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Index > Protein center > PCLO(Gene name) > Human
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  • PCLO (Gene name),
  • Protein piccolo (Protein name ),  PCLO_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    PCLO(ACZ;KIAA0559);
    Protein name:
    Protein piccolo;
    Alternative:
    Aczonin;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with RABAC1/PRA1, RIMS2 and profilin.
    Function:
    May act as a scaffolding protein involved in the organization of synaptic active zones and in synaptic vesicle trafficking.
    Subcellular Location:
    Cell junction synapse Concentrated at the presynaptic side of synaptic junctions.
    Protein Attributes:
    Sequence length:
    5065
    Sequence:
    50:
    MGNEASLEGE | GLPEGLAAAA | AAGGGASGAG | SPSHTAIPAG | MEADLSQLSE | 
    100:
    EERRQIAAVM | SRAQGLPKGS | VPPAAAESPS | MHRKQELDSS | HPPKQSGRPP | 
    150:
    DPGRPAQPGL | SKSRTTDTFR | SEQKLPGRSP | STISLKESKS | RTDLKEEHKS | 
    200:
    SMMPGFLSEV | NALSAVSSVV | NKFNPFDLIS | DSEASQEETT | KKQKVVQKEQ | 
    250:
    GKPEGIIKPP | LQQQPPKPIP | KQQGPGRDPL | QQDGTPKSIS | SQQPEKIKSQ | 
    300:
    PPGTGKPIQG | PTQTPQTDHA | KLPLQRDASR | PQTKQADIVR | GESVKPSLPS | 
    350:
    PSKPPIQQPT | PGKPPAQQPG | HEKSQPGPAK | PPAQPSGLTK | PLAQQPGTVK | 
    400:
    PPVQPPGTTK | PPAQPLGPAK | PPAQQTGSEK | PSSEQPGPKA | LAQPPGVGKT | 
    450:
    PAQQPGPAKP | PTQQVGTPKP | LAQQPGLQSP | AKAPGPTKTP | VQAKPPSQQP | 
    500:
    GSTKPPPQQP | GPAKPSPQQP | GSTKPPSQQP | GSAKPSAQQP | SPAKPSAQQS | 
    550:
    TKPVSQTGSG | KPLQPPTVSP | SAKQPPSQGL | PKTICPLCNT | TELLLHVPEK | 
    600:
    ANFNTCTECQ | TTVCSLCGFN | PNPHLTEVKE | WLCLNCQMKR | ALGGDLAPVP | 
    650:
    SSPQPKLKTA | PVTTTSAVSK | SSPQPQQTSP | KKDAAPKQDL | SKAPEPKKPP | 
    700:
    PLVKQPTLHG | SPSAKAKQPP | EADSLSKPAP | PKEPSVPSEQ | DKAPVADDKP | 
    750:
    KQPKMVKPTT | DLVSSSSATT | KPDIPSSKVQ | SQAEEKTTPP | LKTDSAKPSQ | 
    800:
    SFPPTGEKVS | PFDSKAIPRP | ASDSKIISHP | GPSSESKGQK | QVDPVQKKEE | 
    850:
    PKKAQTKMSP | KPDAKPMPKG | SPTPPGPRPT | AGQTVPTPQQ | SPKPQEQSRR | 
    900:
    FSLNLGSITD | APKSQPTTPQ | ETVTGKLFGF | GASIFSQASN | LISTAGQPGP | 
    950:
    HSQSGPGAPM | KQAPAPSQPP | TSQGPPKSTG | QAPPAPAKSI | PVKKETKAPA | 
    1000:
    AEKLEPKAEQ | APTVKRTETE | KKPPPIKDSK | SLTAEPQKAV | LPTKLEKSPK | 
    1050:
    PESTCPLCKT | ELNIGSKDPP | NFNTCTECKN | QVCNLCGFNP | TPHLTENCQT | 
    1100:
    QRAISGQLGD | IRKMPPAPSG | PKASPMPVPT | ESSSQKTAVP | PQVKLVKKQE | 
    1150:
    QEVKTEAEKV | ILEKVKETLS | MEKIPPMVTT | DQKQEESKLE | KDKASALQEK | 
    1200:
    KPLPEEKKLI | PEEEKIRSEE | KKPLLEEKKP | TPEDKKLLPE | AKTSAPEEQK | 
    1250:
    HDLLKSQVQI | AEEKLEGRVA | PKTVQEGKQP | QTKMEGLPSG | TPQSLPKEDD | 
    1300:
    KTTKTIKEQP | QPPCTAKPDQ | EKEDDKSDTS | SSQQPKSPQG | LSDTGYSSDG | 
    1350:
    ISSSLGEIPS | LIPTDEKDIL | KGLKKDSFSQ | ESSPSSPSDL | AKLESTVLSI | 
    1400:
    LEAQASTLAD | EKSEKKTQPH | EVSPEQPKDQ | EKTQSLSETL | EITISEEEIK | 
    1450:
    ESQEERKDTF | KKDSQQDIPS | SKDHKEKSEF | VDDITTRREP | YDSVEESSES | 
    1500:
    ENSPVPQRKR | RTSVGSSSSD | EYKQEDSQGS | GEEEDFIRKQ | IIEMSADEDA | 
    1550:
    SGSEDDEFIR | NQLKEISSST | ESQKKEETKG | KGKITAGKHR | RLTRKSSTSI | 
    1600:
    DEDAGRRHSW | HDEDDEAFDE | SPELKYRETK | SQESEELVVT | GGGGLRRFKT | 
    1650:
    IELNSTIADK | YSAESSQKKT | SLYFDEEPEL | EMESLTDSPE | DRSRGEGSSS | 
    1700:
    LHASSFTPGT | SPTSVSSLDE | DSDSSPSHKK | GESKQQRKAR | HRPHGPLLPT | 
    1750:
    IEDSSEEEEL | REEEELLKEQ | EKQREIEQQQ | RKSSSKKSKK | DKDELRAQRR | 
    1800:
    RERPKTPPSN | LSPIEDASPT | EELRQAAEME | ELHRSSCSEY | SPSIESDPEG | 
    1850:
    FEISPEKIIE | VQKVYKLPTA | VSLYSPTDEQ | SIMQKEGSQK | ALKSAEEMYE | 
    1900:
    EMMHKTHKYK | AFPAANERDE | VFEKEPLYGG | MLIEDYIYES | LVEDTYNGSV | 
    1950:
    DGSLLTRQEE | ENGFMQQKGR | EQKIRLSEQI | YEDPMQKITD | LQKEFYELES | 
    2000:
    LHSVVPQEDI | VSSSFIIPES | HEIVDLGTMV | TSTEEERKLL | DADAAYEELM | 
    2050:
    KRQQMQLTPG | SSPTQAPIGE | DMTESTMDFD | RMPDASLTSS | VLSGASLTDS | 
    2100:
    TSSATLSIPD | VKITQHFSTE | EIEDEYVTDY | TREIQEIIAH | ESLILTYSEP | 
    2150:
    SESATSVPPS | DTPSLTSSVS | SVCTTDSSSP | ITTLDSITTV | YTEPVDMITK | 
    2200:
    FEDSEEISSS | TYFPGSIIDY | PEEISVSLDR | TAPPDGRASA | DHIVISLSDM | 
    2250:
    ASSIIESVVP | KPEGPVADTV | STDLLISEKD | PVKKAKKETG | NGIILEVLEA | 
    2300:
    YRDKKELEAE | RTKSSLSETV | FDHPPSSVIA | LPMKEQLSTT | YFTSGETFGQ | 
    2350:
    EKPASQLPSG | SPSVSSLPAK | PRPFFRSSSL | DISAQPPPPP | PPPPPPPPPP | 
    2400:
    PPPPPPPLPP | PTSPKPTILP | KKKLTVASPV | TTATPLFDAV | TTLETTAVLR | 
    2450:
    SNGLPVTRIC | TTAPPPVPPK | PSSIPSGLVF | THRPEPSKPP | IAPKPVIPQL | 
    2500:
    PTTTQKPTDI | HPKPTGLSLT | SSMTLNLVTS | ADYKLPSPTS | PLSPHSNKSS | 
    2550:
    PRFSKSLTET | YVVITLPSEP | GTPTDSSASQ | AITSWPLGSP | SKDLVSVEPV | 
    2600:
    FSVVPPVTAV | EIPISSEQTF | YISGALQTFS | ATPVTAPSSF | QAAPTSVTQF | 
    2650:
    LTTEVSKTEV | SATRSTAPSV | GLSSISITIP | PEPLALDNIH | LEKPQYKEDG | 
    2700:
    KLQLVGDVID | LRTVPKVEVK | TTDKCIDLSA | STMDVKRQIT | ANEVYGKQIS | 
    2750:
    AVQPSIINLS | VTSSIVTPVS | LATETVTFVT | CTASASYTTG | TESLVGAEHA | 
    2800:
    MTTPLQLTTS | KHAEPPYRIP | SDQVFPIARE | EAPINLSLGT | PAHAVTLAIT | 
    2850:
    KPVTVPPVGV | TNGWTDSTVS | QGITDGEVVD | LSTTKSHRTV | VTMDESTSSV | 
    2900:
    MTKIIEDEKP | VDLTAGRRAV | CCDVVYKLPF | GRSCTAQQPA | TTLPEDRFGY | 
    2950:
    RDDHYQYDRS | GPYGYRGIGG | MKPSMSDTNL | AEAGHFFYKS | KNAFDYSEGT | 
    3000:
    DTAVDLTSGR | VTTGEVMDYS | SKTTGPYPET | RQVISGAGIS | TPQYSTARMT | 
    3050:
    PPPGPQYCVG | SVLRSSNGVV | YSSVATPTPS | TFAITTQPGS | IFSTTVRDLS | 
    3100:
    GIHTADAVTS | LPAMHHSQPM | PRSYFITTGA | SETDIAVTGI | DISASLQTIT | 
    3150:
    MESLTAETID | SVPTLTTASE | VFPEVVGDES | ALLIVPEEDK | QQQQLDLERE | 
    3200:
    LLELEKIKQQ | RFAEELEWER | QEIQRFREQE | KIMVQKKLEE | LQSMKQHLLF | 
    3250:
    QQEEERQAQF | MMRQETLAQQ | QLQLEQIQQL | QQQLHQQLEE | QKIRQIYQYN | 
    3300:
    YDPSGTASPQ | TTTEQAILEG | QYAALEGSQF | WATEDATTTA | SAVVAIEIPQ | 
    3350:
    SQGWYTVQSD | GVTQYIAPPG | ILSTVSEIPL | TDVVVKEEKQ | PKKRSSGAKV | 
    3400:
    RGQYDDMGEN | MTDDPRSFKK | IVDSGVQTDD | EDATDRSYVS | RRRRTKKSVD | 
    3450:
    TSVQTDDEDQ | DEWDMPTRSR | RKARVGKYGD | SMTEADKTKP | LSKVSSIAVQ | 
    3500:
    TVAEISVQTE | PVGTIRTPSI | RARVDAKVEI | IKHISAPEKT | YKGGSLGCQT | 
    3550:
    EADSDTQSPQ | YLSATSPPKD | KKRPTPLEIG | YSSHLRADST | VQLAPSPPKS | 
    3600:
    PKVLYSPISP | LSPGKALESA | FVPYEKPLPD | DISPQKVLHP | DMAKVPPASP | 
    3650:
    KTAKMMQRSM | SDPKPLSPTA | DESSRAPFQY | TEGYTTKGSQ | TMTSSGAQKK | 
    3700:
    VKRTLPNPPP | EEISTGTQST | FSTMGTVSRR | RICRTNTMAR | AKILQDIDRE | 
    3750:
    LDLVERESAK | LRKKQAELDE | EEKEIDAKLR | YLEMGINRRK | EALLKEREKR | 
    3800:
    ERAYLQGVAE | DRDYMSDSEV | SSTRPTRIES | QHGIERPRTA | PQTEFSQFIP | 
    3850:
    PQTQTESQLV | PPTSPYTQYQ | YSSPALPTQA | PTSYTQQSHF | EQQTLYHQQV | 
    3900:
    SPYQTQPTFQ | AVATMSFTPQ | VQPTPTPQPS | YQLPSQMMVI | QQKPRQTTLY | 
    3950:
    LEPKITSNYE | VIRNQPLMIA | PVSTDNTFAV | SHLGSKYNSL | DLRIGLEERS | 
    4000:
    SMASSPISSI | SADSFYADID | HHTPRNYVLI | DDIGEITKGT | AALSTAFSLH | 
    4050:
    EKDLSKTDRL | LRTTETRRSQ | EVTDFLAPLQ | SSSRLHSYVK | AEEDPMEDPY | 
    4100:
    ELKLLKHQIK | QEFRRGTESL | DHLAGLSHYY | HADTSYRHFP | KSEKYSISRL | 
    4150:
    TLEKQAAKQL | PAAILYQKQS | KHKKSLIDPK | MSKFSPIQES | RDLEPDYSSY | 
    4200:
    MTSSTSSIGG | ISSRARLLQD | DITFGLRKNI | TDQQKFMGSS | LGTGLGTLGN | 
    4250:
    TIRSALQDEA | DKPYSSGSRS | RPSSRPSSVY | GLDLSIKRDS | SSSSLRLKAQ | 
    4300:
    EAEALDVSFS | HASSSARTKP | TSLPISQSRG | RIPIVAQNSE | EESPLSPVGQ | 
    4350:
    PMGMARAAAG | PLPPISADTR | DQFGSSHSLP | EVQQHMREES | RTRGYDRDIA | 
    4400:
    FIMDDFQHAM | SDSEAYHLRR | EETDWFDKPR | ESRLENGHGL | DRKLPERLVH | 
    4450:
    SRPLSQHQEQ | IIQMNGKTMH | YIFPHARIKI | TRDSKDHTVS | MQVLEWNGIP | 
    4500:
    LTSKTYEEVQ | SIISQQSGEA | EICVRLDLNM | LSDSENSQHL | ELHEPPKAVD | 
    4550:
    KAKSPGVDPK | QLAAELQKVS | LQQSPLVLSS | VVEKGSHVHS | GPTSAGSSSV | 
    4600:
    PSPGQPGSPS | VSKKKHGSSK | LQINYDLGNL | IIHILQARNL | VPRDNNGYSD | 
    4650:
    PFVKVYLLPG | RGAEYKRRTK | HVQKSLNPEW | NQTVIYKSIS | MEQLKKKTLE | 
    4700:
    VTVWDYDRFS | SNDFLGEVLI | DLSSTSHLDN | TPRWYPLKEQ | TESIDHGKSH | 
    4750:
    SSQSSQQSPK | PSVIKSRSHG | IFPDPSKDMQ | VPTIEKSHSS | PGSSKSSSEG | 
    4800:
    HLRSHGPSRS | QSKTSVTQTH | LEDAGAAIAA | AEAAVQQLRI | QPTAHKSGQS | 
    4850:
    NHARKQHRHS | IAGVLPIQRT | QSDNLPPPAN | GNQDQSQLAL | RKVMSDGPVK | 
    4900:
    PEGAKPPNHR | PAESSVSTGS | SGSSFGSGYS | VDSEGSSSTA | GETNLFPIPR | 
    4950:
    IGKMGQNGQE | PVKQPGVGVG | LADTEAKTQV | MGEIKIALKK | EMKTDGEQLI | 
    5000:
    VEILQCRNIT | YKFKSPDHLP | DLYVKIYVMN | ISTQKKVIKK | KTRVCRHDRE | 
    5050:
    PSFNETFRFS | LSPAGHSLQI | LLFSNGGKFM | KKTLIGEACI | WLDKVDLRKR | 
    5065:
    IVNWHKLLVS | PTQTH
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    MIM:
    UniGene:
    Pfam:
    String:
    KEGG:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Human Protein piccolo
    ELISA Kit for Human Protein piccolo
    ELISA Kit for Human Protein piccolo
    ELISA Kit for Human Protein piccolo
    CLIA Kit for Human Protein piccolo
    CLIA Kit for Human Protein piccolo
    CLIA Kit for Human Protein piccolo
    CLIA Kit for Human Protein piccolo
    Polyclonal Antibody for Human Protein piccolo
    Polyclonal Antibody for Human Protein piccolo
    Polyclonal Antibody for Human Protein piccolo
    Polyclonal Antibody for Human Protein piccolo
    Monoclonal Antibody for Human Protein piccolo
    Monoclonal Antibody for Human Protein piccolo
    Monoclonal Antibody for Human Protein piccolo
    Monoclonal Antibody for Human Protein piccolo
    Protein for Human Protein piccolo
    Protein for Human Protein piccolo
    Protein for Human Protein piccolo
    Protein for Human Protein piccolo

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "The DNA sequence of human chromosome 7."
      Hillier L.W. , Fulton R.S. , Fulton L.A. , Graves T.A. , Pepin K.H. , Wagner-McPherson C. , Layman D. , Maas J. , Jaeger S. , Walker R. , Wylie K. , Sekhon M. , Becker M.C. , O'Laughlin M.D. , Schaller M.E. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , more...
      Nature424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    2. 2.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 21-607 (ISOFORMS 5/6)
      tissue: Placenta.
    4. 4.
      "Aczonin, a 550-kd putative scaffolding protein of presynaptic active zones, shares homology regions with rim and bassoon and binds profilin."
      Wang X. , Kibschull M. , Laue M.M. , Lichte B. , Petrasch-Parwez E. , Kilimann M.W.
      J. Cell Biol.147:151-162(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 37-795 (ISOFORMS 1/2)
      tissue: Brain.
    5. 5.
      "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
      Nagase T. , Ishikawa K. , Miyajima N. , Tanaka A. , Kotani H. , Nomura N. , Ohara O.
      DNA Res.5:31-39(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3655-5065 (ISOFORM 2)
      tissue: Brain.
    6. 6.
      "Solution structure of RSGI RUH-003, a PDZ domain of hypothetical KIAA0559 protein from human."
      RIKEN structural genomics initiative (RSGI)
      Submitted (2004-01) to the PDB data bank
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 4390-4480
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