Protein name:
Cyclic nucleotide-gated cation channel beta-3 ;
Alternative:
Cyclic nucleotide-gated cation channel modulatory subunit ;Cone photoreceptor cGMP-gated channel subunit beta ;Cyclic nucleotide-gated channel subunit CNG6 ;Cyclic nucleotide-gated channel beta-3 (CNG channel beta-3) ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Heterooligomeric complex with CNGA3.
Function:
Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cGMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors. Essential for the generation of light-evoked electrical responses in the red-, green- and blue sensitive cones (By similarity). Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficacy of the channel when coexpressed with CNGA3.
Subcellular Location:
Membrane
Multi-pass membrane protein
Protein Attributes:
50:
MLKSLTVKFN | KVNPMEGRME | KKLCPNLSSL | SQPTIAQGDN | QSEKEPLRSR |
100:
TPITFEKSHS | KEDNSTGENS | LRDFTPNPDP | ECRAELTRTM | AEMEKTRTGK |
150:
ERPVSFKTKV | LETSIINEYT | DAHLHNLVER | MRERTALYKK | TLTEEENFPE |
200:
VEASSQTAMS | TNISPKQENN | SKLKEHQDTF | SFKPQRVPVK | EHLRRMILPR |
250:
SIDSYTDRVY | LLWLLLVTIA | YNWNCWLLPV | RLVFPCQTPD | NKNYWIITDI |
300:
VCDIIYLCDI | LLIQPRLQFV | RGGEIIVDSN | ELKRNYRSST | KFRMDVASLL |
350:
PFEVLYIFFG | VNPIFRANRI | LKYTSFFEFN | HHLESIMDKA | YVYRVIRTTG |
400:
YLLFLLHINA | CVYYWASDYE | GIGSTKWVYN | GEGNKYLRCF | YWAVRTLITI |
450:
GGLPEPQTSF | EIVFQFLNFF | SGVFVFSSLI | GQMRDVIGAA | TANQNYFQAC |
500:
MDHIIAYMNK | YSIPQSVQYR | VRTWLEYTWN | SQRILDESNL | LENLPTAMQL |
550:
SIALDINFSI | IDKVELFKGC | DTQMIYDLLL | RLKSTIYLPG | DFVCKKGEIG |
600:
KEMYIIKHGE | VQVLGGPDGA | QVLVTLKAGS | VFGEISLLAK | GGGNRRTADV |
650:
VAHGFANLLT | LDKKTLQEIL | LHYPTSKKLL | MKKAKILLSQ | KGKTTQAIPA |
694:
RPGPAFLFPP | KEETPRMLKV | LLGNTGKVDL | GRLLKGKRKT | TTQK
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Dog
Human
Mouse
ELISA Kit for Mouse Cyclic nucleotide-gated cation channel beta-3
ELISA Kit for Mouse Cyclic nucleotide-gated cation channel beta-3
ELISA Kit for Mouse Cyclic nucleotide-gated cation channel beta-3
CLIA Kit for Mouse Cyclic nucleotide-gated cation channel beta-3
CLIA Kit for Mouse Cyclic nucleotide-gated cation channel beta-3
CLIA Kit for Mouse Cyclic nucleotide-gated cation channel beta-3
Polyclonal Antibody for Mouse Cyclic nucleotide-gated cation channel beta-3
Polyclonal Antibody for Mouse Cyclic nucleotide-gated cation channel beta-3
Polyclonal Antibody for Mouse Cyclic nucleotide-gated cation channel beta-3
Monoclonal Antibody for Mouse Cyclic nucleotide-gated cation channel beta-3
Monoclonal Antibody for Mouse Cyclic nucleotide-gated cation channel beta-3
Monoclonal Antibody for Mouse Cyclic nucleotide-gated cation channel beta-3
Protein for Mouse Cyclic nucleotide-gated cation channel beta-3
Protein for Mouse Cyclic nucleotide-gated cation channel beta-3
Protein for Mouse Cyclic nucleotide-gated cation channel beta-3
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
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Cited for : NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;SUBUNIT;TISSUE SPECIFICITY
strain :
C57BL/6 .
tissue :
Retina .