Crtc2 ELISA Kit for Rat(Rattus norvegicus) | EIAab.comCrtc2 ELISA Kit for Rat(Rattus norvegicus)

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Crtc2 (Gene name),

CREB-regulated transcription coactivator 2 (Protein name ), CRTC2_RAT from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

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Gene name:

Crtc2(Torc2);

Protein name:

CREB-regulated transcription coactivator 2;

Alternative:

Transducer of regulated cAMP response element-binding protein 2(TORC-2;Transducer of CREB protein 2);

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

Binds, as a tetramer, through its N-terminal region, with the bZIP domain of CREB1. 'Arg-314' in the bZIP domain of CREB1 is essential for this interaction. Interaction, via its C-terminal, with TAF4, enhances recruitment of TAF4 to CREB1 (By similarity). Interacts with PPP3CA/calcineurin alpha, SIK2 and 14-3-3 proteins, YWHAB and YWHAG. Interaction with RFWD2/COP1 mediates nuclear export and degradation of CRTC2.

Function:

Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway. Regulates the expression of specific genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells.

Subcellular Location:

Cytoplasm Nucleus Translocated from the nucleus to the cytoplasm on interaction of the phosphorylated form with 14-3-3 protein. In response to cAMP levels and glucagon, relocated to the nucleus.

Protein Attributes:

Sequence length:

691

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

691:

GLEDELRMEP | LGLEGLTMLS | DPCALLPDPA | VEDSFRSDRL | Q

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Rn.13599

Pfam:

PF12886

String:

Q3LRZ1

KEGG:

rno:310615

Uniprot:

Q3LRZ1

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ELISA Kit for Rat CREB-regulated transcription coactivator 2

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E10676h

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ELISA Kit for Rat CREB-regulated transcription coactivator 2

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E10676m

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96T

ELISA Kit for Rat CREB-regulated transcription coactivator 2

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E10676r

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ELISA Kit for Rat CREB-regulated transcription coactivator 2

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E10676b

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96T

CLIA Kit for Rat CREB-regulated transcription coactivator 2

Cat.:

U10676r

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96T

CLIA Kit for Rat CREB-regulated transcription coactivator 2

Cat.:

U10676h

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MSDS:

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Packing:

96T

CLIA Kit for Rat CREB-regulated transcription coactivator 2

Cat.:

U10676b

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MSDS:

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Packing:

96T

CLIA Kit for Rat CREB-regulated transcription coactivator 2

Cat.:

U10676m

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MSDS:

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Packing:

96T

Polyclonal Antibody for Rat CREB-regulated transcription coactivator 2

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P10676Rb-r

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40ug/0.2ml

Polyclonal Antibody for Rat CREB-regulated transcription coactivator 2

Cat.:

P10676Rb-m

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40ug/0.2ml

Polyclonal Antibody for Rat CREB-regulated transcription coactivator 2

Cat.:

P10676Rb-h

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Packing:

40ug/0.2ml

Monoclonal Antibody for Rat CREB-regulated transcription coactivator 2

Protein for Rat CREB-regulated transcription coactivator 2

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"TORC2 in central nervous system."
Wu H. , Miao S. , Shen H. , Xiong Z.
Submitted (2005-08) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
strain: Sprague-Dawley.

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