TFCP2 Protein for Human(Homo sapiens) | EIAab.comTFCP2 Protein for Human(Homo sapiens) | EIAab.com

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TFCP2 (Gene name),

Alpha-globin transcription factor CP2 (Protein name ), TFCP2_HUMAN from NCBI database.

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General Annotation

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Antigen Annotation

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3D

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Predicted Eptitope

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Vaild Sequence

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Related Databases

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Gene name:

TFCP2(LSF;SEF);

Protein name:

Alpha-globin transcription factor CP2;

Alternative:

Transcription factor LSF;SAA3 enhancer factor;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Binds to DNA as a dimer, isoform 3 does not bind to DNA or affect the binding of isoform 1 to DNA. Interacts with UBP1 and PIAS1, and is probably part of a complex containing TFCP2, UBP1 and PIAS1 (By similarity). Component of the SSP (stage selector protein) complex, which appears to be a heteromer of TFCP2 and 2 copies of NFE4.

Function:

Binds a variety of cellular and viral promoters including fibrinogen, alpha-globin, SV40 and HIV-1 promoters. Activation of the alpha-globin promoter in erythroid cells is via synergistic interaction with UBP1 (By similarity). Functions as part of the SSP (stage selector protein) complex. Facilitates the interaction of the gamma-globin genes with enhancer elements contained in the locus control region in fetal erythroid cells. Interacts by binding to the stage selector element (SSE) in the proximal gamma-globin promoter.

Subcellular Location:

Nucleus

Protein Attributes:

Sequence length:

502

Sequence:

50:

MAWALKLPLA | DEVIESGLVQ | DFDASLSGIG | QELGAGAYSM | SDVLALPIFK |

100:

QEESSLPPDN | ENKILPFQYV | LCAATSPAVK | LHDETLTYLN | QGQSYEIRML |

150:

DNRKLGELPE | INGKLVKSIF | RVVFHDRRLQ | YTEHQQLEGW | RWNRPGDRIL |

200:

DIDIPMSVGI | IDPRANPTQL | NTVEFLWDPA | KRTSVFIQVH | CISTEFTMRK |

250:

HGGEKGVPFR | VQIDTFKENE | NGEYTEHLHS | ASCQIKVFKP | KGADRKQKTD |

300:

REKMEKRTPH | EKEKYQPSYE | TTILTECSPW | PEITYVNNSP | SPGFNSSHSS |

350:

FSLGEGNGSP | NHQPEPPPPV | TDNLLPTTTP | QEAQQWLHRN | RFSTFTRLFT |

400:

NFSGADLLKL | TRDDVIQICG | PADGIRLFNA | LKGRMVRPRL | TIYVCQESLQ |

450:

LREQQQQQQQ | QQQKHEDGDS | NGTFFVYHAI | YLEELTAVEL | TEKIAQLFSI |

500:

SPCQISQIYK | QGPTGIHVLI | SDEMIQNFQE | EACFILDTMK | AETNDSYHII |

502:

LK

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

Pfam:

String:

MIM:

SMR:

STRING:

9606.ENSP00000257915

UniGene:

Uniprot:

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ELISA Kit for Human Alpha-globin transcription factor CP2

MSDS:

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ELISA Kit for Human Alpha-globin transcription factor CP2

Cat.:

E13038h

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Packing:

96T

Range:

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CLIA Kit for Human Alpha-globin transcription factor CP2

Cat.:

U13038h

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Manual:

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Packing:

96T

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CLIA Kit for Human Alpha-globin transcription factor CP2

MSDS:

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Polyclonal Antibody for Human Alpha-globin transcription factor CP2

Polyclonal Antibody for Human Alpha-globin transcription factor CP2

Monoclonal Antibody for Human Alpha-globin transcription factor CP2

Monoclonal Antibody for Human Alpha-globin transcription factor CP2

Protein for Human Alpha-globin transcription factor CP2

Protein for Human Alpha-globin transcription factor CP2

R&D Technical Data

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Precision

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Recovery

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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

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Linearity

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References

1.

"Molecular cloning of the alpha-globin transcription factor CP2."
Lim L.C. , Swendeman S.L. , Sheffery M.
Mol. Cell. Biol.12:828-835(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4);PROTEIN SEQUENCE OF 129-140; 165-176; 348-358 AND 390-397;FUNCTION;SUBCELLULAR LOCATION
2.

"Characterization of a family of related cellular transcription factors which can modulate human immunodeficiency virus type 1 transcription in vitro."
Yoon J.-B. , Li G. , Roeder R.G.
Mol. Cell. Biol.14:1776-1785(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);NUCLEOTIDE SEQUENCE [MRNA] OF 61-502 (ISOFORM 3);DNA-BINDING;SUBCELLULAR LOCATION;ALTERNATIVE SPLICING
3.

"One exon of the human LSF gene includes conserved regions involved in novel DNA-binding and dimerization motifs."
Shirra M.K. , Zhu Q. , Huang H.-C. , Pallas D. , Hansen U.
Mol. Cell. Biol.14:5076-5087(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2);PROTEIN SEQUENCE OF 7-21; 81-98; 149-164; 165-179; 348-359 AND 363-376;FUNCTION;ALTERNATIVE SPLICING;MUTAGENESIS OF VAL-211; ILE-213; GLN-234 AND LYS-236
4.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4)
tissue: Teratocarcinoma.
5.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Muscle.
7.

"Characterization of the genomic structure, chromosomal location, promoter, and development expression of the alpha-globin transcription factor CP2."
Swendeman S.L. , Spielholz C. , Jenkins N.A. , Gilbert D.J. , Copeland N.G. , Sheffery M.
J. Biol. Chem.269:11663-11671(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY;DEVELOPMENTAL STAGE
8.

"Hemoglobin switching in man and chicken is mediated by a heteromeric complex between the ubiquitous transcription factor CP2 and a developmentally specific protein."
Jane S.M. , Nienhuis A.W. , Cunningham J.M.
EMBO J.14:97-105(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN THE SSP COMPLEX;TISSUE SPECIFICITY;SUBCELLULAR LOCATION;DEVELOPMENTAL STAGE
9.

Jane S.M. , Nienhuis A.W. , Cunningham J.M.
EMBO J.15:854-855(1995)

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
10.

"Purification and characterization of the serum amyloid A3 enhancer factor."
Bing Z. , Reddy S.A. , Ren Y. , Qin J. , Liao W.S.-L.
J. Biol. Chem.274:24649-24656(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY
11.

"Induction of human fetal globin gene expression by a novel erythroid factor, NF-E4."
Zhou W. , Clouston D.R. , Wang X. , Cerruti L. , Cunningham J.M. , Jane S.M.
Mol. Cell. Biol.20:7662-7672(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NFE4
12.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]

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