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Index > Protein center > MVB12B(Gene name) > Human
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  • MVB12B (Gene name),
  • Multivesicular body subunit 12B (Protein name ),  MB12B_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    MVB12B(C9orf28;FAM125B);
    Protein name:
    Multivesicular body subunit 12B;
    Alternative:
    Protein FAM125B;ESCRT-I complex subunit MVB12B;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Component of the ESCRT-I complex (endosomal sorting complex required for transport I) which consists of TSG101, VPS28, a VPS37 protein (VPS37A to -D) and MVB12A or MVB12B in a 1:1:1:1 stoechiometry. Interacts with TSG101; the association appears to be mediated by the TSG101-VPS37 binary subcomplex. Interacts with VPS28. Interacts with VPS37B; the association appears to be mediated by the TSG101-VPS37 binary subcomplex. Interacts with VPS37C; the association appears to be mediated by the TSG101-VPS37 binary subcomplex.
    Function:
    Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies.
    Subcellular Location:
    Endosome Late endosome membrane Peripheral membrane protein
    Protein Attributes:
    Sequence length:
    319
    Sequence:
    50:
    MRSCFCVRRS | RDPPPPQPPP | PPPQRGTDQS | TMPEVKDLSE | ALPETSMDPI | 
    100:
    TGVGVVASRN | RAPTGYDVVA | QTADGVDADL | WKDGLFKSKV | TRYLCFTRSF | 
    150:
    SKENSHLGNV | LVDMKLIDIK | DTLPVGFIPI | QETVDTQEVA | FRKKRLCIKF | 
    200:
    IPRDSTEAAI | CDIRIMGRTK | QAPPQYTFIG | ELNSMGIWYR | MGRVPRNHDS | 
    250:
    SQPTTPSQSS | AASTPAPNLP | RHISLTLPAT | FRGRNSTRTD | YEYQHSNLYA | 
    300:
    ISAMDGVPFM | ISEKFSCVPE | SMQPFDLLGI | TIKSLAEIEK | EYEYSFRTEQ | 
    319:
    SAAARLPPSP | TRCQQIPQS
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    SMR:
    KEGG:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human Multivesicular body subunit 12B
    ELISA Kit for Human Multivesicular body subunit 12B
    CLIA Kit for Human Multivesicular body subunit 12B
    CLIA Kit for Human Multivesicular body subunit 12B
    Polyclonal Antibody for Human Multivesicular body subunit 12B
    Polyclonal Antibody for Human Multivesicular body subunit 12B
    Monoclonal Antibody for Human Multivesicular body subunit 12B
    Monoclonal Antibody for Human Multivesicular body subunit 12B
    Protein for Human Multivesicular body subunit 12B
    Protein for Human Multivesicular body subunit 12B

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    References
    1. 1.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Spleen.
    2. 2.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      tissue: Brain.
    3. 3.
      "Identification of human MVB12 proteins as ESCRT-I subunits that function in HIV budding."
      Morita E. , Sandrin V. , Alam S.L. , Eckert D.M. , Gygi S.P. , Sundquist W.I.
      Cell Host Microbe2:41-53(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TSG101; VPS28; VPS37B AND VPS37C;IDENTIFICATION IN THE ESCRT-I COMPLEX;PHOSPHORYLATION AT SER-46; SER-101; THR-122; THR-204; THR-205 AND SER-309;IDENTIFICATION BY MASS SPECTROMETRY
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