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Index > Protein center > CCNA1(Gene name) > Human
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  • CCNA1 (Gene name),
  • Cyclin-A1 (Protein name ),  CCNA1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    CCNA1;
    Protein name:
    Cyclin-A1;
    Alternative:

    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with the CDK2 and the CDC2 protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. Does not bind CDK4 and CDK5 (in vitro). The cyclin A1-CDK2 complex interacts with transcription factor E2F-1 and RB proteins. Found in a complex with CDK2, CABLES1 and CCNE1 (By similarity). Interacts with INCA1 and KLHDC9.
    Function:
    May be involved in the control of the cell cycle at the G1/S (start) and G2/M (mitosis) transitions. May primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells.
    Subcellular Location:
    Nucleus
    Protein Attributes:
    Sequence length:
    465
    Sequence:
    50:
    METGFPAIMY | PGSFIGGWGE | EYLSWEGPGL | PDFVFQQQPV | ESEAMHCSNP | 
    100:
    KSGVVLATVA | RGPDACQILT | RAPLGQDPPQ | RTVLGLLTAN | GQYRRTCGQG | 
    150:
    ITRIRCYSGS | ENAFPPAGKK | ALPDCGVQEP | PKQGFDIYMD | ELEQGDRDSC | 
    200:
    SVREGMAFED | VYEVDTGTLK | SDLHFLLDFN | TVSPMLVDSS | LLSQSEDISS | 
    250:
    LGTDVINVTE | YAEEIYQYLR | EAEIRHRPKA | HYMKKQPDIT | EGMRTILVDW | 
    300:
    LVEVGEEYKL | RAETLYLAVN | FLDRFLSCMS | VLRGKLQLVG | TAAMLLASKY | 
    350:
    EEIYPPEVDE | FVYITDDTYT | KRQLLKMEHL | LLKVLAFDLT | VPTTNQFLLQ | 
    400:
    YLRRQGVCVR | TENLAKYVAE | LSLLEADPFL | KYLPSLIAAA | AFCLANYTVN | 
    450:
    KHFWPETLAA | FTGYSLSEIV | PCLSELHKAY | LDIPHRPQQA | IREKYKASKY | 
    465:
    LCVSLMEPPA | VLLLQ
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    Pfam:
    String:
    SMR:
    MIM:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human Cyclin-A1
    Cat.:
    E10115h
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human Cyclin-A1
    Cat.:
    E10115r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Human Cyclin-A1
    Cat.:
    E10115m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Cyclin-A1
    Cat.:
    U10115r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Cyclin-A1
    Cat.:
    U10115h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Cyclin-A1
    Cat.:
    U10115m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Cyclin-A1
    Cat.:
    P10115Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Cyclin-A1
    Cat.:
    P10115Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Cyclin-A1
    Cat.:
    P10115Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Cyclin-A1
    Monoclonal Antibody for Human Cyclin-A1
    Monoclonal Antibody for Human Cyclin-A1
    Protein for Human Cyclin-A1
    Protein for Human Cyclin-A1
    Protein for Human Cyclin-A1

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Characterization of a second human cyclin A that is highly expressed in testis and in several leukemic cell lines."
      Yang R. , Morosetti R. , Koeffler H.P.
      Cancer Res.57:913-920(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Myeloid.
    2. 2.
      "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
      Submitted (2004-10) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
    3. 3.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)
      tissue: Testis.
    4. 4.
      "The DNA sequence and analysis of human chromosome 13."
      Dunham A. , Matthews L.H. , Burton J. , Ashurst J.L. , Howe K.L. , Ashcroft K.J. , Beare D.M. , Burford D.C. , Hunt S.E. , Griffiths-Jones S. , Jones M.C. , Keenan S.J. , Oliver K. , Scott C.E. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Andrews D.T. , more...
      Nature428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      tissue: Brain.
    7. 7.
      "The human testes cyclin A1 disrupts growth and DNA damage response of a yeast replication mutant."
      Perkins E.L. , Wood V.J. , Sterling J.F. , Hashem V.I. , Resnick M.A.
      Submitted (1997-06) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 55-465
      tissue: Testis.
    8. 8.
      "Functions of cyclin A1 in the cell cycle and its interactions with transcription factor E2F-1 and the Rb family of proteins."
      Yang R. , Mueller C. , Huynh V. , Fung Y.K. , Yee A.S. , Koeffler H.P.
      Mol. Cell. Biol.19:2400-2407(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    9. 9.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH INCA1 AND KLHDC9
    10. 10.
      "Deubiquitinase USP37 is activated by CDK2 to antagonize APC(CDH1) and promote S phase entry."
      Huang X. , Summers M.K. , Pham V. , Lill J.R. , Liu J. , Lee G. , Kirkpatrick D.S. , Jackson P.K. , Fang G. , Dixit V.M.
      Mol. Cell42:511-523(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION;DEUBIQUITINATION BY USP37
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