Gene name:
SGMS1 (MOB;SMS1;TMEM23) ;
Protein name:
Phosphatidylcholine:ceramide cholinephosphotransferase 1 ;
Alternative:
Sphingomyelin synthase 1 ;Medulla oblongata-derived protein (Protein Mob) ;Transmembrane protein 23 ;
Organism:
Human (Homo sapiens).
General Annotation
Function:
Bidirectional lipid cholinephosphotransferase capable of converting phosphatidylcholine (PC) and ceramide to sphingomyelin (SM) and diacylglycerol (DAG) and vice versa. Direction is dependent on the relative concentrations of DAG and ceramide as phosphocholine acceptors. Directly and specifically recognizes the choline head group on the substrate. Also requires two fatty chains on the choline-P donor molecule in order to be recognized efficiently as a substrate. Does not function strictly as a SM synthase. Suppresses BAX-mediated apoptosis and also prevents cell death in response to stimuli such as hydrogen peroxide, osmotic stress, elevated temperature and exogenously supplied sphingolipids. May protect against cell death by reversing the stress-inducible increase in levels of proapoptotic ceramide. Required for cell growth.
Subcellular Location:
Golgi apparatus membrane
Multi-pass membrane protein
Protein Attributes:
50:
MLSASTMKEV | VYWSPKKVAD | WLLENAMPEY | CEPLEHFTGQ | DLINLTQEDF |
100:
KKPPLCRVSS | DNGQRLLDMI | ETLKMEHHLE | AHKNGHANGH | LNIGVDIPTP |
150:
DGSFSIKIKP | NGMPNGYRKE | MIKIPMPELE | RSQYPMEWGK | TFLAFLYALS |
200:
CFVLTTVMIS | VVHERVPPKE | VQPPLPDTFF | DHFNRVQWAF | SICEINGMIL |
250:
VGLWLIQWLL | LKYKSIISRR | FFCIVGTLYL | YRCITMYVTT | LPVPGMHFNC |
300:
SPKLFGDWEA | QLRRIMKLIA | GGGLSITGSH | NMCGDYLYSG | HTVMLTLTYL |
350:
FIKEYSPRRL | WWYHWICWLL | SVVGIFCILL | AHDHYTVDVV | VAYYITTRLF |
400:
WWYHTMANQQ | VLKEASQMNL | LARVWWYRPF | QYFEKNVQGI | VPRSYHWPFP |
419:
WPVVHLSRQV | KYSRLVNDT
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Rat
Human
Pig
Mouse
Chicken
ELISA Kit for Human Phosphatidylcholine:ceramide cholinephosphotransferase 1
ELISA Kit for Human Phosphatidylcholine:ceramide cholinephosphotransferase 1
ELISA Kit for Human Phosphatidylcholine:ceramide cholinephosphotransferase 1
ELISA Kit for Human Phosphatidylcholine:ceramide cholinephosphotransferase 1
ELISA Kit for Human Phosphatidylcholine:ceramide cholinephosphotransferase 1
CLIA Kit for Human Phosphatidylcholine:ceramide cholinephosphotransferase 1
CLIA Kit for Human Phosphatidylcholine:ceramide cholinephosphotransferase 1
CLIA Kit for Human Phosphatidylcholine:ceramide cholinephosphotransferase 1
CLIA Kit for Human Phosphatidylcholine:ceramide cholinephosphotransferase 1
CLIA Kit for Human Phosphatidylcholine:ceramide cholinephosphotransferase 1
Polyclonal Antibody for Human Phosphatidylcholine:ceramide cholinephosphotransferase 1
Polyclonal Antibody for Human Phosphatidylcholine:ceramide cholinephosphotransferase 1
Polyclonal Antibody for Human Phosphatidylcholine:ceramide cholinephosphotransferase 1
Polyclonal Antibody for Human Phosphatidylcholine:ceramide cholinephosphotransferase 1
Polyclonal Antibody for Human Phosphatidylcholine:ceramide cholinephosphotransferase 1
Monoclonal Antibody for Human Phosphatidylcholine:ceramide cholinephosphotransferase 1
Monoclonal Antibody for Human Phosphatidylcholine:ceramide cholinephosphotransferase 1
Monoclonal Antibody for Human Phosphatidylcholine:ceramide cholinephosphotransferase 1
Monoclonal Antibody for Human Phosphatidylcholine:ceramide cholinephosphotransferase 1
Monoclonal Antibody for Human Phosphatidylcholine:ceramide cholinephosphotransferase 1
Protein for Human Phosphatidylcholine:ceramide cholinephosphotransferase 1
Protein for Human Phosphatidylcholine:ceramide cholinephosphotransferase 1
Protein for Human Phosphatidylcholine:ceramide cholinephosphotransferase 1
Protein for Human Phosphatidylcholine:ceramide cholinephosphotransferase 1
Protein for Human Phosphatidylcholine:ceramide cholinephosphotransferase 1
R&D Technical Data
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Precision
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Recovery
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Linearity
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue :
Lung .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue :
Lymph .
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 1-296 (ISOFORM 2);IDENTIFICATION (ISOFORM 1);TISSUE SPECIFICITY
tissue :
Cerebellum .
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 1-283 (ISOFORM 1)
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION (ISOFORM 1);TISSUE SPECIFICITY
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY;ENZYME REGULATION;TOPOLOGY OF C-TERMINUS
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : OVEREXPRESSION IN MOUSE
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;SUBCELLULAR LOCATION
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ACTIVE SITES;SUBCELLULAR LOCATION;MUTAGENESIS OF SER-289; HIS-291; HIS-334 AND ASP-338