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Index > Protein center > NEK1(Gene name) > Human
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  • NEK1 (Gene name),
  • Serine/threonine-protein kinase Nek1 (Protein name ),  NEK1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    NEK1(KIAA1901);
    Protein name:
    Serine/threonine-protein kinase Nek1;
    Alternative:
    Renal carcinoma antigen NY-REN-55;Never in mitosis A-related kinase 1(NimA-related protein kinase 1);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Binds to SPERT.
    Function:
    Phosphorylates serines and threonines, but also appears to possess tyrosine kinase activity. Implicated in the control of meiosis (By similarity). Involved in cilium assembly.
    Subcellular Location:
    Nucleus Cytoplasm cytoskeleton centrosome Associated with the pericentriolar material. Localizes to centrosome during interphase and mitosis.
    Protein Attributes:
    Sequence length:
    1258
    Sequence:
    50:
    MEKYVRLQKI | GEGSFGKAIL | VKSTEDGRQY | VIKEINISRM | SSKEREESRR | 
    100:
    EVAVLANMKH | PNIVQYRESF | EENGSLYIVM | DYCEGGDLFK | RINAQKGVLF | 
    150:
    QEDQILDWFV | QICLALKHVH | DRKILHRDIK | SQNIFLTKDG | TVQLGDFGIA | 
    200:
    RVLNSTVELA | RTCIGTPYYL | SPEICENKPY | NNKSDIWALG | CVLYELCTLK | 
    250:
    HAFEAGSMKN | LVLKIISGSF | PPVSLHYSYD | LRSLVSQLFK | RNPRDRPSVN | 
    300:
    SILEKGFIAK | RIEKFLSPQL | IAEEFCLKTF | SKFGSQPIPA | KRPASGQNSI | 
    350:
    SVMPAQKITK | PAAKYGIPLA | YKKYGDKKLH | EKKPLQKHKQ | AHQTPEKRVN | 
    400:
    TGEERRKISE | EAARKRRLEF | IEKEKKQKDQ | IISLMKAEQM | KRQEKERLER | 
    450:
    INRAREQGWR | NVLSAGGSGE | VKAPFLGSGG | TIAPSSFSSR | GQYEHYHAIF | 
    500:
    DQMQQQRAED | NEAKWKREIY | GRGLPERGIL | PGVRPGFPYG | AAGHHHFPDA | 
    550:
    DDIRKTLKRL | KAVSKQANAN | RQKGQLAVER | AKQVEEFLQR | KREAMQNKAR | 
    600:
    AEGHMVYLAR | LRQIRLQNFN | ERQQIKAKLR | GEKKEANHSE | GQEGSEEADM | 
    650:
    RRKKIESLKA | HANARAAVLK | EQLERKRKEA | YEREKKVWEE | HLVAKGVKSS | 
    700:
    DVSPPLGQHE | TGGSPSKQQM | RSVISVTSAL | KEVGVDSSLT | DTRETSEEMQ | 
    750:
    KTNNAISSKR | EILRRLNENL | KAQEDEKGKQ | NLSDTFEINV | HEDAKEHEKE | 
    800:
    KSVSSDRKKW | EAGGQLVIPL | DELTLDTSFS | TTERHTVGEV | IKLGPNGSPR | 
    850:
    RAWGKSPTDS | VLKILGEAEL | QLQTELLENT | TIRSEISPEG | EKYKPLITGE | 
    900:
    KKVQCISHEI | NPSAIVDSPV | ETKSPEFSEA | SPQMSLKLEG | NLEEPDDLET | 
    950:
    EILQEPSGTN | KDESLPCTIT | DVWISEEKET | KETQSADRIT | IQENEVSEDG | 
    1000:
    VSSTVDQLSD | IHIEPGTNDS | QHSKCDVDKS | VQPEPFFHKV | VHSEHLNLVP | 
    1050:
    QVQSVQCSPE | ESFAFRSHSH | LPPKNKNKNS | LLIGLSTGLF | DANNPKMLRT | 
    1100:
    CSLPDLSKLF | RTLMDVPTVG | DVRQDNLEID | EIEDENIKEG | PSDSEDIVFE | 
    1150:
    ETDTDLQELQ | ASMEQLLREQ | PGEEYSEEEE | SVLKNSDVEP | TANGTDVADE | 
    1200:
    DDNPSSESAL | NEEWHSDNSD | GEIASECECD | SVFNHLEELR | LHLEQEMGFE | 
    1250:
    KFFEVYEKIK | AIHEDEDENI | EICSKIVQNI | LGNEHQHLYA | KILHLVMADG | 
    1258:
    AYQEDNDE
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    MIM:
    UniGene:
    String:
    KEGG:
    Pfam:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Human Serine/threonine-protein kinase Nek1
    ELISA Kit for Human Serine/threonine-protein kinase Nek1
    CLIA Kit for Human Serine/threonine-protein kinase Nek1
    CLIA Kit for Human Serine/threonine-protein kinase Nek1
    Polyclonal Antibody for Human Serine/threonine-protein kinase Nek1
    Polyclonal Antibody for Human Serine/threonine-protein kinase Nek1
    Monoclonal Antibody for Human Serine/threonine-protein kinase Nek1
    Monoclonal Antibody for Human Serine/threonine-protein kinase Nek1
    Protein for Human Serine/threonine-protein kinase Nek1
    Protein for Human Serine/threonine-protein kinase Nek1

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins."
      Nagase T. , Kikuno R. , Ohara O.
      DNA Res.8:179-187(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Brain.
    2. 2.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3);VARIANT GLY-724
      tissue: Uterus.
    3. 3.
      "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W. , Graves T.A. , Fulton R.S. , Fulton L.A. , Pepin K.H. , Minx P. , Wagner-McPherson C. , Layman D. , Wylie K. , Sekhon M. , Becker M.C. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , Nash W.E. , Kremitzki C. , Oddy L. , Du H. , more...
      Nature434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4)
      tissue: Bone marrow.
      tissue: Brain.
    6. 6.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 91-1258 (ISOFORM 5);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 865-1258
    7. 7.
      "Antigens recognized by autologous antibody in patients with renal-cell carcinoma."
      Scanlan M.J. , Gordan J.D. , Williamson B. , Stockert E. , Bander N.H. , Jongeneel C.V. , Gure A.O. , Jaeger D. , Jaeger E. , Knuth A. , Chen Y.-T. , Old L.J.
      Int. J. Cancer83:456-464(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 444-1258 (ISOFORM 2);IDENTIFICATION AS A RENAL CANCER ANTIGEN
      tissue: Renal cell carcinoma.
    8. 8.
      "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H. , Olsen J.V. , Bairlein M. , Gnad F. , Oppermann F.S. , Korner R. , Greff Z. , Keri G. , Stemmann O. , Mann M.
      Mol. Cell31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    9. 9.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    10. 10.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-414; SER-418; SER-428; SER-653; SER-798; SER-834; SER-868 AND SER-881;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    11. 11.
      "Phosphorylation by Nek1 regulates opening and closing of voltage dependent anion channel 1."
      Chen Y. , Gaczynska M. , Osmulski P. , Polci R. , Riley D.J.
      Biochem. Biophys. Res. Commun.394:798-803(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF VDAC1
    12. 12.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY;SUBCELLULAR LOCATION;INVOLVEMENT IN DIGENIC SHORT-RIB THORACIC DYSPLASIA 3/6 WITH POLYDACTYLY
    13. 13.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    14. 14.
      "Patterns of somatic mutation in human cancer genomes."
      Greenman C. , Stephens P. , Smith R. , Dalgliesh G.L. , Hunter C. , Bignell G. , Davies H. , Teague J. , Butler A. , Stevens C. , Edkins S. , O'Meara S. , Vastrik I. , Schmidt E.E. , Avis T. , Barthorpe S. , Bhamra G. , Buck G. , more...
      Nature446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS [LARGE SCALE ANALYSIS] PHE-10; LYS-25; VAL-76; PRO-294; GLY-355; VAL-463; THR-598; GLY-724; ASN-745; GLU-883 AND ASN-1180
    15. 15.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS SRTD6 ARG-145 AND SER-253
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