Mapk8 ELISA Kit for Rat(Rattus norvegicus) | EIAab.comMapk8 ELISA Kit for Rat(Rattus norvegicus)

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Mapk8 (Gene name),

Mitogen-activated protein kinase 8 (Protein name ), MK08_RAT from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

Citations (1)

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Gene name:

Mapk8(Jnk1;Prkm8);

Protein name:

Mitogen-activated protein kinase 8(MAP kinase 8;MAPK 8);

Alternative:

Stress-activated protein kinase JNK1;SAPK gamma;p54 gamma;c-Jun N-terminal kinase 1;

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

Binds to at least four scaffolding proteins, MAPK8IP1/JIP-1, MAPK8IP2/JIP-2, MAPK8IP3/JIP-3/JSAP1 and SPAG9/MAPK8IP4/JIP-4. These proteins also bind other components of the JNK signaling pathway. Interacts with TP53, WWOX and JAMP. Interacts with NFATC4. Interacts (phosphorylated form) with NFE2; the interaction phosphorylates NFE2 in undifferentiated cells. Interacts with MECOM; regulates JNK signaling (By similarity). Forms a complex with MAPK8IP1 and RGNEF.

Function:

Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as JUN, JDP2 and ATF2 and thus regulates AP-1 transcriptional activity. In T-cells, JNK1 and JNK2 are required for polarized differentiation of T-helper cells into Th1 cells. Phosphorylates heat shock factor protein 4 (HSF4).

Subcellular Location:

N/A

Protein Attributes:

Sequence length:

411

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

411:

SMSTDPTLAS | D

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

rno:116554

String:

P49185

UniGene:

Rn.4090

Pfam:

PF00069

STRING:

10116.ENSRNOP00000027338

SMR:

P49185

Uniprot:

P49185

FOR

ELISA Kit for Rat MAP kinase 8

Cat.:

E9092m

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Packing:

96T

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ELISA Kit for Rat MAP kinase 8

Cat.:

E9092r

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Packing:

96T

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ELISA Kit for Rat MAP kinase 8

Cat.:

E9092h

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Manual:

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96T

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CLIA Kit for Rat MAP kinase 8

Cat.:

U9092h

Price:

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Manual:

Looking for manual.

MSDS:

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Packing:

96T

Range:

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CLIA Kit for Rat MAP kinase 8

Cat.:

U9092r

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Rat MAP kinase 8

Cat.:

U9092m

Price:

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MSDS:

Please sign in first.

Packing:

96T

Polyclonal Antibody for Rat MAP kinase 8

Cat.:

P9092Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Rat MAP kinase 8

Cat.:

P9092Rb-h

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Rat MAP kinase 8

Monoclonal Antibody for Rat MAP kinase 8

Protein for Rat MAP kinase 8

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

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Citations

[1].

"Pharmacological Manipulation of Trk, p75NTR, and NGF Balance Restores Memory Deficit in Global Ischemia/Reperfusion Model in Rats"

A M Choucry, M Y Al-Shorbagy, A S Attia, et al.

From:Journal of Molecular Neuroscience

References

1.

"The stress-activated protein kinase subfamily of c-Jun kinases."
Kyriakis J.M. , Banerjee P. , Nikolakaki E. , Dai T. , Rubie E.A. , Ahmad M.F. , Avruch J. , Woodgett J.R.
Nature369:156-160(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Brain.
2.

"Stimulation of 'stress-regulated' mitogen-activated protein kinases (stress-activated protein kinases/c-Jun N-terminal kinases and p38-mitogen-activated protein kinases) in perfused rat hearts by oxidative and other stresses."
Clerk A. , Fuller S.J. , Michael A. , Sugden P.H.
J. Biol. Chem.273:7228-7234(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;COFACTOR
tissue: Heart.
3.

"Nitric oxide negatively regulates c-Jun N-terminal kinase/stress-activated protein kinase by means of S-nitrosylation."
Park H.S. , Huh S.H. , Kim M.S. , Lee S.H. , Choi E.J.
Proc. Natl. Acad. Sci. U.S.A.97:14382-14387(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: S-NITROSYLATION AT CYS-116;MUTAGENESIS OF CYS-116
4.

"Cytoplasmic retention sites in p190RhoGEF confer anti-apoptotic activity to an EGFP-tagged protein."
Wu J. , Zhai J. , Lin H. , Nie Z. , Ge W.-W. , Garcia-Bermejo L. , Muschel R.J. , Schlaepfer W.W. , Canete-Soler R.
Brain Res. Mol. Brain Res.117:27-38(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN A COMPLEX WITH MAPK8IP1 AND ARHGEF28
5.

"JNK1 phosphorylation of SCG10 determines microtubule dynamics and axodendritic length."
Tararuk T. , Ostman N. , Li W. , Bjorkblom B. , Padzik A. , Zdrojewska J. , Hongisto V. , Herdegen T. , Konopka W. , Courtney M.J. , Coffey E.T.
J. Cell Biol.173:265-277(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH MAPK8IP1; STMN2; STMN3 AND STMN4;SUBCELLULAR LOCATION
6.

"Phosphorylation of SCG10/stathmin-2 determines multipolar stage exit and neuronal migration rate."
Westerlund N. , Zdrojewska J. , Padzik A. , Komulainen E. , Bjorkblom B. , Rannikko E. , Tararuk T. , Garcia-Frigola C. , Sandholm J. , Nguyen L. , Kallunki T. , Courtney M.J. , Coffey E.T.
Nat. Neurosci.14:305-313(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION

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