Protein name:
Caspase-3 (CASP-3) ;
Alternative:
Organism:
Pig (Sus scrofa).
General Annotation
Sub Unit:
Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 17 kDa (p17) and a 12 kDa (p12) subunit (By similarity). Subunit p17 interacts with asfivirus A224L protein.
Function:
Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9.
Subcellular Location:
Cytoplasm
Protein Attributes:
50:
MENNKTSVDS | KSIKTLETKI | LHGSKSMDSG | ISLDVSYKMD | YPEMGLCIII |
100:
NNKNFDKNTG | MACRSGTDVD | AANLRETFTN | LKYEVRNKND | LTREEILELM |
150:
HSVSKEDHSK | RSSFICVLLS | HGEEGKIFGT | NGPVDLKKLT | SFFRGDCCRT |
200:
LTGKPKLFII | QACRGTELDC | GIETDSGTED | DMACQKIPVE | ADFLYAYSTA |
250:
PGYYSWRNSK | DGSWFIQSLC | AALKQYVHKL | ELMHILTRVN | RKVAVEFESF |
277:
STDSTFHAKK | QIPCIVSMLT | KELYFYH
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Bovine
Human
Mouse
Rat
Pig
Rabbit
Dog
Polyclonal Antibody for Pig CASP-3
Polyclonal Antibody for Pig CASP-3
Polyclonal Antibody for Pig CASP-3
Polyclonal Antibody for Pig CASP-3
Polyclonal Antibody for Pig CASP-3
Polyclonal Antibody for Pig CASP-3
Polyclonal Antibody for Pig CASP-3
Monoclonal Antibody for Pig CASP-3
Monoclonal Antibody for Pig CASP-3
Monoclonal Antibody for Pig CASP-3
Monoclonal Antibody for Pig CASP-3
Monoclonal Antibody for Pig CASP-3
Monoclonal Antibody for Pig CASP-3
Monoclonal Antibody for Pig CASP-3
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH ASFIVIRUS A224L