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Index > Protein center > Cyp26b1(Gene name) > Mouse
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  • Cyp26b1 (Gene name),
  • Cytochrome P450 26B1 (Protein name ),  CP26B_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Gene name:
    Cyp26b1;
    Protein name:
    Cytochrome P450 26B1;
    Alternative:
    Cytochrome P450 retinoic acid-inactivating 2(Cytochrome P450RAI-2);
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Involved in the metabolism of retinoic acid (RA), rendering this classical morphogen inactive through oxidation. Involved in the specific inactivation of all-trans-retinoic acid (all-trans-RA), with a preference for the following substrates: all-trans-RA > 9-cis-RA > 13-cis-RA. Generates several hydroxylated forms of RA, including 4-OH-RA, 4-oxo-RA, and 18-OH-RA. Esential for postnatal survival. Plays a central role in germ cell development: acts by degrading RA in the developing testis, preventing STRA8 expression, thereby leading to delay of meiosis. Required for the maintenance of the undifferentiated state of male germ cells during embryonic development in Sertoli cells, inducing arrest in G0 phase of the cell cycle and preventing meiotic entry. Plays a role in skeletal development, both at the level of patterning and in the ossification of bone and the establishment of some synovial joints.
    Subcellular Location:
    Endoplasmic reticulum membrane Peripheral membrane protein Microsome membrane Peripheral membrane protein
    Protein Attributes:
    Sequence length:
    512
    Sequence:
    50:
    MLFEGLELVS | ALATLAACLV | SVTLLLAVSQ | QLWQLRWAAT | RDKSCKLPIP | 
    100:
    KGSMGFPLIG | ETGHWLLQGS | GFQSSRREKY | GNVFKTHLLG | RPLIRVTGAE | 
    150:
    NVRKILLGEH | QLVSTEWPRS | ARVLLGPNTV | ANSIGDIHRN | KRKVFSKIFS | 
    200:
    HEALESYLPK | IQLVIQDTLR | AWSSQPEAIN | VYQEAQRLTF | RMAVRVLLGF | 
    250:
    SIPEEDLGHL | FEVYQQFVEN | VFSLPVDLPF | SGYRRGIQAR | QILQKGLEKA | 
    300:
    IREKLQCTQG | KDYSDALDIL | IESSKEHGKE | MTMQELKDGT | LELIFAAYAT | 
    350:
    TASASTSLIM | QLLKHPAVLE | KLREELRAQG | LLHGGGCPCE | GTLRLDTLSS | 
    400:
    LRYLDCVIKE | VMRLFTPVSG | GYRTVLQTFE | LDGFQIPKGW | SVMYSIRDTH | 
    450:
    DTAPVFKDVN | VFDPDRFSQA | RSEDKDGRFH | YLPFGGGVRT | CLGKHLAKLF | 
    500:
    LKVLAVELAS | TSRFELATRT | FPRITLVPVL | HPVDGLSVKF | FGLDSNQNEI | 
    512:
    LPETEAMLSA | TV
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    UniGene:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Cytochrome P450 26B1
    Cat.:
    E10326b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Mouse Cytochrome P450 26B1
    Cat.:
    E10326r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Mouse Cytochrome P450 26B1
    Cat.:
    E10326h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Mouse Cytochrome P450 26B1
    Cat.:
    E10326m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Cytochrome P450 26B1
    Cat.:
    U10326r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Cytochrome P450 26B1
    Cat.:
    U10326m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Cytochrome P450 26B1
    Cat.:
    U10326b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Cytochrome P450 26B1
    Cat.:
    U10326h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Mouse Cytochrome P450 26B1
    Cat.:
    P10326Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse Cytochrome P450 26B1
    Cat.:
    P10326Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse Cytochrome P450 26B1
    Polyclonal Antibody for Mouse Cytochrome P450 26B1
    Cat.:
    P10326Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Mouse Cytochrome P450 26B1
    Monoclonal Antibody for Mouse Cytochrome P450 26B1
    Monoclonal Antibody for Mouse Cytochrome P450 26B1
    Monoclonal Antibody for Mouse Cytochrome P450 26B1
    Protein for Mouse Cytochrome P450 26B1
    Protein for Mouse Cytochrome P450 26B1
    Protein for Mouse Cytochrome P450 26B1
    Protein for Mouse Cytochrome P450 26B1

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    References
    1. 1.
      "Sexually dimorphic gene expression in the developing mouse gonad."
      Menke D.B. , Page D.C.
      Gene Expr. Patterns2:359-367(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY
      strain: C57BL/6.
      tissue: Testis.
    2. 2.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6J.
      tissue: Embryo.
      tissue: Mammary gland.
    3. 3.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
      strain: C57BL/6J.
    4. 4.
      Mural R.J. , Adams M.D. , Myers E.W. , Smith H.O. , Venter J.C.
      Submitted (2005-07) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6.
      tissue: Brain.
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE;DEVELOPMENTAL STAGE
    7. 7.
      "Retinoic acid regulates sex-specific timing of meiotic initiation in mice."
      Koubova J. , Menke D.B. , Zhou Q. , Capel B. , Griswold M.D. , Page D.C.
      Proc. Natl. Acad. Sci. U.S.A.103:2474-2479(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DEVELOPMENTAL STAGE
    8. 8.
      "Cyp26b1 expression in murine Sertoli cells is required to maintain male germ cells in an undifferentiated state during embryogenesis."
      Li H. , MacLean G. , Cameron D. , Clagett-Dame M. , Petkovich M.
      PLoS ONE4:E7501-E7501(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    9. 9.
      "Craniosynostosis and multiple skeletal anomalies in humans and zebrafish result from a defect in the localized degradation of retinoic acid."
      Laue K. , Pogoda H.M. , Daniel P.B. , van Haeringen A. , Alanay Y. , von Ameln S. , Rachwalski M. , Morgan T. , Gray M.J. , Breuning M.H. , Sawyer G.M. , Sutherland-Smith A.J. , Nikkels P.G. , Kubisch C. , Bloch W. , Wollnik B. , Hammerschmidt M. , Robertson S.P.
      Am. J. Hum. Genet.89:595-606(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN SKELETAL DEVELOPMENT
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