Protein name:
CREB-regulated transcription coactivator 2 ;
Alternative:
Transducer of regulated cAMP response element-binding protein 2 (TORC-2;Transducer of CREB protein 2) ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Binds, as a tetramer, through its N-terminal region, with the bZIP domain of CREB1. 'Arg-314' in the bZIP domain of CREB1 is essential for this interaction. Interaction, via its C-terminal, with TAF4, enhances recruitment of TAF4 to CREB1 (By similarity). Interacts with PPP3CA/calcineurin alpha, SIK2 and 14-3-3 proteins, YWHAB and YWHAG (By similarity). Interaction with RFWD2/COP1 mediates nuclear export and degradation of CRTC2.
Function:
Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway. Regulates the expression of specific genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells.
Subcellular Location:
Cytoplasm
Nucleus
Translocated from the nucleus to the cytoplasm on interaction of the phosphorylated form with 14-3-3 protein. In response to cAMP levels and glucagon, relocated to the nucleus.
Protein Attributes:
50:
MATSGANGPG | SATASASNPR | KFSEKIALQK | QRQAEETAAF | EEVMMDIGST |
100:
RLQAQKLRLA | YTRSSHYGGS | LPNVNQIGCG | LAEFQSPLHS | PLDSSRSTRH |
150:
HGLVERVQRD | ARRMVSPLRR | YPRHIDSSPY | SPAYLSPPPE | SGWRRMMPWG |
200:
NLPAEKGQLF | RLPSALNRTS | SDSALHTSVM | NPNPQDTYPG | PTPPSVLPSR |
250:
RGGGFLDGEM | DAKVPAIEEN | VVDDKHLLKP | WDAKKLSSSS | SRPRSCEVPG |
300:
INIFPSPDQP | ANVPVLPPAM | NTGGSLPDLT | NLHFPPPLPT | PLDPEETVYP |
350:
SLSGGNSTTN | LTHTMTHLGI | SGGLGLGPSY | DVPGLHSPLS | HPSLQSSLSN |
400:
PNLQASLSSP | QPQLQGSHSH | PSLPASSLAH | HALPTTSLGH | PSLSAPALSS |
450:
SSSSSSTSSP | VLSAPPYPAS | TPGASPRHRR | VPLSPLSLPA | GPADARRSQQ |
500:
QLPKQFSPTM | SPTLSSITQG | VPLDTSKLPT | DQRLPPYPYS | PPSLVIPTHP |
550:
PTPKSLQQLP | SQACLVQPSG | GQPPGRQPHY | GALYPPGSSG | HGQQPYHRPI |
600:
NDFSLGNLEQ | FNMESPSTSL | VLDPPAFSEG | PGFLGSEGSM | SGPQDPHVLN |
650:
HQNLTHCSRH | GSGPNIILTG | DSSPGFSKEI | AAALAGVPGF | EVSASGLELG |
692:
LGLEDELRME | PLGLEGLTML | SDPCALLPDP | AVEDSFRSDR | LQ
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Rat
Bovine
ELISA Kit for Mouse CREB-regulated transcription coactivator 2
ELISA Kit for Mouse CREB-regulated transcription coactivator 2
ELISA Kit for Mouse CREB-regulated transcription coactivator 2
ELISA Kit for Mouse CREB-regulated transcription coactivator 2
CLIA Kit for Mouse CREB-regulated transcription coactivator 2
CLIA Kit for Mouse CREB-regulated transcription coactivator 2
CLIA Kit for Mouse CREB-regulated transcription coactivator 2
CLIA Kit for Mouse CREB-regulated transcription coactivator 2
Polyclonal Antibody for Mouse CREB-regulated transcription coactivator 2
Polyclonal Antibody for Mouse CREB-regulated transcription coactivator 2
Polyclonal Antibody for Mouse CREB-regulated transcription coactivator 2
Polyclonal Antibody for Mouse CREB-regulated transcription coactivator 2
Monoclonal Antibody for Mouse CREB-regulated transcription coactivator 2
Monoclonal Antibody for Mouse CREB-regulated transcription coactivator 2
Monoclonal Antibody for Mouse CREB-regulated transcription coactivator 2
Monoclonal Antibody for Mouse CREB-regulated transcription coactivator 2
Protein for Mouse CREB-regulated transcription coactivator 2
Protein for Mouse CREB-regulated transcription coactivator 2
Protein for Mouse CREB-regulated transcription coactivator 2
Protein for Mouse CREB-regulated transcription coactivator 2
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
"The transcriptional landscape of the mammalian genome."
Carninci P.
,
Kasukawa T.
,
Katayama S.
,
Gough J.
,
Frith M.C.
,
Maeda N.
,
Oyama R.
,
Ravasi T.
,
Lenhard B.
,
Wells C.
,
Kodzius R.
,
Shimokawa K.
,
Bajic V.B.
,
Brenner S.E.
,
Batalov S.
,
Forrest A.R.
,
Zavolan M.
,
Davis M.J.
,
Wilming L.G.
,
Aidinis V.
,
Allen J.E.
,
Ambesi-Impiombato A.
,
Apweiler R.
,
Aturaliya R.N.
,
Bailey T.L.
,
Bansal M.
,
Baxter L.
,
Beisel K.W.
,
Bersano T.
,
Bono H.
,
Chalk A.M.
,
Chiu K.P.
,
Choudhary V.
,
Christoffels A.
,
Clutterbuck D.R.
,
Crowe M.L.
,
Dalla E.
,
Dalrymple B.P.
,
de Bono B.
,
Della Gatta G.
,
di Bernardo D.
,
Down T.
,
Engstrom P.
,
Fagiolini M.
,
Faulkner G.
,
Fletcher C.F.
,
Fukushima T.
,
Furuno M.
,
Futaki S.
,
Gariboldi M.
,
Georgii-Hemming P.
,
Gingeras T.R.
,
Gojobori T.
,
Green R.E.
,
Gustincich S.
,
Harbers M.
,
Hayashi Y.
,
Hensch T.K.
,
Hirokawa N.
,
Hill D.
,
Huminiecki L.
,
Iacono M.
,
Ikeo K.
,
Iwama A.
,
Ishikawa T.
,
Jakt M.
,
Kanapin A.
,
Katoh M.
,
Kawasawa Y.
,
Kelso J.
,
Kitamura H.
,
Kitano H.
,
Kollias G.
,
Krishnan S.P.
,
Kruger A.
,
Kummerfeld S.K.
,
Kurochkin I.V.
,
Lareau L.F.
,
Lazarevic D.
,
Lipovich L.
,
Liu J.
,
Liuni S.
,
McWilliam S.
,
Madan Babu M.
,
Madera M.
,
Marchionni L.
,
Matsuda H.
,
Matsuzawa S.
,
Miki H.
,
Mignone F.
,
Miyake S.
,
Morris K.
,
Mottagui-Tabar S.
,
Mulder N.
,
Nakano N.
,
Nakauchi H.
,
Ng P.
,
Nilsson R.
,
Nishiguchi S.
,
Nishikawa S.
,
Nori F.
,
Ohara O.
,
Okazaki Y.
,
Orlando V.
,
Pang K.C.
,
Pavan W.J.
,
Pavesi G.
,
Pesole G.
,
Petrovsky N.
,
Piazza S.
,
Reed J.
,
Reid J.F.
,
Ring B.Z.
,
Ringwald M.
,
Rost B.
,
Ruan Y.
,
Salzberg S.L.
,
Sandelin A.
,
Schneider C.
,
Schoenbach C.
,
Sekiguchi K.
,
Semple C.A.
,
Seno S.
,
Sessa L.
,
Sheng Y.
,
Shibata Y.
,
Shimada H.
,
Shimada K.
,
Silva D.
,
Sinclair B.
,
Sperling S.
,
Stupka E.
,
Sugiura K.
,
Sultana R.
,
Takenaka Y.
,
Taki K.
,
Tammoja K.
,
Tan S.L.
,
Tang S.
,
Taylor M.S.
,
Tegner J.
,
Teichmann S.A.
,
Ueda H.R.
,
van Nimwegen E.
,
Verardo R.
,
Wei C.L.
,
Yagi K.
,
Yamanishi H.
,
Zabarovsky E.
,
Zhu S.
,
Zimmer A.
,
Hide W.
,
Bult C.
,
Grimmond S.M.
,
Teasdale R.D.
,
Liu E.T.
,
Brusic V.
,
Quackenbush J.
,
Wahlestedt C.
,
Mattick J.S.
,
Hume D.A.
,
Kai C.
,
Sasaki D.
,
Tomaru Y.
,
Fukuda S.
,
Kanamori-Katayama M.
,
Suzuki M.
,
Aoki J.
,
Arakawa T.
,
Iida J.
,
Imamura K.
,
Itoh M.
,
Kato T.
,
Kawaji H.
,
Kawagashira N.
,
Kawashima T.
,
Kojima M.
,
Kondo S.
,
Konno H.
,
Nakano K.
,
Ninomiya N.
,
Nishio T.
,
Okada M.
,
Plessy C.
,
Shibata K.
,
Shiraki T.
,
Suzuki S.
,
Tagami M.
,
Waki K.
,
Watahiki A.
,
Okamura-Oho Y.
,
Suzuki H.
,
Kawai J.
,
Hayashizaki Y.
more...
Science309:1559-1563(2005)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain :
NOD .
tissue :
Spleen .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain :
FVB/N .
tissue :
Liver .
tissue :
Mammary tumor .
tissue :
Salivary gland .
3.
"The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism."
Koo S.-H.
,
Flechner L.
,
Qi L.
,
Zhang X.
,
Screaton R.A.
,
Jeffries S.
,
Hedrick S.
,
Xu W.
,
Boussouar F.
,
Brindle P.
,
Takemori H.
,
Montminy M.
Nature437:1109-1111(2005)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;SUBCELLULAR LOCATION;PHOSPHORYLATION AT SER-171;TISSUE SPECIFICITY
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;PHOSPHORYLATION AT SER-171;SUBCELLULAR LOCATION
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH RFWD2;PHOSPHORYLATION AT SER-171;SUBCELLULAR LOCATION;MUTAGENESIS OF SER-171; VAL-214; PRO-215 AND LYS-628
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-612;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Liver .
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : TISSUE SPECIFICITY
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : METHYLATION AT ARG-51; ARG-99; ARG-120; ARG-123; ARG-161 AND ARG-168