Gene name:
PCLO (ACZ;KIAA0559) ;
Protein name:
Protein piccolo ;
Alternative:
Aczonin ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts with RABAC1/PRA1, RIMS2 and profilin.
Function:
May act as a scaffolding protein involved in the organization of synaptic active zones and in synaptic vesicle trafficking.
Subcellular Location:
Cell junction
synapse
Concentrated at the presynaptic side of synaptic junctions.
Protein Attributes:
50:
MGNEASLEGE | GLPEGLAAAA | AAGGGASGAG | SPSHTAIPAG | MEADLSQLSE |
100:
EERRQIAAVM | SRAQGLPKGS | VPPAAAESPS | MHRKQELDSS | HPPKQSGRPP |
150:
DPGRPAQPGL | SKSRTTDTFR | SEQKLPGRSP | STISLKESKS | RTDLKEEHKS |
200:
SMMPGFLSEV | NALSAVSSVV | NKFNPFDLIS | DSEASQEETT | KKQKVVQKEQ |
250:
GKPEGIIKPP | LQQQPPKPIP | KQQGPGRDPL | QQDGTPKSIS | SQQPEKIKSQ |
300:
PPGTGKPIQG | PTQTPQTDHA | KLPLQRDASR | PQTKQADIVR | GESVKPSLPS |
350:
PSKPPIQQPT | PGKPPAQQPG | HEKSQPGPAK | PPAQPSGLTK | PLAQQPGTVK |
400:
PPVQPPGTTK | PPAQPLGPAK | PPAQQTGSEK | PSSEQPGPKA | LAQPPGVGKT |
450:
PAQQPGPAKP | PTQQVGTPKP | LAQQPGLQSP | AKAPGPTKTP | VQAKPPSQQP |
500:
GSTKPPPQQP | GPAKPSPQQP | GSTKPPSQQP | GSAKPSAQQP | SPAKPSAQQS |
550:
TKPVSQTGSG | KPLQPPTVSP | SAKQPPSQGL | PKTICPLCNT | TELLLHVPEK |
600:
ANFNTCTECQ | TTVCSLCGFN | PNPHLTEVKE | WLCLNCQMKR | ALGGDLAPVP |
650:
SSPQPKLKTA | PVTTTSAVSK | SSPQPQQTSP | KKDAAPKQDL | SKAPEPKKPP |
700:
PLVKQPTLHG | SPSAKAKQPP | EADSLSKPAP | PKEPSVPSEQ | DKAPVADDKP |
750:
KQPKMVKPTT | DLVSSSSATT | KPDIPSSKVQ | SQAEEKTTPP | LKTDSAKPSQ |
800:
SFPPTGEKVS | PFDSKAIPRP | ASDSKIISHP | GPSSESKGQK | QVDPVQKKEE |
850:
PKKAQTKMSP | KPDAKPMPKG | SPTPPGPRPT | AGQTVPTPQQ | SPKPQEQSRR |
900:
FSLNLGSITD | APKSQPTTPQ | ETVTGKLFGF | GASIFSQASN | LISTAGQPGP |
950:
HSQSGPGAPM | KQAPAPSQPP | TSQGPPKSTG | QAPPAPAKSI | PVKKETKAPA |
1000:
AEKLEPKAEQ | APTVKRTETE | KKPPPIKDSK | SLTAEPQKAV | LPTKLEKSPK |
1050:
PESTCPLCKT | ELNIGSKDPP | NFNTCTECKN | QVCNLCGFNP | TPHLTENCQT |
1100:
QRAISGQLGD | IRKMPPAPSG | PKASPMPVPT | ESSSQKTAVP | PQVKLVKKQE |
1150:
QEVKTEAEKV | ILEKVKETLS | MEKIPPMVTT | DQKQEESKLE | KDKASALQEK |
1200:
KPLPEEKKLI | PEEEKIRSEE | KKPLLEEKKP | TPEDKKLLPE | AKTSAPEEQK |
1250:
HDLLKSQVQI | AEEKLEGRVA | PKTVQEGKQP | QTKMEGLPSG | TPQSLPKEDD |
1300:
KTTKTIKEQP | QPPCTAKPDQ | EKEDDKSDTS | SSQQPKSPQG | LSDTGYSSDG |
1350:
ISSSLGEIPS | LIPTDEKDIL | KGLKKDSFSQ | ESSPSSPSDL | AKLESTVLSI |
1400:
LEAQASTLAD | EKSEKKTQPH | EVSPEQPKDQ | EKTQSLSETL | EITISEEEIK |
1450:
ESQEERKDTF | KKDSQQDIPS | SKDHKEKSEF | VDDITTRREP | YDSVEESSES |
1500:
ENSPVPQRKR | RTSVGSSSSD | EYKQEDSQGS | GEEEDFIRKQ | IIEMSADEDA |
1550:
SGSEDDEFIR | NQLKEISSST | ESQKKEETKG | KGKITAGKHR | RLTRKSSTSI |
1600:
DEDAGRRHSW | HDEDDEAFDE | SPELKYRETK | SQESEELVVT | GGGGLRRFKT |
1650:
IELNSTIADK | YSAESSQKKT | SLYFDEEPEL | EMESLTDSPE | DRSRGEGSSS |
1700:
LHASSFTPGT | SPTSVSSLDE | DSDSSPSHKK | GESKQQRKAR | HRPHGPLLPT |
1750:
IEDSSEEEEL | REEEELLKEQ | EKQREIEQQQ | RKSSSKKSKK | DKDELRAQRR |
1800:
RERPKTPPSN | LSPIEDASPT | EELRQAAEME | ELHRSSCSEY | SPSIESDPEG |
1850:
FEISPEKIIE | VQKVYKLPTA | VSLYSPTDEQ | SIMQKEGSQK | ALKSAEEMYE |
1900:
EMMHKTHKYK | AFPAANERDE | VFEKEPLYGG | MLIEDYIYES | LVEDTYNGSV |
1950:
DGSLLTRQEE | ENGFMQQKGR | EQKIRLSEQI | YEDPMQKITD | LQKEFYELES |
2000:
LHSVVPQEDI | VSSSFIIPES | HEIVDLGTMV | TSTEEERKLL | DADAAYEELM |
2050:
KRQQMQLTPG | SSPTQAPIGE | DMTESTMDFD | RMPDASLTSS | VLSGASLTDS |
2100:
TSSATLSIPD | VKITQHFSTE | EIEDEYVTDY | TREIQEIIAH | ESLILTYSEP |
2150:
SESATSVPPS | DTPSLTSSVS | SVCTTDSSSP | ITTLDSITTV | YTEPVDMITK |
2200:
FEDSEEISSS | TYFPGSIIDY | PEEISVSLDR | TAPPDGRASA | DHIVISLSDM |
2250:
ASSIIESVVP | KPEGPVADTV | STDLLISEKD | PVKKAKKETG | NGIILEVLEA |
2300:
YRDKKELEAE | RTKSSLSETV | FDHPPSSVIA | LPMKEQLSTT | YFTSGETFGQ |
2350:
EKPASQLPSG | SPSVSSLPAK | PRPFFRSSSL | DISAQPPPPP | PPPPPPPPPP |
2400:
PPPPPPPLPP | PTSPKPTILP | KKKLTVASPV | TTATPLFDAV | TTLETTAVLR |
2450:
SNGLPVTRIC | TTAPPPVPPK | PSSIPSGLVF | THRPEPSKPP | IAPKPVIPQL |
2500:
PTTTQKPTDI | HPKPTGLSLT | SSMTLNLVTS | ADYKLPSPTS | PLSPHSNKSS |
2550:
PRFSKSLTET | YVVITLPSEP | GTPTDSSASQ | AITSWPLGSP | SKDLVSVEPV |
2600:
FSVVPPVTAV | EIPISSEQTF | YISGALQTFS | ATPVTAPSSF | QAAPTSVTQF |
2650:
LTTEVSKTEV | SATRSTAPSV | GLSSISITIP | PEPLALDNIH | LEKPQYKEDG |
2700:
KLQLVGDVID | LRTVPKVEVK | TTDKCIDLSA | STMDVKRQIT | ANEVYGKQIS |
2750:
AVQPSIINLS | VTSSIVTPVS | LATETVTFVT | CTASASYTTG | TESLVGAEHA |
2800:
MTTPLQLTTS | KHAEPPYRIP | SDQVFPIARE | EAPINLSLGT | PAHAVTLAIT |
2850:
KPVTVPPVGV | TNGWTDSTVS | QGITDGEVVD | LSTTKSHRTV | VTMDESTSSV |
2900:
MTKIIEDEKP | VDLTAGRRAV | CCDVVYKLPF | GRSCTAQQPA | TTLPEDRFGY |
2950:
RDDHYQYDRS | GPYGYRGIGG | MKPSMSDTNL | AEAGHFFYKS | KNAFDYSEGT |
3000:
DTAVDLTSGR | VTTGEVMDYS | SKTTGPYPET | RQVISGAGIS | TPQYSTARMT |
3050:
PPPGPQYCVG | SVLRSSNGVV | YSSVATPTPS | TFAITTQPGS | IFSTTVRDLS |
3100:
GIHTADAVTS | LPAMHHSQPM | PRSYFITTGA | SETDIAVTGI | DISASLQTIT |
3150:
MESLTAETID | SVPTLTTASE | VFPEVVGDES | ALLIVPEEDK | QQQQLDLERE |
3200:
LLELEKIKQQ | RFAEELEWER | QEIQRFREQE | KIMVQKKLEE | LQSMKQHLLF |
3250:
QQEEERQAQF | MMRQETLAQQ | QLQLEQIQQL | QQQLHQQLEE | QKIRQIYQYN |
3300:
YDPSGTASPQ | TTTEQAILEG | QYAALEGSQF | WATEDATTTA | SAVVAIEIPQ |
3350:
SQGWYTVQSD | GVTQYIAPPG | ILSTVSEIPL | TDVVVKEEKQ | PKKRSSGAKV |
3400:
RGQYDDMGEN | MTDDPRSFKK | IVDSGVQTDD | EDATDRSYVS | RRRRTKKSVD |
3450:
TSVQTDDEDQ | DEWDMPTRSR | RKARVGKYGD | SMTEADKTKP | LSKVSSIAVQ |
3500:
TVAEISVQTE | PVGTIRTPSI | RARVDAKVEI | IKHISAPEKT | YKGGSLGCQT |
3550:
EADSDTQSPQ | YLSATSPPKD | KKRPTPLEIG | YSSHLRADST | VQLAPSPPKS |
3600:
PKVLYSPISP | LSPGKALESA | FVPYEKPLPD | DISPQKVLHP | DMAKVPPASP |
3650:
KTAKMMQRSM | SDPKPLSPTA | DESSRAPFQY | TEGYTTKGSQ | TMTSSGAQKK |
3700:
VKRTLPNPPP | EEISTGTQST | FSTMGTVSRR | RICRTNTMAR | AKILQDIDRE |
3750:
LDLVERESAK | LRKKQAELDE | EEKEIDAKLR | YLEMGINRRK | EALLKEREKR |
3800:
ERAYLQGVAE | DRDYMSDSEV | SSTRPTRIES | QHGIERPRTA | PQTEFSQFIP |
3850:
PQTQTESQLV | PPTSPYTQYQ | YSSPALPTQA | PTSYTQQSHF | EQQTLYHQQV |
3900:
SPYQTQPTFQ | AVATMSFTPQ | VQPTPTPQPS | YQLPSQMMVI | QQKPRQTTLY |
3950:
LEPKITSNYE | VIRNQPLMIA | PVSTDNTFAV | SHLGSKYNSL | DLRIGLEERS |
4000:
SMASSPISSI | SADSFYADID | HHTPRNYVLI | DDIGEITKGT | AALSTAFSLH |
4050:
EKDLSKTDRL | LRTTETRRSQ | EVTDFLAPLQ | SSSRLHSYVK | AEEDPMEDPY |
4100:
ELKLLKHQIK | QEFRRGTESL | DHLAGLSHYY | HADTSYRHFP | KSEKYSISRL |
4150:
TLEKQAAKQL | PAAILYQKQS | KHKKSLIDPK | MSKFSPIQES | RDLEPDYSSY |
4200:
MTSSTSSIGG | ISSRARLLQD | DITFGLRKNI | TDQQKFMGSS | LGTGLGTLGN |
4250:
TIRSALQDEA | DKPYSSGSRS | RPSSRPSSVY | GLDLSIKRDS | SSSSLRLKAQ |
4300:
EAEALDVSFS | HASSSARTKP | TSLPISQSRG | RIPIVAQNSE | EESPLSPVGQ |
4350:
PMGMARAAAG | PLPPISADTR | DQFGSSHSLP | EVQQHMREES | RTRGYDRDIA |
4400:
FIMDDFQHAM | SDSEAYHLRR | EETDWFDKPR | ESRLENGHGL | DRKLPERLVH |
4450:
SRPLSQHQEQ | IIQMNGKTMH | YIFPHARIKI | TRDSKDHTVS | MQVLEWNGIP |
4500:
LTSKTYEEVQ | SIISQQSGEA | EICVRLDLNM | LSDSENSQHL | ELHEPPKAVD |
4550:
KAKSPGVDPK | QLAAELQKVS | LQQSPLVLSS | VVEKGSHVHS | GPTSAGSSSV |
4600:
PSPGQPGSPS | VSKKKHGSSK | LQINYDLGNL | IIHILQARNL | VPRDNNGYSD |
4650:
PFVKVYLLPG | RGAEYKRRTK | HVQKSLNPEW | NQTVIYKSIS | MEQLKKKTLE |
4700:
VTVWDYDRFS | SNDFLGEVLI | DLSSTSHLDN | TPRWYPLKEQ | TESIDHGKSH |
4750:
SSQSSQQSPK | PSVIKSRSHG | IFPDPSKDMQ | VPTIEKSHSS | PGSSKSSSEG |
4800:
HLRSHGPSRS | QSKTSVTQTH | LEDAGAAIAA | AEAAVQQLRI | QPTAHKSGQS |
4850:
NHARKQHRHS | IAGVLPIQRT | QSDNLPPPAN | GNQDQSQLAL | RKVMSDGPVK |
4900:
PEGAKPPNHR | PAESSVSTGS | SGSSFGSGYS | VDSEGSSSTA | GETNLFPIPR |
4950:
IGKMGQNGQE | PVKQPGVGVG | LADTEAKTQV | MGEIKIALKK | EMKTDGEQLI |
5000:
VEILQCRNIT | YKFKSPDHLP | DLYVKIYVMN | ISTQKKVIKK | KTRVCRHDRE |
5050:
PSFNETFRFS | LSPAGHSLQI | LLFSNGGKFM | KKTLIGEACI | WLDKVDLRKR |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Rat
Chicken
ELISA Kit for Human Protein piccolo
ELISA Kit for Human Protein piccolo
ELISA Kit for Human Protein piccolo
ELISA Kit for Human Protein piccolo
CLIA Kit for Human Protein piccolo
CLIA Kit for Human Protein piccolo
CLIA Kit for Human Protein piccolo
CLIA Kit for Human Protein piccolo
Polyclonal Antibody for Human Protein piccolo
Polyclonal Antibody for Human Protein piccolo
Polyclonal Antibody for Human Protein piccolo
Polyclonal Antibody for Human Protein piccolo
Monoclonal Antibody for Human Protein piccolo
Monoclonal Antibody for Human Protein piccolo
Monoclonal Antibody for Human Protein piccolo
Monoclonal Antibody for Human Protein piccolo
Protein for Human Protein piccolo
Protein for Human Protein piccolo
Protein for Human Protein piccolo
Protein for Human Protein piccolo
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
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more...
Nature424:157-164(2003)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
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Delcher A.L.
,
Huson D.H.
,
Kravitz S.A.
,
Mouchard L.
,
Reinert K.
,
Remington K.A.
,
Clark A.G.
,
Waterman M.S.
,
Eichler E.E.
,
Adams M.D.
,
Hunkapiller M.W.
,
Myers E.W.
,
Venter J.C.
more...
Submitted (2004-06) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 21-607 (ISOFORMS 5/6)
tissue :
Placenta .
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 37-795 (ISOFORMS 1/2)
tissue :
Brain .
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3655-5065 (ISOFORM 2)
tissue :
Brain .
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : STRUCTURE BY NMR OF 4390-4480