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Index > Protein center > C3(Gene name) > Rat
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  • C3 (Gene name),
  • Complement C3 (Protein name ),  CO3_RAT from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    C3;
    Protein name:
    Complement C3;
    Alternative:

    Organism:
    Rat (Rattus norvegicus). 
    General Annotation
    Sub Unit:
    C3dg interacts with CR2 (via the N-terminal Sushi domains 1 and 2). Interacts with VSIG4 (By similarity). C3 precursor is first processed by the removal of 4 Arg residues, forming two chains, beta and alpha, linked by a disulfide bond. C3 convertase activates C3 by cleaving the alpha chain, releasing C3a anaphylatoxin and generating C3b (beta chain + alpha' chain).
    Function:
    Complement C3 alpha chain and neutrophil chemotactic factor-2 act as chemoattractants for neurophils.
    Subcellular Location:
    Secreted
    Protein Attributes:
    Sequence length:
    1663
    Sequence:
    50:
    MGPTSGSQLL | VLLLLLASSL | LALGSPMYSI | ITPNVLRLES | EETFILEAHD | 
    100:
    AQGDVPVTVT | VQDFLKKQVL | TSEKTVLTGA | TGHLNRVFIK | IPASKEFNAD | 
    150:
    KGHKYVTVVA | NFGATVVEKA | VLVSFQSGYL | FIQTDKTIYT | PGSTVFYRIF | 
    200:
    TVDNNLLPVG | KTVVIVIETP | DGVPIKRDIL | SSHNQYGILP | LSWNIPELVN | 
    250:
    MGQWKIRAFY | EHAPKQTFSA | EFEVKEYVLP | SFEVLVEPTE | KFYYIHGPKG | 
    300:
    LEVSITARFL | YGKNVDGTAF | VIFGVQDEDK | KISLALSLTR | VLIEDGSGEA | 
    350:
    VLSRKVLMDG | VRPSSPEALV | GKSLYVSVTV | ILHSGSDMVE | AERSGIPIVT | 
    400:
    SPYQIHFTKT | PKFFKPAMPF | DLMVFVTNPD | GSPARRVPVV | TQGSDAQALT | 
    450:
    QDDGVAKLSV | NTPNNRQPLT | ITVSTKKEGI | PDARQATRTM | QAQPYSTMHN | 
    500:
    SNNYLHLSVS | RVELKPGDNL | NVNFHLRTDA | GQEAKIRYYT | YLVMNKGKLL | 
    550:
    KAGRQVREPG | QDLVVLSLPI | TPEFIPSFRL | VAYYTLIGAN | GQREVVADSV | 
    600:
    WVDVKDSCVG | TLVVKGDPRD | NRQPAPGHQT | TLRIEGNQGA | RVGLVAVDKG | 
    650:
    VFVLNKKNKL | TQSKIWDVVE | KADIGCTPGS | GKNYAGVFMD | AGLTFKTNQG | 
    700:
    LQTDQREDPE | CAKPAARRRR | SVQLMERRMD | KAGQYTDKGL | RKCCEDGMRD | 
    750:
    IPMPYSCQRR | ARLITQGESC | LKAFMDCCNY | ITKLREQHRR | DHVLGLARSD | 
    800:
    VDEDIIPEED | IISRSHFPES | WLWTIEELKE | PEKNGISTKV | MNIFLKDSIT | 
    850:
    TWEILAVSLS | DKKGICVADP | YEITVMQDFF | IDLRLPYSVV | RNEQVEIRAV | 
    900:
    LFNYREQEKL | KVRVELLHNP | AFCSMATAKK | RYYQTIEIPP | KSSVAVPYVI | 
    950:
    VPLKIGLQEV | EVKAAVFNHF | ISDGVKKILK | VVPEGMRVNK | TVAVRTLDPE | 
    1000:
    HLNQGGVQRE | DVNAADLSDQ | VPDTDSETRI | LLQGTPVAQM | AEDAVDGERL | 
    1050:
    KHLIVTPSGC | GEQNMIGMTP | TVIAVHYLDQ | TEQWEKFGLE | KRQEALELIK | 
    1100:
    KGYTQQLAFK | QPISAYAAFN | NRPPSTWLTA | MWSRSFSLAA | NLIAIDSQVL | 
    1150:
    CGAVKWLILE | KQKPDGVFQE | DGPVIHQEMI | GGFRNTKEAD | VSLTAFVLIA | 
    1200:
    LQEARDICEG | QVNSLPGSIN | KAGEYLEASY | LNLQRPYTVA | IAGYALALMN | 
    1250:
    KLEEPYLTKF | LNTAKDRNRW | EEPGQQLYNV | EATSYALLAL | LLLKDFDSVP | 
    1300:
    PVVRWLNDER | YYGGGYGSTQ | ATFMVFQALA | QYRADVPDHK | DLNMDVSLHL | 
    1350:
    PSRSSPTVFR | LLWESGSLLR | SEETKQNEGF | SLTAKGKGQG | TLSVVTVYHA | 
    1400:
    KVKGKTTCKK | FDLRVTIKPA | PETAKKPQDA | KSSMILDICT | RYLGDVDATM | 
    1450:
    SILDISMMTG | FIPDTNDLEL | LSSGVDRYIS | KYEMDKAFSN | KNTLIIYLEK | 
    1500:
    ISHSEEDCLS | FKVHQFFNVG | LIQPGSVKVY | SYYNLEESCT | RFYHPEKDDG | 
    1550:
    MLSKLCHNEM | CRCAEENCFM | HQSQDQVSLN | ERLDKACEPG | VDYVYKTKLT | 
    1600:
    TIELSDDFDE | YIMTIEQVIK | SGSDEVQAGQ | ERRFISHVKC | RNALKLQKGK | 
    1650:
    QYLMWGLSSD | LWGEKPNTSY | IIGKDTWVEH | WPEAEERQDQ | KNQKQCEDLG | 
    1663:
    AFTETMVVFG | CPN
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    UniGene:
    SMR:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Rat Complement C3
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    E0861h
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    96T
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    ELISA Kit for Rat Complement C3
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    E0861m
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    96T
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    ELISA Kit for Rat Complement C3
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    ELISA Kit for Rat Complement C3
    Cat.:
    E0861r
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    Packing:
    96T
    ELISA Kit for Rat Complement C3
    Cat.:
    E0861b
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    Packing:
    96T
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    ELISA Kit for Rat Complement C3
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    CLIA Kit for Rat Complement C3
    Cat.:
    U0861b
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Rat Complement C3
    MSDS:
    Please sign in first.
    CLIA Kit for Rat Complement C3
    Cat.:
    U0861r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Rat Complement C3
    MSDS:
    Please sign in first.
    CLIA Kit for Rat Complement C3
    Cat.:
    U0861m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Rat Complement C3
    Cat.:
    U0861h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Rat Complement C3
    Polyclonal Antibody for Rat Complement C3
    Polyclonal Antibody for Rat Complement C3
    Cat.:
    P0861Rb-m
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Rat Complement C3
    Cat.:
    P0861Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Rat Complement C3
    Polyclonal Antibody for Rat Complement C3
    Cat.:
    P0861Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Rat Complement C3
    Monoclonal Antibody for Rat Complement C3
    Monoclonal Antibody for Rat Complement C3
    Monoclonal Antibody for Rat Complement C3
    Monoclonal Antibody for Rat Complement C3
    Monoclonal Antibody for Rat Complement C3
    Protein for Rat Complement C3
    Protein for Rat Complement C3
    Cat.:
    R0861h
    Price:
    Please sign in first.
    Packing:
    1mg
    Purity:
    >90%
    Protein for Rat Complement C3
    Protein for Rat Complement C3
    Protein for Rat Complement C3
    Protein for Rat Complement C3

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    Precision
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    Linearity
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    References
    1. 1.
      "Nucleotide and deduced amino acid sequence of rat complement C3."
      Misumi Y. , Sohda M. , Ikehara Y.
      Nucleic Acids Res.18:2178-2178(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      strain: Wistar.
      tissue: Liver.
    2. 2.
      "Complement component C3-derived neutrophil chemotactic factors purified from exudate of rat carrageenin-induced inflammation."
      Nakagawa H. , Komorita N.
      Biochem. Biophys. Res. Commun.194:1181-1187(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 568-592 AND 671-687;IDENTIFICATION OF C3A ANAPHYLATOXIN AND C3-BETA-C;FUNCTION
      tissue: Neutrophil.
    3. 3.
      "Purification, characterization, and amino acid sequence of rat anaphylatoxin (C3a)."
      Jacobs J.W. , Rubin J.S. , Hugli T.E. , Bogardt R.A. Jr. , Mariz I.K. , Daniels J.S. , Daughaday W.H. , Bradshaw R.A.
      Biochemistry17:5031-5038(1978) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 671-748
    4. 4.
      "Nucleotide and deduced amino acid sequence of rat complement component C3a derived from Sprague-Dawley strain."
      Wahrmann M. , Krieger S. , Liewehr A.
      Submitted (2000-07) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 671-748
      strain: Sprague-Dawley.
      tissue: Liver.
    5. 5.
      "Structure at 1.44 A resolution of an N-terminally truncated form of the rat serum complement C3d fragment."
      Zanotti G. , Bassetto A. , Battistutta R. , Folli C. , Arcidiaco P. , Stoppini M. , Berni R.
      Biochim. Biophys. Acta1478:232-238(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 960-969;X-RAY CRYSTALLOGRAPHY (1.44 ANGSTROMS) OF 1010-1286
    6. 6.
      "Estrogen regulation of tissue-specific expression of complement C3."
      Sundstrom S.A. , Komm B.S. , Ponce-De-Leon H. , Yi Z. , Teuscher C. , Lyttle C.R.
      J. Biol. Chem.264:16941-16947(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1316-1595
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