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Index > Protein center > SGMS1(Gene name) > Human
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  • SGMS1 (Gene name),
  • Phosphatidylcholine:ceramide cholinephosphotransferase 1 (Protein name ),  SMS1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    SGMS1(MOB;SMS1;TMEM23);
    Protein name:
    Phosphatidylcholine:ceramide cholinephosphotransferase 1;
    Alternative:
    Sphingomyelin synthase 1;Medulla oblongata-derived protein(Protein Mob);Transmembrane protein 23;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Bidirectional lipid cholinephosphotransferase capable of converting phosphatidylcholine (PC) and ceramide to sphingomyelin (SM) and diacylglycerol (DAG) and vice versa. Direction is dependent on the relative concentrations of DAG and ceramide as phosphocholine acceptors. Directly and specifically recognizes the choline head group on the substrate. Also requires two fatty chains on the choline-P donor molecule in order to be recognized efficiently as a substrate. Does not function strictly as a SM synthase. Suppresses BAX-mediated apoptosis and also prevents cell death in response to stimuli such as hydrogen peroxide, osmotic stress, elevated temperature and exogenously supplied sphingolipids. May protect against cell death by reversing the stress-inducible increase in levels of proapoptotic ceramide. Required for cell growth.
    Subcellular Location:
    Golgi apparatus membrane Multi-pass membrane protein
    Protein Attributes:
    Sequence length:
    419
    Sequence:
    50:
    MLSASTMKEV | VYWSPKKVAD | WLLENAMPEY | CEPLEHFTGQ | DLINLTQEDF | 
    100:
    KKPPLCRVSS | DNGQRLLDMI | ETLKMEHHLE | AHKNGHANGH | LNIGVDIPTP | 
    150:
    DGSFSIKIKP | NGMPNGYRKE | MIKIPMPELE | RSQYPMEWGK | TFLAFLYALS | 
    200:
    CFVLTTVMIS | VVHERVPPKE | VQPPLPDTFF | DHFNRVQWAF | SICEINGMIL | 
    250:
    VGLWLIQWLL | LKYKSIISRR | FFCIVGTLYL | YRCITMYVTT | LPVPGMHFNC | 
    300:
    SPKLFGDWEA | QLRRIMKLIA | GGGLSITGSH | NMCGDYLYSG | HTVMLTLTYL | 
    350:
    FIKEYSPRRL | WWYHWICWLL | SVVGIFCILL | AHDHYTVDVV | VAYYITTRLF | 
    400:
    WWYHTMANQQ | VLKEASQMNL | LARVWWYRPF | QYFEKNVQGI | VPRSYHWPFP | 
    419:
    WPVVHLSRQV | KYSRLVNDT
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    SMR:
    Pfam:
    Pfam:
    UniGene:
    String:
    MIM:
    Uniprot:
     
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    Polyclonal Antibody for Human Phosphatidylcholine:ceramide cholinephosphotransferase 1
    Polyclonal Antibody for Human Phosphatidylcholine:ceramide cholinephosphotransferase 1
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    Polyclonal Antibody for Human Phosphatidylcholine:ceramide cholinephosphotransferase 1
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    Polyclonal Antibody for Human Phosphatidylcholine:ceramide cholinephosphotransferase 1
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    Monoclonal Antibody for Human Phosphatidylcholine:ceramide cholinephosphotransferase 1
    Monoclonal Antibody for Human Phosphatidylcholine:ceramide cholinephosphotransferase 1
    Monoclonal Antibody for Human Phosphatidylcholine:ceramide cholinephosphotransferase 1
    Monoclonal Antibody for Human Phosphatidylcholine:ceramide cholinephosphotransferase 1
    Monoclonal Antibody for Human Phosphatidylcholine:ceramide cholinephosphotransferase 1
    Protein for Human Phosphatidylcholine:ceramide cholinephosphotransferase 1
    Protein for Human Phosphatidylcholine:ceramide cholinephosphotransferase 1
    Protein for Human Phosphatidylcholine:ceramide cholinephosphotransferase 1
    Protein for Human Phosphatidylcholine:ceramide cholinephosphotransferase 1
    Protein for Human Phosphatidylcholine:ceramide cholinephosphotransferase 1

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    References
    1. 1.
      "Expression cloning of a human cDNA restoring sphingomyelin synthesis and cell growth in sphingomyelin synthase-defective lymphoid cells."
      Yamaoka S. , Miyaji M. , Kitano T. , Umehara H. , Okazaki T.
      J. Biol. Chem.279:18688-18693(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    2. 2.
      "Complete cDNA sequence of a novel gene, human mob."
      Yuan H.F. , Wang X. , Wang D.M. , Li H.M. , Feng K. , Bai C.X. , Zhang R. , Chen L. , Li Y.H. , Gao Y.H. , Zhen M. , Yue W. , Xie C. , Xie X.Y. , Niu L.L. , Gao W.J. , Zhang J. , Cao H. , more...
      Submitted (2003-04) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Fetal liver.
    3. 3.
      "A new spermatogenesis-related gene."
      Zhao H. , Miao S.Y. , Zhang X.D. , Liang G. , Qiao Y. , Wang L.F.
      Submitted (2003-06) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Testis.
    4. 4.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Lung.
    5. 5.
      "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P. , Earthrowl M.E. , Grafham D.V. , Rubenfield M. , French L. , Steward C.A. , Sims S.K. , Jones M.C. , Searle S. , Scott C. , Howe K. , Hunt S.E. , Andrews T.D. , Gilbert J.G.R. , Swarbreck D. , Ashurst J.L. , Taylor A. , Battles J. , more...
      Nature429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Lymph.
    7. 7.
      "Human gene MOB: structure specification and aspects of transcriptional activity."
      Vladychenskaya I.P. , Dergunova L.V. , Dmitrieva V.G. , Limborska S.A.
      Gene338:257-265(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-296 (ISOFORM 2);IDENTIFICATION (ISOFORM 1);TISSUE SPECIFICITY
      tissue: Cerebellum.
    8. 8.
      "Structure and functional organization of a novel human brain-specific gene MOB encoding a phylogenetically conserved transmembrane protein."
      Vladychenskaya I.P. , Dergunova L.V. , Limborska S.A. , Dmitrieva V.G.
      Submitted (2003-06) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-283 (ISOFORM 1)
    9. 9.
      "In vitro and in silico analysis of the predicted human MOB gene encoding a phylogenetically conserved transmembrane protein."
      Vladychenskaya I.P. , Dergunova L.V. , Limborska S.A.
      Biomol. Eng.18:263-268(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION (ISOFORM 1);TISSUE SPECIFICITY
    10. 10.
      "Identification of a family of animal sphingomyelin synthases."
      Huitema K. , Van Den Dikkenberg J. , Brouwers J.F.H.M. , Holthuis J.C.
      EMBO J.23:33-44(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY;ENZYME REGULATION;TOPOLOGY OF C-TERMINUS
    11. 11.
      "Adenovirus-mediated overexpression of sphingomyelin synthases 1 and 2 increases the atherogenic potential in mice."
      Dong J. , Liu J. , Lou B. , Li Z. , Ye X. , Wu M. , Jiang X.-C.
      J. Lipid Res.47:1307-1314(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: OVEREXPRESSION IN MOUSE
    12. 12.
      "Both sphingomyelin synthases SMS1 and SMS2 are required for sphingomyelin homeostasis and growth in human HeLa cells."
      Tafesse F.G. , Huitema K. , Hermansson M. , van der Poel S. , van den Dikkenberg J. , Uphoff A. , Somerharju P. , Holthuis J.C.M.
      J. Biol. Chem.282:17537-17547(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
    13. 13.
      "The domain responsible for sphingomyelin synthase (SMS) activity."
      Yeang C. , Varshney S. , Wang R. , Zhang Y. , Ye D. , Jiang X.C.
      Biochim. Biophys. Acta1781:610-617(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACTIVE SITES;SUBCELLULAR LOCATION;MUTAGENESIS OF SER-289; HIS-291; HIS-334 AND ASP-338
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