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Index > Protein center > Baiap2(Gene name) > Mouse
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  • Baiap2 (Gene name),
  • Brain-specific angiogenesis inhibitor 1-associated protein 2 (Protein name ),  BAIP2_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    Baiap2;
    Protein name:
    Brain-specific angiogenesis inhibitor 1-associated protein 2(BAI-associated protein 2;BAI1-associated protein 2);
    Alternative:
    Insulin receptor tyrosine kinase 53 kDa substrate;Insulin receptor substrate protein of 53 kDa(IRSp53;Insulin receptor substrate p53);
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Homodimer. Interacts with CDC42 and RAC1 that have been activated by GTP binding. Binds DIAPH1. Interacts with ATN1, BAI1, EPS8, SHANK1, SHANK2, SHANK3, TIAM1, WASF1 and WASF2. Interacts with ENAH after recruitment of CDC42.
    Function:
    Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection.
    Subcellular Location:
    Cytoplasm Membrane Peripheral membrane protein Cell projection filopodium Cell projection ruffle Cytoplasm cytoskeleton Detected throughout the cytoplasm in the absence of specific binding partners. Detected in filopodia and close to membrane ruffles. Recruited to actin pedestals that are formed upon infection by bacteria at bacterial attachment sites.
    Protein Attributes:
    Sequence length:
    535
    Sequence:
    50:
    MSLSRSEEMH | RLTENVYKTI | MEQFNPSLRN | FIAMGKNYEK | ALAGVTFAAK | 
    100:
    GYFDALVKMG | ELASESQGSK | ELGDVLFQMA | EVHRQIQNQL | EETLKSFHNE | 
    150:
    LLTQLEQKVE | LDSRYLSAAL | KKYQTEQRSK | GDALDKCQAE | LKKLRKKSQG | 
    200:
    SKNPQKYSDK | ELQYIDAISN | KQGELENYVS | DGYKTALTEE | RRRFCFLVEK | 
    250:
    QCAVAKNSAA | YHSKGKELLA | QKLPLWQQAC | ADPNKIPDRA | VQLMQQMANS | 
    300:
    NGSILPSALS | ASKSNLVISD | PIPGAKPLPV | PPELAPFVGR | MSAQENVPVM | 
    350:
    NGVAGPDSED | YNPWADRKAA | QPKSLSPPQS | QSKLSDSYSN | TLPVRKSVTP | 
    400:
    KNSYATTENK | TLPRSSSMAA | GLERNGRMRV | KAIFSHAAGD | NSTLLSFKEG | 
    450:
    DLITLLVPEA | RDGWHYGESE | KTKMRGWFPF | SYTRVLDSDG | SDRLHMSLQQ | 
    500:
    GKSSSTGNLL | DKDDLALPPP | DYGTSSRAFP | TQTAGTFKQR | PYSVAVPAFS | 
    535:
    QGLDDYGARS | VSRNPFANVH | LKPTVTNDRS | APLLS
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    SMR:
    String:
    UniGene:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse BAI-associated protein 2
    ELISA Kit for Mouse BAI-associated protein 2
    ELISA Kit for Mouse BAI-associated protein 2
    ELISA Kit for Mouse BAI-associated protein 2
    CLIA Kit for Mouse BAI-associated protein 2
    CLIA Kit for Mouse BAI-associated protein 2
    CLIA Kit for Mouse BAI-associated protein 2
    CLIA Kit for Mouse BAI-associated protein 2
    Polyclonal Antibody for Mouse BAI-associated protein 2
    Polyclonal Antibody for Mouse BAI-associated protein 2
    Polyclonal Antibody for Mouse BAI-associated protein 2
    Polyclonal Antibody for Mouse BAI-associated protein 2
    Monoclonal Antibody for Mouse BAI-associated protein 2
    Monoclonal Antibody for Mouse BAI-associated protein 2
    Monoclonal Antibody for Mouse BAI-associated protein 2
    Monoclonal Antibody for Mouse BAI-associated protein 2
    Protein for Mouse BAI-associated protein 2
    Protein for Mouse BAI-associated protein 2
    Protein for Mouse BAI-associated protein 2
    Protein for Mouse BAI-associated protein 2

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    Precision
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    References
    1. 1.
      "Insulin receptor substrate protein p53 localization in rats suggests mechanism for specific polyglutamine neurodegeneration."
      Thomas E.A. , Foye P.E. , Alvarez C.E. , Usui H. , Sutcliffe J.G.
      Neurosci. Lett.309:145-148(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 4)
      strain: C57BL/6J.
      tissue: Brain.
    2. 2.
      "Genomic structure and alternative splicing of the insulin receptor tyrosine kinase substrate of 53-kDa protein."
      Miyahara A. , Okumura-Oho Y. , Miyashita T. , Hoshika A. , Yamada M.
      J. Hum. Genet.48:410-414(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS 2 AND 4)
    3. 3.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      strain: C57BL/6J.
      tissue: Embryo.
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)
      strain: FVB/N.
      tissue: Mammary gland.
    5. 5.
      "Rho small G-protein-dependent binding of mDia to an Src homology 3 domain-containing IRSp53/BAIAP2."
      Fujiwara T. , Mammoto A. , Kim Y. , Takai Y.
      Biochem. Biophys. Res. Commun.271:626-629(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DIAPH1
    6. 6.
      "Novel isoform of insulin receptor substrate p53/p58 is generated by alternative splicing in the CRIB/SH3-binding region."
      Alvarez C.E. , Sutcliffe J.G. , Thomas E.A.
      J. Biol. Chem.277:24728-24734(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ALTERNATIVE SPLICING;TISSUE SPECIFICITY
    7. 7.
      "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
      Rush J. , Moritz A. , Lee K.A. , Guo A. , Goss V.L. , Spek E.J. , Zhang H. , Zha X.-M. , Polakiewicz R.D. , Comb M.J.
      Nat. Biotechnol.23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    8. 8.
      "Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
      Trinidad J.C. , Specht C.G. , Thalhammer A. , Schoepfer R. , Burlingame A.L.
      Mol. Cell. Proteomics5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Brain.
    9. 9.
      "Regulation of cell shape by Cdc42 is mediated by the synergic actin-bundling activity of the Eps8-IRSp53 complex."
      Disanza A. , Mantoani S. , Hertzog M. , Gerboth S. , Frittoli E. , Steffen A. , Berhoerster K. , Kreienkamp H.J. , Milanesi F. , Di Fiore P.P. , Ciliberto A. , Stradal T.E. , Scita G.
      Nat. Cell Biol.8:1337-1347(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH EPS8
    10. 10.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Liver.
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