Gene name:
NEK1 (KIAA1901) ;
Protein name:
Serine/threonine-protein kinase Nek1 ;
Alternative:
Renal carcinoma antigen NY-REN-55 ;Never in mitosis A-related kinase 1 (NimA-related protein kinase 1) ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Binds to SPERT.
Function:
Phosphorylates serines and threonines, but also appears to possess tyrosine kinase activity. Implicated in the control of meiosis (By similarity). Involved in cilium assembly.
Subcellular Location:
Nucleus
Cytoplasm
cytoskeleton
centrosome
Associated with the pericentriolar material. Localizes to centrosome during interphase and mitosis.
Protein Attributes:
50:
MEKYVRLQKI | GEGSFGKAIL | VKSTEDGRQY | VIKEINISRM | SSKEREESRR |
100:
EVAVLANMKH | PNIVQYRESF | EENGSLYIVM | DYCEGGDLFK | RINAQKGVLF |
150:
QEDQILDWFV | QICLALKHVH | DRKILHRDIK | SQNIFLTKDG | TVQLGDFGIA |
200:
RVLNSTVELA | RTCIGTPYYL | SPEICENKPY | NNKSDIWALG | CVLYELCTLK |
250:
HAFEAGSMKN | LVLKIISGSF | PPVSLHYSYD | LRSLVSQLFK | RNPRDRPSVN |
300:
SILEKGFIAK | RIEKFLSPQL | IAEEFCLKTF | SKFGSQPIPA | KRPASGQNSI |
350:
SVMPAQKITK | PAAKYGIPLA | YKKYGDKKLH | EKKPLQKHKQ | AHQTPEKRVN |
400:
TGEERRKISE | EAARKRRLEF | IEKEKKQKDQ | IISLMKAEQM | KRQEKERLER |
450:
INRAREQGWR | NVLSAGGSGE | VKAPFLGSGG | TIAPSSFSSR | GQYEHYHAIF |
500:
DQMQQQRAED | NEAKWKREIY | GRGLPERGIL | PGVRPGFPYG | AAGHHHFPDA |
550:
DDIRKTLKRL | KAVSKQANAN | RQKGQLAVER | AKQVEEFLQR | KREAMQNKAR |
600:
AEGHMVYLAR | LRQIRLQNFN | ERQQIKAKLR | GEKKEANHSE | GQEGSEEADM |
650:
RRKKIESLKA | HANARAAVLK | EQLERKRKEA | YEREKKVWEE | HLVAKGVKSS |
700:
DVSPPLGQHE | TGGSPSKQQM | RSVISVTSAL | KEVGVDSSLT | DTRETSEEMQ |
750:
KTNNAISSKR | EILRRLNENL | KAQEDEKGKQ | NLSDTFEINV | HEDAKEHEKE |
800:
KSVSSDRKKW | EAGGQLVIPL | DELTLDTSFS | TTERHTVGEV | IKLGPNGSPR |
850:
RAWGKSPTDS | VLKILGEAEL | QLQTELLENT | TIRSEISPEG | EKYKPLITGE |
900:
KKVQCISHEI | NPSAIVDSPV | ETKSPEFSEA | SPQMSLKLEG | NLEEPDDLET |
950:
EILQEPSGTN | KDESLPCTIT | DVWISEEKET | KETQSADRIT | IQENEVSEDG |
1000:
VSSTVDQLSD | IHIEPGTNDS | QHSKCDVDKS | VQPEPFFHKV | VHSEHLNLVP |
1050:
QVQSVQCSPE | ESFAFRSHSH | LPPKNKNKNS | LLIGLSTGLF | DANNPKMLRT |
1100:
CSLPDLSKLF | RTLMDVPTVG | DVRQDNLEID | EIEDENIKEG | PSDSEDIVFE |
1150:
ETDTDLQELQ | ASMEQLLREQ | PGEEYSEEEE | SVLKNSDVEP | TANGTDVADE |
1200:
DDNPSSESAL | NEEWHSDNSD | GEIASECECD | SVFNHLEELR | LHLEQEMGFE |
1250:
KFFEVYEKIK | AIHEDEDENI | EICSKIVQNI | LGNEHQHLYA | KILHLVMADG |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Human
ELISA Kit for Human Serine/threonine-protein kinase Nek1
ELISA Kit for Human Serine/threonine-protein kinase Nek1
CLIA Kit for Human Serine/threonine-protein kinase Nek1
CLIA Kit for Human Serine/threonine-protein kinase Nek1
Polyclonal Antibody for Human Serine/threonine-protein kinase Nek1
Polyclonal Antibody for Human Serine/threonine-protein kinase Nek1
Monoclonal Antibody for Human Serine/threonine-protein kinase Nek1
Monoclonal Antibody for Human Serine/threonine-protein kinase Nek1
Protein for Human Serine/threonine-protein kinase Nek1
Protein for Human Serine/threonine-protein kinase Nek1
R&D Technical Data
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Precision
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Recovery
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Linearity
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Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;TISSUE SPECIFICITY;SUBCELLULAR LOCATION;INVOLVEMENT IN DIGENIC SHORT-RIB THORACIC DYSPLASIA 3/6 WITH POLYDACTYLY
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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Cited for : VARIANTS [LARGE SCALE ANALYSIS] PHE-10; LYS-25; VAL-76; PRO-294; GLY-355; VAL-463; THR-598; GLY-724; ASN-745; GLU-883 AND ASN-1180
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"NEK1 and DYNC2H1 are both involved in short rib polydactyly Majewski type but not in Beemer Langer cases."
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Abstract ]
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Cited for : VARIANTS SRTD6 ARG-145 AND SER-253