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Index > Protein center > BHLHE41(Gene name) > Human
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  • BHLHE41 (Gene name),
  • Class E basic helix-loop-helix protein 41 (Protein name ),  BHE41_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    BHLHE41(BHLHB3;DEC2;SHARP1);
    Protein name:
    Class E basic helix-loop-helix protein 41(bHLHe41);
    Alternative:
    Differentially expressed in chondrocytes protein 2(hDEC2);Class B basic helix-loop-helix protein 3(bHLHb3);Enhancer-of-split and hairy-related protein 1(SHARP-1);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homodimerize.
    Function:
    May be a transcriptional repressor that represses both basal and activated transcription.
    Subcellular Location:
    Nucleus
    Protein Attributes:
    Sequence length:
    482
    Sequence:
    50:
    MDEGIPHLQE | RQLLEHRDFI | GLDYSSLYMC | KPKRSMKRDD | TKDTYKLPHR | 
    100:
    LIEKKRRDRI | NECIAQLKDL | LPEHLKLTTL | GHLEKAVVLE | LTLKHLKALT | 
    150:
    ALTEQQHQKI | IALQNGERSL | KSPIQSDLDA | FHSGFQTCAK | EVLQYLSRFE | 
    200:
    SWTPREPRCV | QLINHLHAVA | TQFLPTPQLL | TQQVPLSKGT | GAPSAAGSAA | 
    250:
    APCLERAGQK | LEPLAYCVPV | IQRTQPSAEL | AAENDTDTDS | GYGGEAEARP | 
    300:
    DREKGKGAGA | SRVTIKQEPP | GEDSPAPKRM | KLDSRGGGSG | GGPGGGAAAA | 
    350:
    AAALLGPDPA | AAAALLRPDA | ALLSSLVAFG | GGGGAPFPQP | AAAAAPFCLP | 
    400:
    FCFLSPSAAA | AYVQPFLDKS | GLEKYLYPAA | AAAPFPLLYP | GIPAPAAAAA | 
    450:
    AAAAAAAAAA | AFPCLSSVLS | PPPEKAGAAA | ATLLPHEVAP | LGAPHPQHPH | 
    482:
    GRTHLPFAGP | REPGNPESSA | QEDPSQPGKE | AP
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    MIM:
    SMR:
    KEGG:
    Pfam:
    String:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Human bHLHe41
    ELISA Kit for Human bHLHe41
    CLIA Kit for Human bHLHe41
    CLIA Kit for Human bHLHe41
    Polyclonal Antibody for Human bHLHe41
    Polyclonal Antibody for Human bHLHe41
    Monoclonal Antibody for Human bHLHe41
    Monoclonal Antibody for Human bHLHe41
    Protein for Human bHLHe41
    Protein for Human bHLHe41

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Molecular cloning and characterization of DEC2, a new member of basic helix-loop-helix proteins."
      Fujimoto K. , Shen M. , Noshiro M. , Matsubara K. , Shingu S. , Honda K. , Yoshida E. , Suardita K. , Matsuda Y. , Kato Y.
      Biochem. Biophys. Res. Commun.280:164-171(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    2. 2.
      NHLBI resequencing and genotyping service (RS&G)
      Submitted (2006-09) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    3. 3.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 4.
      "The basic helix-loop-helix protein, SHARP-1, represses transcription by a histone deacetylase-dependent and histone deacetylase-independent mechanism."
      Garriga-Canut M. , Roopra A. , Buckley N.J.
      J. Biol. Chem.276:14821-14828(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    5. 5.
      "A novel autofeedback loop of Dec1 transcription involved in circadian rhythm regulation."
      Kawamoto T. , Noshiro M. , Sato F. , Maemura K. , Takeda N. , Nagai R. , Iwata T. , Fujimoto K. , Furukawa M. , Miyazaki K. , Honma S. , Honma K.I. , Kato Y.
      Biochem. Biophys. Res. Commun.313:117-124(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    6. 6.
      "DNA binding, but not interaction with Bmal1, is responsible for DEC1-mediated transcription regulation of the circadian gene mPer1."
      Li Y. , Song X. , Ma Y. , Liu J. , Yang D. , Yan B.
      Biochem. J.382:895-904(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;HETERODIMERIZATION WITH BHLHE40/DEC1
    7. 7.
      "Functional analysis of the basic helix-loop-helix transcription factor DEC1 in circadian regulation. Interaction with BMAL1."
      Sato F. , Kawamoto T. , Fujimoto K. , Noshiro M. , Honda K.K. , Honma S. , Honma K. , Kato Y.
      Eur. J. Biochem.271:4409-4419(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    8. 8.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    9. 9.
      "The basic helix-loop-helix proteins differentiated embryo chondrocyte (DEC) 1 and DEC2 function as corepressors of retinoid X receptors."
      Cho Y. , Noshiro M. , Choi M. , Morita K. , Kawamoto T. , Fujimoto K. , Kato Y. , Makishima M.
      Mol. Pharmacol.76:1360-1369(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH RXRA;MUTAGENESIS OF 70-LEU-LEU-71
    10. 10.
      "The transcriptional repressor DEC2 regulates sleep length in mammals."
      He Y. , Jones C.R. , Fujiki N. , Xu Y. , Guo B. , Holder J.L. Jr. , Rossner M.J. , Nishino S. , Fu Y.H.
      Science325:866-870(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ARG-384;ASSOCIATION OF VARIANT ARG-384 WITH SHORT SLEEP PHENOTYPE
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