CYP2E1 ELISA Kit for Human(Homo sapiens) | EIAab.comCYP2E1 ELISA Kit for Human(Homo sapiens)

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Index > Protein center > CYP2E1(Gene name) > Human

CYP2E1 (Gene name),

Cytochrome P450 2E1 (Protein name ), CP2E1_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

CYP2E1(CYP2E);

Protein name:

Cytochrome P450 2E1;

Alternative:

CYPIIE1;1.14.13.n7;4-nitrophenol 2-hydroxylase);Cytochrome P450-J;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

N/A

Function:

Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Inactivates a number of drugs and xenobiotics and also bioactivates many xenobiotic substrates to their hepatotoxic or carcinogenic forms.

Subcellular Location:

Endoplasmic reticulum membrane Peripheral membrane protein Microsome membrane Peripheral membrane protein

Protein Attributes:

Sequence length:

493

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

493:

LCAILQHFNL | KPLVDPKDID | LSPIHIGFGC | IPPRYKLCVI | PRS

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

MIM:

124040

STRING:

9606.ENSP00000252945

String:

P05181

UniGene:

Hs.12907

SMR:

P05181

Pfam:

PF00067

KEGG:

hsa:1571

Uniprot:

P05181

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ELISA Kit for Human Cytochrome P450 2E1

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E0988h

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96T

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ELISA Kit for Human Cytochrome P450 2E1

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E0988r

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96T

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ELISA Kit for Human Cytochrome P450 2E1

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E0988d

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96T

ELISA Kit for Human Cytochrome P450 2E1

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ELISA Kit for Human Cytochrome P450 2E1

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E0988b

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96T

ELISA Kit for Human Cytochrome P450 2E1

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E0988m

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96T

ELISA Kit for Human Cytochrome P450 2E1

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E0988p

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96T

CLIA Kit for Human Cytochrome P450 2E1

Cat.:

U0988h

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96T

CLIA Kit for Human Cytochrome P450 2E1

Cat.:

U0988b

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96T

CLIA Kit for Human Cytochrome P450 2E1

Cat.:

U0988r

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Manual:

Looking for manual.

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Packing:

96T

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CLIA Kit for Human Cytochrome P450 2E1

MSDS:

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CLIA Kit for Human Cytochrome P450 2E1

Cat.:

U0988d

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Packing:

96T

CLIA Kit for Human Cytochrome P450 2E1

Cat.:

U0988p

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96T

CLIA Kit for Human Cytochrome P450 2E1

Cat.:

U0988m

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96T

Polyclonal Antibody for Human Cytochrome P450 2E1

Cat.:

P0988Rb-m

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40ug/0.2ml

Polyclonal Antibody for Human Cytochrome P450 2E1

Cat.:

P0988Rb-r

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40ug/0.2ml

Polyclonal Antibody for Human Cytochrome P450 2E1

Cat.:

P0988Rb-h

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40ug/0.2ml

Monoclonal Antibody for Human Cytochrome P450 2E1

Protein for Human Cytochrome P450 2E1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Complementary DNA and protein sequences of ethanol-inducible rat and human cytochrome P-450s. Transcriptional and post-transcriptional regulation of the rat enzyme."
Song B.-J. , Gelboin H.V. , Park S.-S. , Yang C.S. , Gonzalez F.J.
J. Biol. Chem.261:16689-16697(1986) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
2.

"Human ethanol-inducible P450IIE1: complete gene sequence, promoter characterization, chromosome mapping, and cDNA-directed expression."
Umeno M. , McBride O.W. , Yang C.S. , Gelboin H.V. , Gonzalez F.J.
Biochemistry27:9006-9013(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
3.

"Sequence of a new human cytochrome P450-2E1 cDNA and establishing the transgenic cell line."
Zhuge J. , Qian Y. , Xie H. , Yu Y.
Submitted (1999-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Liver.
4.

NIEHS SNPs program
Submitted (2006-04) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS ASP-219; CYS-366 AND LEU-457
5.

"The DNA sequence and comparative analysis of human chromosome 10."
Deloukas P. , Earthrowl M.E. , Grafham D.V. , Rubenfield M. , French L. , Steward C.A. , Sims S.K. , Jones M.C. , Searle S. , Scott C. , Howe K. , Hunt S.E. , Andrews T.D. , Gilbert J.G.R. , Swarbreck D. , Ashurst J.L. , Taylor A. , Battles J. , more...
Nature429:375-381(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
8.

"Partial sequence of human brain cytochrome P450 2E1."
Yoo M. , Shin S.W.
Submitted (1998-08) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 32-493
tissue: Brain.
9.

"Rapid detection of a novel mutation in the human CYP2EI exon VIII by the PCR method."
Iwahashi K. , Okuyama E. , Nakamura K. , Furukawa A. , Ichikawa Y.
Submitted (1995-04) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 387-432
10.

"Purification and characterization of human liver cytochrome P-450-ALC."
Lasker J.M. , Raucy J. , Kubota S. , Bloswick B.P. , Black M. , Lieber C.S.
Biochem. Biophys. Res. Commun.148:232-238(1987) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 1-20
tissue: Liver.
11.

"Human liver cytochrome P-450 related to a rat acetone-inducible, nitrosamine-metabolizing cytochrome P-450: identification and isolation."
Robinson R.C. , Shorr R.G. , Varrichio A. , Park S.S. , Gelboin H.V. , Miller H. , Friedman F.K.
Pharmacology39:137-144(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 3-20
12.

"Expression of modified human cytochrome P450 2E1 in Escherichia coli, purification, and spectral and catalytic properties."
Gillam E.M. , Guo Z. , Guengerich F.P.
Arch. Biochem. Biophys.312:59-66(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 23-42
13.

"Both cytochromes P450 2E1 and 3A are involved in the O-hydroxylation of p-nitrophenol, a catalytic activity known to be specific for P450 2E1."
Zerilli A. , Ratanasavanh D. , Lucas D. , Goasduff T. , Dreano Y. , Menard C. , Picart D. , Berthou F.
Chem. Res. Toxicol.10:1205-1212(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CATALYTIC ACTIVITY
14.

"Structures of human cytochrome P-450 2E1. Insights into the binding of inhibitors and both small molecular weight and fatty acid substrates."
Porubsky P.R. , Meneely K.M. , Scott E.E.
J. Biol. Chem.283:33698-33707(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 32-493 IN COMPLEX WITH THE INHIBITORS INDAZOLE AND 4-METHYLPYRAZOLE AND HEME
15.

"Genetic polymorphism of human CYP2E1: characterization of two variant alleles."
Hu Y. , Oscarson M. , Johansson I. , Yue Q.Y. , Dahl M.L. , Tabone M. , Arinco S. , Albano E. , Ingelman-Sundberg M.
Mol. Pharmacol.51:370-376(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS CYP2E1*2 HIS-76 AND CYP2E1*3 ILE-389
16.

"Detection and characterization of novel polymorphisms in the CYP2E1 gene."
Fairbrother K.S. , Grove J. , de Waziers I. , Steimel D.T. , Day C.P. , Crespi C.L. , Daly A.K.
Pharmacogenetics8:543-552(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT CYP2E1*4 ILE-179
17.

"Genetic variation in eleven phase I drug metabolism genes in an ethnically diverse population."
Solus J.F. , Arietta B.J. , Harris J.R. , Sexton D.P. , Steward J.Q. , McMunn C. , Ihrie P. , Mehall J.M. , Edwards T.L. , Dawson E.P.
Pharmacogenomics5:895-931(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS ILE-179 AND LEU-457

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