Protein name:
Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI-associated protein 2;BAI1-associated protein 2) ;
Alternative:
Insulin receptor tyrosine kinase 53 kDa substrate ;Insulin receptor substrate protein of 53 kDa (IRSp53;Insulin receptor substrate p53) ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Homodimer. Interacts with CDC42 and RAC1 that have been activated by GTP binding. Binds DIAPH1. Interacts with ATN1, BAI1, EPS8, SHANK1, SHANK2, SHANK3, TIAM1, WASF1 and WASF2. Interacts with ENAH after recruitment of CDC42.
Function:
Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection.
Subcellular Location:
Cytoplasm
Membrane
Peripheral membrane protein
Cell projection
filopodium
Cell projection
ruffle
Cytoplasm
cytoskeleton
Detected throughout the cytoplasm in the absence of specific binding partners. Detected in filopodia and close to membrane ruffles. Recruited to actin pedestals that are formed upon infection by bacteria at bacterial attachment sites.
Protein Attributes:
50:
MSLSRSEEMH | RLTENVYKTI | MEQFNPSLRN | FIAMGKNYEK | ALAGVTFAAK |
100:
GYFDALVKMG | ELASESQGSK | ELGDVLFQMA | EVHRQIQNQL | EETLKSFHNE |
150:
LLTQLEQKVE | LDSRYLSAAL | KKYQTEQRSK | GDALDKCQAE | LKKLRKKSQG |
200:
SKNPQKYSDK | ELQYIDAISN | KQGELENYVS | DGYKTALTEE | RRRFCFLVEK |
250:
QCAVAKNSAA | YHSKGKELLA | QKLPLWQQAC | ADPNKIPDRA | VQLMQQMANS |
300:
NGSILPSALS | ASKSNLVISD | PIPGAKPLPV | PPELAPFVGR | MSAQENVPVM |
350:
NGVAGPDSED | YNPWADRKAA | QPKSLSPPQS | QSKLSDSYSN | TLPVRKSVTP |
400:
KNSYATTENK | TLPRSSSMAA | GLERNGRMRV | KAIFSHAAGD | NSTLLSFKEG |
450:
DLITLLVPEA | RDGWHYGESE | KTKMRGWFPF | SYTRVLDSDG | SDRLHMSLQQ |
500:
GKSSSTGNLL | DKDDLALPPP | DYGTSSRAFP | TQTAGTFKQR | PYSVAVPAFS |
535:
QGLDDYGARS | VSRNPFANVH | LKPTVTNDRS | APLLS
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Bovine
Rat
Human
Mouse
ELISA Kit for Mouse BAI-associated protein 2
ELISA Kit for Mouse BAI-associated protein 2
ELISA Kit for Mouse BAI-associated protein 2
ELISA Kit for Mouse BAI-associated protein 2
CLIA Kit for Mouse BAI-associated protein 2
CLIA Kit for Mouse BAI-associated protein 2
CLIA Kit for Mouse BAI-associated protein 2
CLIA Kit for Mouse BAI-associated protein 2
Polyclonal Antibody for Mouse BAI-associated protein 2
Polyclonal Antibody for Mouse BAI-associated protein 2
Polyclonal Antibody for Mouse BAI-associated protein 2
Polyclonal Antibody for Mouse BAI-associated protein 2
Monoclonal Antibody for Mouse BAI-associated protein 2
Monoclonal Antibody for Mouse BAI-associated protein 2
Monoclonal Antibody for Mouse BAI-associated protein 2
Monoclonal Antibody for Mouse BAI-associated protein 2
Protein for Mouse BAI-associated protein 2
Protein for Mouse BAI-associated protein 2
Protein for Mouse BAI-associated protein 2
Protein for Mouse BAI-associated protein 2
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 4)
strain :
C57BL/6J .
tissue :
Brain .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS 2 AND 4)
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more...
Science309:1559-1563(2005)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
strain :
C57BL/6J .
tissue :
Embryo .
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)
strain :
FVB/N .
tissue :
Mammary gland .
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH DIAPH1
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ALTERNATIVE SPLICING;TISSUE SPECIFICITY
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Brain .
9.
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Nat. Cell Biol.8:1337-1347(2006)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INTERACTION WITH EPS8
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Liver .