HIRA ELISA Kit for Human(Homo sapiens) | EIAab.comHIRA ELISA Kit for Human(Homo sapiens)

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Index > Protein center > HIRA(Gene name) > Human

HIRA (Gene name),

Protein HIRA (Protein name ), HIRA_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

HIRA(DGCR1;HIR;TUPLE1);

Protein name:

Protein HIRA;

Alternative:

TUP1-like enhancer of split protein 1;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with histone H3F3B, PAX3 and PAX7 (By similarity). Interacts with CCNA1, HIRIP3, NFU1/HIRIP5 and histone H2B. Part of a complex which includes ASF1A, CABIN1, histone H3.3, histone H4 and UBN1.

Function:

Cooperates with ASF1A to promote replication-independent chromatin assembly. Required for the periodic repression of histone gene transcription during the cell cycle. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit.

Subcellular Location:

Nucleus Nucleus PML body Primarily, though not exclusively, localized to the nucleus. Localizes to PML bodies immediately prior to onset of senescence.

Protein Attributes:

Sequence length:

1017

Sequence:

50:

100:

150:

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250:

300:

350:

400:

450:

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550:

600:

650:

700:

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800:

850:

900:

950:

1000:

1017:

QRLFTECQEQ | LDILRDK

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

STRING:

9606.ENSP00000263208

SMR:

P54198

Pfam:

PF07569

String:

P54198

KEGG:

hsa:7290

MIM:

600237

UniGene:

Hs.474206

Uniprot:

P54198

FOR

ELISA Kit for Human Protein HIRA

CLIA Kit for Human Protein HIRA

Polyclonal Antibody for Human Protein HIRA

Monoclonal Antibody for Human Protein HIRA

Protein for Human Protein HIRA

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"A human homolog of the S. cerevisiae HIR1 and HIR2 transcriptional repressors cloned from the DiGeorge syndrome critical region."
Lamour V. , Lecluse Y. , Desmaze C. , Spector M. , Bodescot M. , Aurias A. , Osley M.A. , Lipinski M.
Hum. Mol. Genet.4:791-799(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG)
tissue: Brain.
2.

"Structural organization of the WD repeat protein-encoding gene HIRA in the DiGeorge syndrome critical region of human chromosome 22."
Lorain S. , Demczuk S. , Lamour V. , Toth S. , Aurias A. , Roe B.A. , Lipinski M.
Genome Res.6:43-50(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM LONG)
3.

"A genome annotation-driven approach to cloning the human ORFeome."
Collins J.E. , Wright C.L. , Edwards C.A. , Davis M.P. , Grinham J.A. , Cole C.G. , Goward M.E. , Aguado B. , Mallya M. , Mokrab Y. , Huckle E.J. , Beare D.M. , Dunham I.
Genome Biol.5:R84.1-R84.11(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM LONG)
4.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM LONG)
tissue: Eye.
tissue: Lymph.
5.

"Isolation of a putative transcriptional regulator from the region of 22q11 deleted in DiGeorge syndrome, Shprintzen syndrome and familial congenital heart disease."
Halford S. , Wadey R. , Roberts C. , Daw S.C.M. , Whiting J.A. , O'Donnell H. , Dunham I. , Bentley D. , Lindsay E. , Baldini A. , Francis F. , Lehrach H. , Williamson R. , Wilson D.I. , Goodship J. , Cross I. , Burn J. , Scambler P.J.
Hum. Mol. Genet.2:2099-2107(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 45-1017 (ISOFORM SHORT)
tissue: Fetal brain.
6.

"The murine homologue of HIRA, a DiGeorge syndrome candidate gene, is expressed in embryonic structures affected in human CATCH22 patients."
Wilming L.G. , Snoeren C.A.S. , van Rijswijk A. , Grosveld F. , Meijers C.
Hum. Mol. Genet.6:247-258(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
7.

"Core histones and HIRIP3, a novel histone-binding protein, directly interact with WD repeat protein HIRA."
Lorain S. , Quivy J.-P. , Monier-Gavelle F. , Scamps C. , Lecluse Y. , Almouzni G. , Lipinski M.
Mol. Cell. Biol.18:5546-5556(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HIRIP3; HISTONE H2B; HISTONE H4 AND NFU1;SUBCELLULAR LOCATION
8.

"HIRA, the human homologue of yeast Hir1p and Hir2p, is a novel cyclin-cdk2 substrate whose expression blocks S-phase progression."
Hall C. , Nelson D.M. , Ye X. , Baker K. , DeCaprio J.A. , Seeholzer S. , Lipinski M. , Adams P.D.
Mol. Cell. Biol.21:1854-1865(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CCNA1;SUBCELLULAR LOCATION;PHOSPHORYLATION AT THR-555 AND SER-687;MUTAGENESIS OF THR-555 AND 628-LYS--LEU-631
9.

"Coupling of DNA synthesis and histone synthesis in S phase independent of cyclin/cdk2 activity."
Nelson D.M. , Ye X. , Hall C. , Santos H. , Ma T. , Kao G.D. , Yen T.J. , Harper J.W. , Adams P.D.
Mol. Cell. Biol.22:7459-7472(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
10.

"Structure and function of the conserved core of histone deposition protein Asf1."
Daganzo S.M. , Erzberger J.P. , Lam W.M. , Skordalakes E. , Zhang R. , Franco A.A. , Brill S.J. , Adams P.D. , Berger J.M. , Kaufman P.D.
Curr. Biol.13:2148-2158(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ASF1A
11.

"Histone H3.1 and H3.3 complexes mediate nucleosome assembly pathways dependent or independent of DNA synthesis."
Tagami H. , Ray-Gallet D. , Almouzni G. , Nakatani Y.
Cell116:51-61(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;IDENTIFICATION BY MASS SPECTROMETRY;IDENTIFICATION IN A COMPLEX WITH ASF1A; CABIN1; HISTONE H3.3 AND UBN1
12.

"Formation of MacroH2A-containing senescence-associated heterochromatin foci and senescence driven by ASF1a and HIRA."
Zhang R. , Poustovoitov M.V. , Ye X. , Santos H.A. , Chen W. , Daganzo S.M. , Erzberger J.P. , Serebriiskii I.G. , Canutescu A.A. , Dunbrack R.L. , Pehrson J.R. , Berger J.M. , Kaufman P.D. , Adams P.D.
Dev. Cell8:19-30(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH ASF1A;SUBCELLULAR LOCATION
13.

"Systematic identification and analysis of mammalian small ubiquitin-like modifier substrates."
Gocke C.B. , Yu H. , Kang J.
J. Biol. Chem.280:5004-5012(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUMOYLATION
14.

"A quantitative atlas of mitotic phosphorylation."
Dephoure N. , Zhou C. , Villen J. , Beausoleil S.A. , Bakalarski C.E. , Elledge S.J. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-584 AND THR-586;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
15.

"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
16.

"Human UBN1 is an ortholog of yeast Hpc2p and has an essential role in the HIRA/ASF1a chromatin-remodeling pathway in senescent cells."
Banumathy G. , Somaiah N. , Zhang R. , Tang Y. , Hoffmann J. , Andrake M. , Ceulemans H. , Schultz D. , Marmorstein R. , Adams P.D.
Mol. Cell. Biol.29:758-770(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH UBN1
17.

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-549; SER-557; THR-576 AND THR-586;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Leukemic T-cell.
18.

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-586 AND SER-661;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
19.

"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T. , Prokhorova T.A. , Akimov V. , Henningsen J. , Johansen P.T. , Kratchmarova I. , Kassem M. , Mann M. , Olsen J.V. , Blagoev B.
Sci. Signal.4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-610; SER-611; SER-612; SER-614 AND SER-661;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
20.

"Structure of a human ASF1a-HIRA complex and insights into specificity of histone chaperone complex assembly."
Tang Y. , Poustovoitov M.V. , Zhao K. , Garfinkel M. , Canutescu A. , Dunbrack R. , Adams P.D. , Marmorstein R.
Nat. Struct. Mol. Biol.13:921-929(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 425-472 IN COMPLEX WITH ASF1A;MUTAGENESIS OF 449-GLN--ARG-458; 459-ARG--GLN-468; ARG-459; ARG-460; ILE-461; LEU-464 AND ILE-466

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