Gene name:
BCAM (LU;MSK19) ;
Protein name:
Basal cell adhesion molecule ;
Alternative:
B-CAM cell surface glycoprotein ;Auberger B antigen ;Lutheran antigen ;F8/G253 antigen ;Lutheran blood group glycoprotein ;
CD:
CD239 ;
Organism:
Human (Homo sapiens).
General Annotation
Function:
Laminin alpha-5 receptor. May mediate intracellular signaling.
Subcellular Location:
Membrane
Single-pass type I membrane protein
Protein Attributes:
50:
MEPPDAPAQA | RGAPRLLLLA | VLLAAHPDAQ | AEVRLSVPPL | VEVMRGKSVI |
100:
LDCTPTGTHD | HYMLEWFLTD | RSGARPRLAS | AEMQGSELQV | TMHDTRGRSP |
150:
PYQLDSQGRL | VLAEAQVGDE | RDYVCVVRAG | AAGTAEATAR | LNVFAKPEAT |
200:
EVSPNKGTLS | VMEDSAQEIA | TCNSRNGNPA | PKITWYRNGQ | RLEVPVEMNP |
250:
EGYMTSRTVR | EASGLLSLTS | TLYLRLRKDD | RDASFHCAAH | YSLPEGRHGR |
300:
LDSPTFHLTL | HYPTEHVQFW | VGSPSTPAGW | VREGDTVQLL | CRGDGSPSPE |
350:
YTLFRLQDEQ | EEVLNVNLEG | NLTLEGVTRG | QSGTYGCRVE | DYDAADDVQL |
400:
SKTLELRVAY | LDPLELSEGK | VLSLPLNSSA | VVNCSVHGLP | TPALRWTKDS |
450:
TPLGDGPMLS | LSSITFDSNG | TYVCEASLPT | VPVLSRTQNF | TLLVQGSPEL |
500:
KTAEIEPKAD | GSWREGDEVT | LICSARGHPD | PKLSWSQLGG | SPAEPIPGRQ |
550:
GWVSSSLTLK | VTSALSRDGI | SCEASNPHGN | KRHVFHFGTV | SPQTSQAGVA |
600:
VMAVAVSVGL | LLLVVAVFYC | VRRKGGPCCR | QRREKGAPPP | GEPGLSHSGS |
628:
EQPEQTGLLM | GGASGGARGG | SGGFGDEC
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Rat
Bovine
ELISA Kit for Human Basal cell adhesion molecule
ELISA Kit for Human Basal cell adhesion molecule
ELISA Kit for Human Basal cell adhesion molecule
ELISA Kit for Human Basal cell adhesion molecule
CLIA Kit for Human Basal cell adhesion molecule
CLIA Kit for Human Basal cell adhesion molecule
CLIA Kit for Human Basal cell adhesion molecule
CLIA Kit for Human Basal cell adhesion molecule
Polyclonal Antibody for Human Basal cell adhesion molecule
Polyclonal Antibody for Human Basal cell adhesion molecule
Polyclonal Antibody for Human Basal cell adhesion molecule
Polyclonal Antibody for Human Basal cell adhesion molecule
Monoclonal Antibody for Human Basal cell adhesion molecule
Monoclonal Antibody for Human Basal cell adhesion molecule
Monoclonal Antibody for Human Basal cell adhesion molecule
Monoclonal Antibody for Human Basal cell adhesion molecule
Protein for Human Basal cell adhesion molecule
Protein for Human Basal cell adhesion molecule
Protein for Human Basal cell adhesion molecule
Protein for Human Basal cell adhesion molecule
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
"The Lutheran blood group glycoprotein, another member of the immunoglobulin superfamily, is widely expressed in human tissues and is developmentally regulated in human liver."
Parsons S.F.
,
Mallinson G.
,
Holmes C.H.
,
Houlihan J.M.
,
Simpson K.L.
,
Mawby W.J.
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Spurr N.K.
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Warne D.
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Barclay A.N.
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Anstee D.J.
Proc. Natl. Acad. Sci. U.S.A.92:5496-5500(1995)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA];PROTEIN SEQUENCE OF 32-67 AND 182-203;VARIANT ALA-539
tissue :
Placenta .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS HIS-77; ILE-196; LYS-204; HIS-282; ILE-381; GLN-451 AND LEU-581
3.
"The DNA sequence and biology of human chromosome 19."
Grimwood J.
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Gordon L.A.
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Olsen A.S.
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Terry A.
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Schmutz J.
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Lamerdin J.E.
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Hellsten U.
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Goodstein D.
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Couronne O.
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Tran-Gyamfi M.
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Aerts A.
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Altherr M.
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Black S.
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Cleland C.A.
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Copeland A.
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Denys M.
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Detter J.C.
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Escobar J.
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Flowers D.
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Garcia C.
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Georgescu A.M.
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Glavina T.
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Gomez M.
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Gonzales E.
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Groza M.
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Hammon N.
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Hawkins T.
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Haydu L.
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Ho I.
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Huang W.
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Israni S.
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Jett J.
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Kadner K.
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Kimball H.
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Kobayashi A.
,
Larionov V.
,
Leem S.-H.
,
Lopez F.
,
Lou Y.
,
Lowry S.
,
Malfatti S.
,
Martinez D.
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McCready P.M.
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Medina C.
,
Morgan J.
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Nelson K.
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Nolan M.
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Ovcharenko I.
,
Pitluck S.
,
Pollard M.
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Popkie A.P.
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Predki P.
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Quan G.
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Ramirez L.
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Rash S.
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Retterer J.
,
Rodriguez A.
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Rogers S.
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Salamov A.
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Salazar A.
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She X.
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Smith D.
,
Slezak T.
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Solovyev V.
,
Thayer N.
,
Tice H.
,
Tsai M.
,
Ustaszewska A.
,
Vo N.
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Wagner M.
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Wheeler J.
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Wu K.
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Xie G.
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Yang J.
,
Dubchak I.
,
Furey T.S.
,
DeJong P.
,
Dickson M.
,
Gordon D.
,
Eichler E.E.
,
Pennacchio L.A.
,
Richardson P.
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Stubbs L.
,
Rokhsar D.S.
,
Myers R.M.
,
Rubin E.M.
,
Lucas S.M.
more...
Nature428:529-535(2004)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
4.
Mural R.J.
,
Istrail S.
,
Sutton G.G.
,
Florea L.
,
Halpern A.L.
,
Mobarry C.M.
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Lippert R.
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Walenz B.
,
Shatkay H.
,
Dew I.
,
Miller J.R.
,
Flanigan M.J.
,
Edwards N.J.
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Bolanos R.
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Fasulo D.
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Halldorsson B.V.
,
Hannenhalli S.
,
Turner R.
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Yooseph S.
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Lu F.
,
Nusskern D.R.
,
Shue B.C.
,
Zheng X.H.
,
Zhong F.
,
Delcher A.L.
,
Huson D.H.
,
Kravitz S.A.
,
Mouchard L.
,
Reinert K.
,
Remington K.A.
,
Clark A.G.
,
Waterman M.S.
,
Eichler E.E.
,
Adams M.D.
,
Hunkapiller M.W.
,
Myers E.W.
,
Venter J.C.
more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Brain .
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 1-588;VARIANT ALA-539
7.
"Molecular basis of Lub(-) individual among Chinese blood donors in Shanghai area."
Wang C.
,
Li Q.
,
Guo Z.
,
Yang Y.
,
Zhu Z.
Submitted (2007-11) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 492-539;VARIANT ALA-539
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : LU(A)/LU(B) POLYMORPHISM
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : LU(A)/LU(B) POLYMORPHISM
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : GLYCOSYLATION AT ASN-439
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION AT SER-596; SER-598 AND SER-621;MUTAGENESIS OF SER-621
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-439
tissue :
Plasma .
14.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INVOLVEMENT IN THE LUTHERAN NULL PHENOTYPE
15.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
16.
"The Laminin 511/521-binding site on the Lutheran blood group glycoprotein is located at the flexible junction of Ig domains 2 and 3."
Mankelow T.J.
,
Burton N.
,
Stefansdottir F.O.
,
Spring F.A.
,
Parsons S.F.
,
Pedersen J.S.
,
Oliveira C.L.
,
Lammie D.
,
Wess T.
,
Mohandas N.
,
Chasis J.A.
,
Brady R.L.
,
Anstee D.J.
Blood110:3398-3406(2007)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF 32-262;LAMININ-ALPHA5 BINDING REGION;DISULFIDE BONDS