Protein name:
Cartilage oligomeric matrix protein (COMP) ;
Alternative:
Thrombospondin-5 (TSP5) ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Pentamer; disulfide-linked. Exists in a more compact conformation in the presence of calcium and shows a more extended conformation in the absence of calcium. Interacts with ITGB3, ITGA5 and FN1. Binding to FN1 requires the presence of divalent cations (Ca(2+), Mg(2+) or Mn(2+)). The greatest amount of binding is seen in the presence of Mn(2+). Interacts with MATN1, MATN3, MATN4 and ACAN. Binds heparin, heparan sulfate and chondroitin sulfate. EDTA dimishes significantly its binding to ACAN and abolishes its binding to MATN3, MATN4 and chondroitin sulfate. Interacts with collagen I, II and IX, and interaction with these collagens is dependent on the presence of zinc ions. Interacts with ADAMTS12. Interacts with ITGA7.
Function:
May play a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin. Can mediate the interaction of chondrocytes with the cartilage extracellular matrix through interaction with cell surface integrin receptors. Could play a role in the pathogenesis of osteoarthritis. Potent suppressor of apoptosis in both primary chondrocytes and transformed cells. Suppresses apoptosis by blocking the activation of caspase-3 and by inducing the IAP family of survival proteins (BIRC3, BIRC2, BIRC5 and XIAP). Essential for maintaining a vascular smooth muscle cells (VSMCs) contractile/differentiated phenotype under physiological and pathological stimuli. Maintains this phenotype of VSMCs by interacting with ITGA7.
Subcellular Location:
Secreted
extracellular space
extracellular matrix
Protein Attributes:
50:
MVPDTACVLL | LTLAALGASG | QGQSPLGSDL | GPQMLRELQE | TNAALQDVRE |
100:
LLRQQVREIT | FLKNTVMECD | ACGMQQSVRT | GLPSVRPLLH | CAPGFCFPGV |
150:
ACIQTESGAR | CGPCPAGFTG | NGSHCTDVNE | CNAHPCFPRV | RCINTSPGFR |
200:
CEACPPGYSG | PTHQGVGLAF | AKANKQVCTD | INECETGQHN | CVPNSVCINT |
250:
RGSFQCGPCQ | PGFVGDQASG | CQRRAQRFCP | DGSPSECHEH | ADCVLERDGS |
300:
RSCVCAVGWA | GNGILCGRDT | DLDGFPDEKL | RCPERQCRKD | NCVTVPNSGQ |
350:
EDVDRDGIGD | ACDPDADGDG | VPNEKDNCPL | VRNPDQRNTD | EDKWGDACDN |
400:
CRSQKNDDQK | DTDQDGRGDA | CDDDIDGDRI | RNQADNCPRV | PNSDQKDSDG |
450:
DGIGDACDNC | PQKSNPDQAD | VDHDFVGDAC | DSDQDQDGDG | HQDSRDNCPT |
500:
VPNSAQEDSD | HDGQGDACDD | DDDNDGVPDS | RDNCRLVPNP | GQEDADRDGV |
550:
GDVCQDDFDA | DKVVDKIDVC | PENAEVTLTD | FRAFQTVVLD | PEGDAQIDPN |
600:
WVVLNQGREI | VQTMNSDPGL | AVGYTAFNGV | DFEGTFHVNT | VTDDDYAGFI |
650:
FGYQDSSSFY | VVMWKQMEQT | YWQANPFRAV | AEPGIQLKAV | KSSTGPGEQL |
700:
RNALWHTGDT | ESQVRLLWKD | PRNVGWKDKK | SYRWFLQHRP | QVGYIRVRFY |
750:
EGPELVADSN | VVLDTTMRGG | RLGVFCFSQE | NIIWANLRYR | CNDTIPEDYE |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Rat
Bovine
Polyclonal Antibody for Human COMP
Polyclonal Antibody for Human COMP
Polyclonal Antibody for Human COMP
Polyclonal Antibody for Human COMP
Monoclonal Antibody for Human COMP
Monoclonal Antibody for Human COMP
Monoclonal Antibody for Human COMP
Monoclonal Antibody for Human COMP
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue :
Ovary .
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[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 326-344;VARIANT EDM1 TYR-342;VARIANT PSACH ARG-328
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE;CALCIUM-BINDING;INTERACTION WITH COLLAGEN I; COLLAGEN II AND COLLAGEN IX;CHARACTERIZATION OF VARIANT PSACH ASP-469 DEL;CHARACTERIZATION OF VARIANT EDM1 TYR-361
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH MATN1; MATN3 AND MATN4
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INTERACTION WITH ITGB3 AND ITGA5
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;TISSUE SPECIFICITY;DEVELOPMENTAL STAGE
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH ADAMTS12
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH ACAN; HEPARIN; HEPARAN SULFATE AND CHONDROITIN SULFATE
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;DOMAINS
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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"Mutations in exon 17B of cartilage oligomeric matrix protein (COMP) cause pseudoachondroplasia."
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Wang Y.
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Elder F.F.B.
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Nat. Genet.10:325-329(1995)
[
PubMed ]
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Europe PMC ]
[
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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19.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT EDM1 LYS-523
20.
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Cited for : VARIANT EDM1 SER-371;VARIANT PSACH 513-VAL--LYS-516 DEL
21.
"Diverse mutations in the gene for cartilage oligomeric matrix protein in the pseudoachondroplasia-multiple epiphyseal dysplasia disease spectrum."
Briggs M.D.
,
Mortier G.R.
,
Cole W.G.
,
King L.M.
,
Golik S.S.
,
Bonaventure J.
,
Nuytinck L.
,
de Paepe A.
,
Leroy J.G.
,
Biesecker L.
,
Lipson M.
,
Wilcox W.R.
,
Lachman R.S.
,
Rimoin D.L.
,
Knowlton R.G.
,
Cohn D.H.
Am. J. Hum. Genet.62:311-319(1998)
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Europe PMC ]
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Abstract ]
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Cited for : VARIANTS PSACH;VARIANTS EDM1 SER-453 AND ARG-585
22.
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Cited for : VARIANTS PSACH AND EDM1
23.
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Cited for : VARIANTS PSACH ARG-328; ASP-372 DEL; 391-PRO--ASP-394 DELINS VAL; ARG-440; SER-459 DEL; TYR-468; ASP-469 DEL AND TYR-472;VARIANTS EDM1 TYR-342; TYR-361; 367-ARG-GLY-368 DEL AND TYR-408
24.
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Cited for : VARIANT PSACH GLY-482
25.
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Cited for : VARIANT PSACH ARG-348
26.
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Cited for : VARIANT PSACH ASP-719
27.
"A mutation in COL9A1 causes multiple epiphyseal dysplasia: further evidence for locus heterogeneity."
Czarny-Ratajczak M.
,
Lohiniva J.
,
Rogala P.
,
Kozlowski K.
,
Peraelae M.
,
Carter L.
,
Spector T.D.
,
Kolodziej L.
,
Seppaenen U.
,
Glazar R.
,
Krolewski J.
,
Latos-Bielenska A.
,
Ala-Kokko L.
Am. J. Hum. Genet.69:969-980(2001)
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PubMed ]
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Europe PMC ]
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Cited for : VARIANTS EDM1 ARG-276; ALA-420 AND MET-585
28.
"Pseudoachondroplasia and multiple epiphyseal dysplasia: A 7-year comprehensive analysis of the known disease genes identify novel and recurrent mutations and provides an accurate assessment of their relative contribution."
Jackson G.C.
,
Mittaz-Crettol L.
,
Taylor J.A.
,
Mortier G.R.
,
Spranger J.
,
Zabel B.
,
Le Merrer M.
,
Cormier-Daire V.
,
Hall C.M.
,
Offiah A.
,
Wright M.J.
,
Savarirayan R.
,
Nishimura G.
,
Ramsden S.C.
,
Elles R.
,
Bonafe L.
,
Superti-Furga A.
,
Unger S.
,
Zankl A.
,
Briggs M.D.
more...
Hum. Mutat.33:144-157(2012)
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PubMed ]
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Europe PMC ]
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Cited for : VARIANTS PSACH SER-234; GLY-290; ARG-299; TYR-326; 341-GLU-ASP-342 DEL; 350-ASN--ASP-372 DEL; VAL-378; ARG-387; 402-GLY--GLY-404 DELINS VAL-CYS; ARG-440; ASN-446; SER-448; ASP-473 DEL; HIS-473; ASN-475; GLY-482; GLY-507; GLY-511; GLY-515; ILE-529; ARG-585 AND SER-719;VARIANTS EDM1 GLU-167; ARG-276; LEU-298; ASP-311; GLY-317; GLY-326; PHE-348; SER-371; TYR-371; ASN-374; ASN-376; ASN-385; ASP-385 DEL; TYR-385; HIS-397; ARG-404; TYR-410; LYS-415; GLU-427; 430-CYS--SER-432 DELINS LEU-TRP-CYS; GLU-457 DEL; ASP-473 INS; ASP-501; LYS-523; MET-585; PRO-718 AND TRP-718;VARIANT ARG-756