Protein name:
V-set domain containing T-cell activation inhibitor 1 ;
Alternative:
Protein B7S1 ;Immune costimulatory protein B7-H4 ;T cell costimulatory molecule B7x ;
Organism:
Mouse (Mus musculus).
General Annotation
Function:
Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. Involved in promoting epithelial cell transformation.
Subcellular Location:
Cell membrane
Lipid-anchor
GPI-anchor
Expressed at the cell surface. A soluble form has also been detected.
Protein Attributes:
50:
MASLGQIIFW | SIINIIIILA | GAIALIIGFG | ISGKHFITVT | TFTSAGNIGE |
100:
DGTLSCTFEP | DIKLNGIVIQ | WLKEGIKGLV | HEFKEGKDDL | SQQHEMFRGR |
150:
TAVFADQVVV | GNASLRLKNV | QLTDAGTYTC | YIRTSKGKGN | ANLEYKTGAF |
200:
SMPEINVDYN | ASSESLRCEA | PRWFPQPTVA | WASQVDQGAN | FSEVSNTSFE |
250:
LNSENVTMKV | VSVLYNVTIN | NTYSCMIEND | IAKATGDIKV | TDSEVKRRSQ |
283:
LQLLNSGPSP | CVFSSAFVAG | WALLSLSCCL | MLR
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Rat
ELISA Kit for Mouse V-set domain containing T-cell activation inhibitor 1
ELISA Kit for Mouse V-set domain containing T-cell activation inhibitor 1
ELISA Kit for Mouse V-set domain containing T-cell activation inhibitor 1
CLIA Kit for Mouse V-set domain containing T-cell activation inhibitor 1
CLIA Kit for Mouse V-set domain containing T-cell activation inhibitor 1
CLIA Kit for Mouse V-set domain containing T-cell activation inhibitor 1
Polyclonal Antibody for Mouse V-set domain containing T-cell activation inhibitor 1
Polyclonal Antibody for Mouse V-set domain containing T-cell activation inhibitor 1
Polyclonal Antibody for Mouse V-set domain containing T-cell activation inhibitor 1
Monoclonal Antibody for Mouse V-set domain containing T-cell activation inhibitor 1
Monoclonal Antibody for Mouse V-set domain containing T-cell activation inhibitor 1
Monoclonal Antibody for Mouse V-set domain containing T-cell activation inhibitor 1
Protein for Mouse V-set domain containing T-cell activation inhibitor 1
Protein for Mouse V-set domain containing T-cell activation inhibitor 1
Protein for Mouse V-set domain containing T-cell activation inhibitor 1
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
"B7-H4, a molecule of the B7 family, negatively regulates T cell immunity."
Sica G.L.
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Choi I.-H.
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Zhu G.
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Immunity18:849-861(2003)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
strain :
BALB/c .
tissue :
Spleen .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;TISSUE SPECIFICITY;INDUCTION;GPI-ANCHOR
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
strain :
FVB/N .
4.
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more...
Science309:1559-1563(2005)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain :
C57BL/6J .
tissue :
Blastocyst .
tissue :
Oviduct .
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Uterus .
6.
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Mak T.W.
Mol. Cell. Biol.26:6403-6411(2006)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : DISRUPTION PHENOTYPE