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Index > Protein center > SLC5A1(Gene name) > Human
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  • SLC5A1 (Gene name),
  • Sodium/glucose cotransporter 1 (Protein name ),  SC5A1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    SLC5A1(NAGT;SGLT1);
    Protein name:
    Sodium/glucose cotransporter 1(Na(+)/glucose cotransporter 1);
    Alternative:
    Solute carrier family 5 member 1;High affinity sodium-glucose cotransporter;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Actively transports glucose into cells by Na(+) cotransport with a Na(+) to glucose coupling ratio of 2:1. Efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity high capacity and a high affinity low capacity Na(+)/glucose cotransporter arranged in series along kidney proximal tubules.
    Subcellular Location:
    Membrane Multi-pass membrane protein
    Protein Attributes:
    Sequence length:
    664
    Sequence:
    50:
    MDSSTWSPKT | TAVTRPVETH | ELIRNAADIS | IIVIYFVVVM | AVGLWAMFST | 
    100:
    NRGTVGGFFL | AGRSMVWWPI | GASLFASNIG | SGHFVGLAGT | GAASGIAIGG | 
    150:
    FEWNALVLVV | VLGWLFVPIY | IKAGVVTMPE | YLRKRFGGQR | IQVYLSLLSL | 
    200:
    LLYIFTKISA | DIFSGAIFIN | LALGLNLYLA | IFLLLAITAL | YTITGGLAAV | 
    250:
    IYTDTLQTVI | MLVGSLILTG | FAFHEVGGYD | AFMEKYMKAI | PTIVSDGNTT | 
    300:
    FQEKCYTPRA | DSFHIFRDPL | TGDLPWPGFI | FGMSILTLWY | WCTDQVIVQR | 
    350:
    CLSAKNMSHV | KGGCILCGYL | KLMPMFIMVM | PGMISRILYT | EKIACVVPSE | 
    400:
    CEKYCGTKVG | CTNIAYPTLV | VELMPNGLRG | LMLSVMLASL | MSSLTSIFNS | 
    450:
    ASTLFTMDIY | AKVRKRASEK | ELMIAGRLFI | LVLIGISIAW | VPIVQSAQSG | 
    500:
    QLFDYIQSIT | SYLGPPIAAV | FLLAIFWKRV | NEPGAFWGLI | LGLLIGISRM | 
    550:
    ITEFAYGTGS | CMEPSNCPTI | ICGVHYLYFA | IILFAISFIT | IVVISLLTKP | 
    600:
    IPDVHLYRLC | WSLRNSKEER | IDLDAEEENI | QEGPKETIEI | ETQVPEKKKG | 
    650:
    IFRRAYDLFC | GLEQHGAPKM | TEEEEKAMKM | KMTDTSEKPL | WRTVLNVNGI | 
    664:
    ILVTVAVFCH | AYFA
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    MIM:
    UniGene:
    KEGG:
    String:
    Pfam:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Human Na(+)/glucose cotransporter 1
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    E0658r
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    ELISA Kit for Human Na(+)/glucose cotransporter 1
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    E0658h
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    ELISA Kit for Human Na(+)/glucose cotransporter 1
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    E0658m
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    Packing:
    96T
    ELISA Kit for Human Na(+)/glucose cotransporter 1
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    E0658p
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Human Na(+)/glucose cotransporter 1
    MSDS:
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    CLIA Kit for Human Na(+)/glucose cotransporter 1
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    U0658r
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Na(+)/glucose cotransporter 1
    Cat.:
    U0658p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Na(+)/glucose cotransporter 1
    MSDS:
    Please sign in first.
    CLIA Kit for Human Na(+)/glucose cotransporter 1
    Cat.:
    U0658m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Na(+)/glucose cotransporter 1
    Cat.:
    U0658h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Na(+)/glucose cotransporter 1
    Polyclonal Antibody for Human Na(+)/glucose cotransporter 1
    Polyclonal Antibody for Human Na(+)/glucose cotransporter 1
    Cat.:
    P0658Rb-h
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Na(+)/glucose cotransporter 1
    Cat.:
    P0658Rb-m
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Na(+)/glucose cotransporter 1
    Cat.:
    P0658Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Na(+)/glucose cotransporter 1
    Monoclonal Antibody for Human Na(+)/glucose cotransporter 1
    Monoclonal Antibody for Human Na(+)/glucose cotransporter 1
    Monoclonal Antibody for Human Na(+)/glucose cotransporter 1
    Monoclonal Antibody for Human Na(+)/glucose cotransporter 1
    Protein for Human Na(+)/glucose cotransporter 1
    Protein for Human Na(+)/glucose cotransporter 1
    Protein for Human Na(+)/glucose cotransporter 1
    Protein for Human Na(+)/glucose cotransporter 1
    Protein for Human Na(+)/glucose cotransporter 1

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Homology of the human intestinal Na+/glucose and Escherichia coli Na+/proline cotransporters."
      Hediger M.A. , Turk E. , Wright E.M.
      Proc. Natl. Acad. Sci. U.S.A.86:5748-5752(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    2. 2.
      "Structure of the human Na+/glucose cotransporter gene SGLT1."
      Turk E. , Martin M.G. , Wright E.M.
      J. Biol. Chem.269:15204-15209(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT GGM GLY-28
    3. 3.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
    4. 4.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
      tissue: Heart.
      tissue: Trachea.
    5. 5.
      "The DNA sequence of human chromosome 22."
      Dunham I. , Hunt A.R. , Collins J.E. , Bruskiewich R. , Beare D.M. , Clamp M. , Smink L.J. , Ainscough R. , Almeida J.P. , Babbage A.K. , Bagguley C. , Bailey J. , Barlow K.F. , Bates K.N. , Beasley O.P. , Bird C.P. , Blakey S.E. , Bridgeman A.M. , more...
      Nature402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      "Membrane topology of the human Na+/glucose cotransporter SGLT1."
      Turk E. , Kerner C.J. , Lostao M.P. , Wright E.M.
      J. Biol. Chem.271:1925-1934(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TOPOLOGY;MUTAGENESIS OF ASN-248;GLYCOSYLATION AT ASN-248
    8. 8.
      "Glucose/galactose malabsorption caused by a defect in the Na+/glucose cotransporter."
      Turk E. , Zabel B. , Mundlos S. , Dyer J. , Wright E.M.
      Nature350:354-356(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT GGM ASN-28
    9. 9.
      "Missense mutations in SGLT1 cause glucose-galactose malabsorption by trafficking defects."
      Lam J.T. , Martin M.G. , Turk E. , Hirayama B.A. , Bosshard N.U. , Steinmann B. , Wright E.M.
      Biochim. Biophys. Acta1453:297-303(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS GGM ARG-318 AND VAL-468
    10. 10.
      "A missense mutation in the Na(+)/glucose cotransporter gene SGLT1 in a patient with congenital glucose-galactose malabsorption: normal trafficking but inactivation of the mutant protein."
      Kasahara M. , Maeda M. , Hayashi S. , Mori Y. , Abe T.
      Biochim. Biophys. Acta1536:141-147(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT GGM TRP-135
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