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Index > Protein center > BLMH(Gene name) > Human
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  • BLMH (Gene name),
  • Bleomycin hydrolase (Protein name ),  BLMH_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    BLMH;
    Protein name:
    Bleomycin hydrolase(BH;BLM hydrolase;BMH);
    Alternative:

    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homohexamer.
    Function:
    The normal physiological role of BLM hydrolase is unknown, but it catalyzes the inactivation of the antitumor drug BLM (a glycopeptide) by hydrolyzing the carboxamide bond of its B-aminoalaninamide moiety thus protecting normal and malignant cells from BLM toxicity.
    Subcellular Location:
    Cytoplasm
    Protein Attributes:
    Sequence length:
    455
    Sequence:
    50:
    MSSSGLNSEK | VAALIQKLNS | DPQFVLAQNV | GTTHDLLDIC | LKRATVQRAQ | 
    100:
    HVFQHAVPQE | GKPITNQKSS | GRCWIFSCLN | VMRLPFMKKL | NIEEFEFSQS | 
    150:
    YLFFWDKVER | CYFFLSAFVD | TAQRKEPEDG | RLVQFLLMNP | ANDGGQWDML | 
    200:
    VNIVEKYGVI | PKKCFPESYT | TEATRRMNDI | LNHKMREFCI | RLRNLVHSGA | 
    250:
    TKGEISATQD | VMMEEIFRVV | CICLGNPPET | FTWEYRDKDK | NYQKIGPITP | 
    300:
    LEFYREHVKP | LFNMEDKICL | VNDPRPQHKY | NKLYTVEYLS | NMVGGRKTLY | 
    350:
    NNQPIDFLKK | MVAASIKDGE | AVWFGCDVGK | HFNSKLGLSD | MNLYDHELVF | 
    400:
    GVSLKNMNKA | ERLTFGESLM | THAMTFTAVS | EKDDQDGAFT | KWRVENSWGE | 
    450:
    DHGHKGYLCM | TDEWFSEYVY | EVVVDRKHVP | EEVLAVLEQE | PIILPAWDPM | 
    455:
    GALAE
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    KEGG:
    Pfam:
    String:
    SMR:
    UniGene:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human BH
    ELISA Kit for Human BH
    ELISA Kit for Human BH
    ELISA Kit for Human BH
    ELISA Kit for Human BH
    CLIA Kit for Human BH
    CLIA Kit for Human BH
    CLIA Kit for Human BH
    CLIA Kit for Human BH
    CLIA Kit for Human BH
    Polyclonal Antibody for Human BH
    Polyclonal Antibody for Human BH
    Polyclonal Antibody for Human BH
    Polyclonal Antibody for Human BH
    Polyclonal Antibody for Human BH
    Monoclonal Antibody for Human BH
    Monoclonal Antibody for Human BH
    Monoclonal Antibody for Human BH
    Monoclonal Antibody for Human BH
    Monoclonal Antibody for Human BH
    Protein for Human BH
    Protein for Human BH
    Protein for Human BH
    Protein for Human BH
    Protein for Human BH

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Cloning and expression analysis of human bleomycin hydrolase, a cysteine proteinase involved in chemotherapy resistance."
      Ferrando A.A. , Velasco G. , Campo E. , Lopez-Otin C.
      Cancer Res.56:1746-1750(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Brain.
    2. 2.
      "Human bleomycin hydrolase: molecular cloning, sequencing, functional expression, and enzymatic characterization."
      Broemme D. , Rossi A.B. , Smeekens S.P. , Anderson D.C. , Payan D.G.
      Biochemistry35:6706-6714(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];PARTIAL PROTEIN SEQUENCE;VARIANT VAL-443
      tissue: Lung.
    3. 3.
      "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
      Submitted (2004-10) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    4. 4.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Amygdala.
    5. 5.
      Totoki Y. , Toyoda A. , Takeda T. , Sakaki Y. , Tanaka A. , Yokoyama S.
      Submitted (2005-04) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Lymph.
    8. 8.
      "Full-insert sequence of mapped XREF EST."
      Barrow I.K.-P. , Boguski M.S. , Touchman J.W. , Spencer F.
      Submitted (1998-08) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 292-455;VARIANT VAL-443
    9. 9.
      "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C. , Kumar C. , Gnad F. , Nielsen M.L. , Rehman M. , Walther T.C. , Olsen J.V. , Mann M.
      Science325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-391;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    10. 10.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    11. 11.
      "Crystal structure of human bleomycin hydrolase, a self-compartmentalizing cysteine protease."
      O'Farrell P.A. , Gonzalez F. , Zheng W. , Johnston S.A. , Joshua-Tor L.
      Structure7:619-627(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS)
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