPSGAV | EECHVSELEP | DKYAVRFIPH | 
    2400:
    ENGIHTIDVK | FNGSHVVGSP | FKVRVGEPGQ | AGNPALVSAY | GAGLETGTTG | 
    2450:
    IQSEFFINTT | QAGPGTLSVT | IEGPSKVKMD | CQEIPEGYKV | MYTPMAPGNY | 
    2500:
    LIGVKYGGPN | HISRSPFKAK | VTGQRLVSPG | SANETSSILV | ESVTRSSTET | 
    2550:
    CYSAIPKSSS | DASKVTSKGA | GLSKAFVGQK | SSFLVDCSKA | GSNMLLIGVH | 
    2600:
    GPTTPCEEVS | MKHVGKQQYN | VTYVVKERGD | YVLAVKWGEE | HIPGSPFHVT | 
    2602:
    VP
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    UniGene:
    Pfam:
    UniGene:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse FLN-B
    Cat.:
    E11396h
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    Packing:
    96T
    Range:
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    ELISA Kit for Mouse FLN-B
    Cat.:
    E11396m
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Mouse FLN-B
    MSDS:
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    CLIA Kit for Mouse FLN-B
    MSDS:
    Please sign in first.
    CLIA Kit for Mouse FLN-B
    Cat.:
    U11396h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse FLN-B
    Cat.:
    U11396m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Mouse FLN-B
    Polyclonal Antibody for Mouse FLN-B
    Cat.:
    P11396Rb-h
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse FLN-B
    Monoclonal Antibody for Mouse FLN-B
    Monoclonal Antibody for Mouse FLN-B
    Monoclonal Antibody for Mouse FLN-B
    Protein for Mouse FLN-B
    Protein for Mouse FLN-B
    Protein for Mouse FLN-B

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
      strain: C57BL/6J.
    2. 2.
      "Different splice variants of filamin-B affect myogenesis, subcellular distribution, and determine binding to integrin (beta) subunits."
      van Der Flier A. , Kuikman I. , Kramer D. , Geerts D. , Kreft M. , Takafuta T. , Shapiro S.S. , Sonnenberg A.
      J. Cell Biol.156:361-376(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1663-1752 AND 2031-2181
      strain: C3H.
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1884-2602
      strain: FVB/N.
      tissue: Mammary tumor.
      tissue: Salivary gland.
    4. 4.
      "Filamin A and filamin B are co-expressed within neurons during periods of neuronal migration and can physically interact."
      Sheen V.L. , Feng Y. , Graham D. , Takafuta T. , Shapiro S.S. , Walsh C.A.
      Hum. Mol. Genet.11:2845-2854(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DEVELOPMENTAL STAGE;TISSUE SPECIFICITY
    5. 5.
      "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
      Rush J. , Moritz A. , Lee K.A. , Guo A. , Goss V.L. , Spek E.J. , Zhang H. , Zha X.-M. , Polakiewicz R.D. , Comb M.J.
      Nat. Biotechnol.23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    6. 6.
      "RefilinB (FAM101B) targets filamin A to organize perinuclear actin networks and regulates nuclear shape."
      Gay O. , Gilquin B. , Nakamura F. , Jenkins Z.A. , McCartney R. , Krakow D. , Deshiere A. , Assard N. , Hartwig J.H. , Robertson S.P. , Baudier J.
      Proc. Natl. Acad. Sci. U.S.A.108:11464-11469(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH FAM101A AND FAM101B
    7. 7.
      "Junctional Rab13-binding protein (JRAB) regulates cell spreading via filamins."
      Sakane A. , Alamir Mahmoud Abdallah A. , Nakano K. , Honda K. , Kitamura T. , Imoto I. , Matsushita N. , Sasaki T.
      Genes Cells18:810-822(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MICALL2
    8. 8.
      "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
      Park J. , Chen Y. , Tishkoff D.X. , Peng C. , Tan M. , Dai L. , Xie Z. , Zhang Y. , Zwaans B.M. , Skinner M.E. , Lombard D.B. , Zhao Y.
      Mol. Cell50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-1780;SUCCINYLATION [LARGE SCALE ANALYSIS] AT LYS-2518 AND LYS-2524;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Embryonic fibroblast.
    9. 9.
      "Filamin-interacting proteins, Cfm1 and Cfm2, are essential for the formation of cartilaginous skeletal elements."
      Mizuhashi K. , Kanamoto T. , Moriishi T. , Muranishi Y. , Miyazaki T. , Terada K. , Omori Y. , Ito M. , Komori T. , Furukawa T.
      Hum. Mol. Genet.23:2953-2967(2014) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH FAM101A AND FAM101B
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